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The map label for this gene is rnr [H]

Identifier: 32266033

GI number: 32266033

Start: 515008

End: 516852

Strand: Direct

Name: rnr [H]

Synonym: HH0534

Alternate gene names: 32266033

Gene position: 515008-516852 (Clockwise)

Preceding gene: 32266032

Following gene: 32266034

Centisome position: 28.63

GC content: 37.18

Gene sequence:

>1845_bases
GTGCTTGAAAATAAAGGTGAATATTGCATACTTAAGCCTCACTTTATTATAGGCAGTGTAGATATTTCACGCAGTGGAAA
AATCTACATCAAAAGCTTGAATATAAAAGATGAAAATGATTTTCTCCTTGAAAATGGACGATATGTTAAGCTCAAAAAAG
GTGATATTATTCTCGCAAAGCACACAACAAAAAAAGCGCGTTTTATTACATTGCTTTACTCACCAAAAACTTATACCCTT
GCTACTCTTGTGATGAAAAAGGGGGTAATTAAAGCTCTTGAGCTTGATACAAAAAGTGGAAAAGAACATTATATAGAACT
TAAAGTCTCACAAAAATCGCTCAAAGCTTTGCCTCCGCACTGCGTGGTAAAGGTTGAGCTTTTATCTGGCAATATTGTTG
AAGTGCTTGGAGTGCTTGGAGATGCACAAATTGACGAAAAAATAGTCCTAAGCTCTTATAATCGCGTCAATGAATTTAGC
TCTAATGTCAAGGAGTTTGCTCAATCTTTTGGCGATGAAGTATGTAAAGAGATGTATCCCCATCGTGTAGATTTAAGCCA
CTTGCCTTTTTGTGTGATAGACCCCAAAGACGCACGCGACCACGATGATGCGATTTATTTTGAAAGCAAAACAAAAACGC
TTTATGTGGCTATTGCCGATGTAAGCGAATATGTAAGCTGTGAAAGTGTGCTTGATAAGGAAGCAAGACAAAGAGGTTTT
AGCATATATTTTCCGCATAAAGTTGTGCCTATGCTCCCCTTTGAGCTAAGCAGCGGAATCTGCTCGTTAAAAGAAAACAA
AGTGCGTTTAGCAATGGTATGGAAAATAACGCTTGATAAAAACGCACAAGTGCAAAAAAGTGAGCTCTTAGAAGCCTTTA
TACAATCTCACGCAAATGTCAGCTATGAAAACATAGAATCTTTTTTGCAAGGACACAAAAGCACTCTGCCAAAAGAGATT
CAAAAATGGCTTAAGGCATATTTGCCTTATATCAAAAAACACAGGGCTATGCGCTTGCAGTATGGCTATGAATTTCAAAG
CAATGAAATCAAGTTGGAACTTGATGAGTATCAAAATATAAGCTCGTGGCACAAAGTAGAGCACACTTTGGCTCATAGCA
TCATTGAAGAATCTATGCTCCTTGCAAATGTGCAAAGTGCGCTTATGCTCATCAATAATACACAAAAGGGCATTTTTAGA
ATCCACCCTCCCCCCAAAGAAGAGCGCATACAATCACTACTATGGGAAATAAAAAATATGGGCTTTGAGCTACCCTCTAC
ACTTGATTTTCACAGCCTTATATTAGCTATACAAAACCAAGTCAAAGGAAGCAATATGGCAGAAGTGCTTGATGATATGA
TTATCAAATCTTTTGCTAAGGCAACTTATAGTGTCATCAATATCGGGCATTTTGGCTTAGGATTTGAGAGTTATACACAT
TTTACCTCTCCTATTCGCCGATATAGCGACTTAATCGTGCATAGAATCTTAAAAGCACTTCTTCATAAGGATAAATCCCT
GTCTTTCTTACTTGAGGGGCTCAATGGTATTGCTCAAGAGATGAACATCAAACAAAAGCAAGTGAGCCATATTGAGCAGG
ATTTTTATCAACGCAAAATGCTTGCCTTTACACAAAAACTCTTAGAATCTATTCTACCTCTTATCTGCACTGCACTTGTG
GTAGAAGAAGATTCTTATGCTATTGCGCTAGATACTATCCCGCAAATAAAAATTGCTCTTTCACACTCATTTGAGAGATT
TAAACTTGTAAAAGTGCAAATAGAAAAAGTGGATTTGCTTTGTGGCTATGTGCAAGGAAGAGTAATAGAATCTATCAGTC
ATTAA

Upstream 100 bases:

>100_bases
AGCAATGATATATTTTTACGCTCTTATTTCCTCTGGCACGATAAGGAGGCGCATTCCCAAATCTTTTGCTCACGCACTTA
AACATTTAGAAGAGATAAAT

Downstream 100 bases:

>100_bases
GTCTTAAAATTGACTAAAATTAAAATGTTACTTTATGAAAAATATTATTTCAATATTTCAAAATCATTTTTAAGGAATCT
CACAATGAGCAAGATTTTGA

Product: hypothetical protein

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MLENKGEYCILKPHFIIGSVDISRSGKIYIKSLNIKDENDFLLENGRYVKLKKGDIILAKHTTKKARFITLLYSPKTYTL
ATLVMKKGVIKALELDTKSGKEHYIELKVSQKSLKALPPHCVVKVELLSGNIVEVLGVLGDAQIDEKIVLSSYNRVNEFS
SNVKEFAQSFGDEVCKEMYPHRVDLSHLPFCVIDPKDARDHDDAIYFESKTKTLYVAIADVSEYVSCESVLDKEARQRGF
SIYFPHKVVPMLPFELSSGICSLKENKVRLAMVWKITLDKNAQVQKSELLEAFIQSHANVSYENIESFLQGHKSTLPKEI
QKWLKAYLPYIKKHRAMRLQYGYEFQSNEIKLELDEYQNISSWHKVEHTLAHSIIEESMLLANVQSALMLINNTQKGIFR
IHPPPKEERIQSLLWEIKNMGFELPSTLDFHSLILAIQNQVKGSNMAEVLDDMIIKSFAKATYSVINIGHFGLGFESYTH
FTSPIRRYSDLIVHRILKALLHKDKSLSFLLEGLNGIAQEMNIKQKQVSHIEQDFYQRKMLAFTQKLLESILPLICTALV
VEEDSYAIALDTIPQIKIALSHSFERFKLVKVQIEKVDLLCGYVQGRVIESISH

Sequences:

>Translated_614_residues
MLENKGEYCILKPHFIIGSVDISRSGKIYIKSLNIKDENDFLLENGRYVKLKKGDIILAKHTTKKARFITLLYSPKTYTL
ATLVMKKGVIKALELDTKSGKEHYIELKVSQKSLKALPPHCVVKVELLSGNIVEVLGVLGDAQIDEKIVLSSYNRVNEFS
SNVKEFAQSFGDEVCKEMYPHRVDLSHLPFCVIDPKDARDHDDAIYFESKTKTLYVAIADVSEYVSCESVLDKEARQRGF
SIYFPHKVVPMLPFELSSGICSLKENKVRLAMVWKITLDKNAQVQKSELLEAFIQSHANVSYENIESFLQGHKSTLPKEI
QKWLKAYLPYIKKHRAMRLQYGYEFQSNEIKLELDEYQNISSWHKVEHTLAHSIIEESMLLANVQSALMLINNTQKGIFR
IHPPPKEERIQSLLWEIKNMGFELPSTLDFHSLILAIQNQVKGSNMAEVLDDMIIKSFAKATYSVINIGHFGLGFESYTH
FTSPIRRYSDLIVHRILKALLHKDKSLSFLLEGLNGIAQEMNIKQKQVSHIEQDFYQRKMLAFTQKLLESILPLICTALV
VEEDSYAIALDTIPQIKIALSHSFERFKLVKVQIEKVDLLCGYVQGRVIESISH
>Mature_614_residues
MLENKGEYCILKPHFIIGSVDISRSGKIYIKSLNIKDENDFLLENGRYVKLKKGDIILAKHTTKKARFITLLYSPKTYTL
ATLVMKKGVIKALELDTKSGKEHYIELKVSQKSLKALPPHCVVKVELLSGNIVEVLGVLGDAQIDEKIVLSSYNRVNEFS
SNVKEFAQSFGDEVCKEMYPHRVDLSHLPFCVIDPKDARDHDDAIYFESKTKTLYVAIADVSEYVSCESVLDKEARQRGF
SIYFPHKVVPMLPFELSSGICSLKENKVRLAMVWKITLDKNAQVQKSELLEAFIQSHANVSYENIESFLQGHKSTLPKEI
QKWLKAYLPYIKKHRAMRLQYGYEFQSNEIKLELDEYQNISSWHKVEHTLAHSIIEESMLLANVQSALMLINNTQKGIFR
IHPPPKEERIQSLLWEIKNMGFELPSTLDFHSLILAIQNQVKGSNMAEVLDDMIIKSFAKATYSVINIGHFGLGFESYTH
FTSPIRRYSDLIVHRILKALLHKDKSLSFLLEGLNGIAQEMNIKQKQVSHIEQDFYQRKMLAFTQKLLESILPLICTALV
VEEDSYAIALDTIPQIKIALSHSFERFKLVKVQIEKVDLLCGYVQGRVIESISH

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=436, Percent_Identity=27.0642201834862, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI190014625, Length=436, Percent_Identity=27.0642201834862, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI134288890, Length=440, Percent_Identity=27.7272727272727, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI219521928, Length=466, Percent_Identity=28.755364806867, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI19115966, Length=466, Percent_Identity=28.755364806867, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI87082383, Length=526, Percent_Identity=31.7490494296578, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI1787542, Length=345, Percent_Identity=30.4347826086957, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI212645896, Length=441, Percent_Identity=28.1179138321995, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17553506, Length=471, Percent_Identity=26.963906581741, Blast_Score=130, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324552, Length=425, Percent_Identity=28.4705882352941, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320499, Length=400, Percent_Identity=23.75, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323943, Length=362, Percent_Identity=23.7569060773481, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649634, Length=403, Percent_Identity=29.7766749379653, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922976, Length=428, Percent_Identity=28.2710280373832, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24654597, Length=428, Percent_Identity=28.2710280373832, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24654592, Length=428, Percent_Identity=28.2710280373832, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 70272; Mature: 70272

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENKGEYCILKPHFIIGSVDISRSGKIYIKSLNIKDENDFLLENGRYVKLKKGDIILAK
CCCCCCCEEEEECCEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCEEEEECCCEEEEE
HTTKKARFITLLYSPKTYTLATLVMKKGVIKALELDTKSGKEHYIELKVSQKSLKALPPH
CCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECHHHHHCCCCC
CVVKVELLSGNIVEVLGVLGDAQIDEKIVLSSYNRVNEFSSNVKEFAQSFGDEVCKEMYP
EEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HRVDLSHLPFCVIDPKDARDHDDAIYFESKTKTLYVAIADVSEYVSCESVLDKEARQRGF
CCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCC
SIYFPHKVVPMLPFELSSGICSLKENKVRLAMVWKITLDKNAQVQKSELLEAFIQSHANV
EEECCCCCCCCCCHHHCCCCEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
SYENIESFLQGHKSTLPKEIQKWLKAYLPYIKKHRAMRLQYGYEFQSNEIKLELDEYQNI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEECCCCEEEEEHHHCCH
SSWHKVEHTLAHSIIEESMLLANVQSALMLINNTQKGIFRIHPPPKEERIQSLLWEIKNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCHHHHHHHHHHHHHHC
GFELPSTLDFHSLILAIQNQVKGSNMAEVLDDMIIKSFAKATYSVINIGHFGLGFESYTH
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHH
FTSPIRRYSDLIVHRILKALLHKDKSLSFLLEGLNGIAQEMNIKQKQVSHIEQDFYQRKM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAFTQKLLESILPLICTALVVEEDSYAIALDTIPQIKIALSHSFERFKLVKVQIEKVDLL
HHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEECCCCCCEEEEEEEEHHHHHH
CGYVQGRVIESISH
HHHHHHHHHHHHCC
>Mature Secondary Structure
MLENKGEYCILKPHFIIGSVDISRSGKIYIKSLNIKDENDFLLENGRYVKLKKGDIILAK
CCCCCCCEEEEECCEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCEEEEECCCEEEEE
HTTKKARFITLLYSPKTYTLATLVMKKGVIKALELDTKSGKEHYIELKVSQKSLKALPPH
CCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECHHHHHCCCCC
CVVKVELLSGNIVEVLGVLGDAQIDEKIVLSSYNRVNEFSSNVKEFAQSFGDEVCKEMYP
EEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HRVDLSHLPFCVIDPKDARDHDDAIYFESKTKTLYVAIADVSEYVSCESVLDKEARQRGF
CCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCC
SIYFPHKVVPMLPFELSSGICSLKENKVRLAMVWKITLDKNAQVQKSELLEAFIQSHANV
EEECCCCCCCCCCHHHCCCCEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
SYENIESFLQGHKSTLPKEIQKWLKAYLPYIKKHRAMRLQYGYEFQSNEIKLELDEYQNI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEECCCCEEEEEHHHCCH
SSWHKVEHTLAHSIIEESMLLANVQSALMLINNTQKGIFRIHPPPKEERIQSLLWEIKNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCHHHHHHHHHHHHHHC
GFELPSTLDFHSLILAIQNQVKGSNMAEVLDDMIIKSFAKATYSVINIGHFGLGFESYTH
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHH
FTSPIRRYSDLIVHRILKALLHKDKSLSFLLEGLNGIAQEMNIKQKQVSHIEQDFYQRKM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAFTQKLLESILPLICTALVVEEDSYAIALDTIPQIKIALSHSFERFKLVKVQIEKVDLL
HHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEECCCCCCEEEEEEEEHHHHHH
CGYVQGRVIESISH
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]