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The map label for this gene is thrC

Identifier: 32266026

GI number: 32266026

Start: 507717

End: 509261

Strand: Direct

Name: thrC

Synonym: HH0527

Alternate gene names: 32266026

Gene position: 507717-509261 (Clockwise)

Preceding gene: 32266025

Following gene: 32266027

Centisome position: 28.22

GC content: 37.67

Gene sequence:

>1545_bases
ATGAATACATATGATGAGAATCTCTTATATTCCACGCGAGATGATACAGCCTTTGGCGTAAGCTTTCAACACGCTTTATT
ACACCCGAATGCACAACATAATGGGCTTTATACCTTTACCAAACTCCCTCATATCAGCCTAGAGGACATTGAAAATTTTA
CAAACCTTACTTATACCAAGCTGTGCGTAGATATTTTTAATCGCTTAAAACTTGGAATCCATAGAAGTGTGCTTGAAGAA
GCACTTTTAAGCTATAAAAATTTTGATGATTCTTATAATCCTGCTCCACTTAAAGTGGTAAATGAGAATCTCTTTATGCT
TAATCTCTTCTCTGGTCCTACGCGTGCTTTTAAAGATATGGCACTTCAACCCTTTGGACGTTTGTTTGCACATCTTGCTA
CGCAAGATACAAGACCCTATCTTATTCTCACTGCCACAAGCGGTGATACCGGACCTGCAACCTTGCAGAGCTTTGCAAAT
CAACCTCATATCAGGGTTGTGTGCATTTATCCTTATGGAGGCACTAGCGATGTGCAGCGATTACAAATGACAACTCATAC
CGCACCAAATGTAAAAGTTATTGGTATTGAGGGGGATTTTGATGGAGCGCAAAGTGCATTAAAAAAACTTATCGCAAATG
TAGATTTTGTAAAAAAACTCAAAGAGCAAGGATTTGCGCTCTCTGCTGCAAATTCTGTGAATATTGGACGCATTGCATTT
CAAATCATTTATTATTTTTGGGCGTATGTAAAATTACTTAAAGATGGACATATTACACTTGGGGAAAAGATCTCTGTTGT
CGTGCCAAGTGGCAACTTTGGCAATATTTTAGGAGCGTTTTTTGCAAAAAAAATGGGTTTACCCCTTGAGCGTCTTGTGA
GCGCTTCTAATGCAAATAATATCTTAAGTGATTTTATAAACACGGGTGTATATGATATTTCTAAGCGAAACTTAATTAAA
ACCAAATCCCCTGCTATGGATATTTTAAAAAGTTCAAATGTAGAGAGAGTGCTTTATGCACTCTTTGGCGCACAACGCAC
AAAGCAATTAATGGATAGCCTTGATAAAAAAGATTTTTATAGCCTCACTGCTGAAGAGTTAAGCTTACTTCAGCAAGATT
TTAGTGCATTTGAATGTGATGATAAAATGTGTATGCAGAGCATTGCGCAAGGATTCAAAGAAGGATTACTACTTGACCCG
CATAGTGCGATTGCTTATTTTGTAGCAAAAAATTTGCAAAAAAGTAGTGTAATTGGCAAAAGTGTATTTCTTGCCACAGC
AGAATGGAGTAAATTCGCCCCAAGTGTGAGAGAAGCACTCAAAGAAGCAGACATCATTAAAAACACACAAGAAGCTTATG
AAATAAGCGATAAACAAGCCATTGATGAGATTTGCTCACTCTCTTGTGCCAATAATCCTATCAAAGCACCCGAGCAGATT
CTCCAACTTTTTAGCAAAAAAGAAGTGCAGCAAGACATTATCCCTATTCCACAGCTAGAGATGTGTATAATGCGATGGGT
GAGATGTTCTCTCAAGCATTCTTAA

Upstream 100 bases:

>100_bases
GCTTTCTATCAAAGAAGCGGGGAAGCAATCTTAAACTTTATTACCCTAAAAAAATCAAAATATGCTACAATGTGTCCATT
TTAAGGCATAAGGAACATAA

Downstream 100 bases:

>100_bases
AATTAATACAAAATATGGTAAAATGCGCTATAAATCGCTTTTAAATGTGTATAAAATGCTAAATGAAAAGATATAGGAGC
AAAAATGGATTTTGTAAGCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MNTYDENLLYSTRDDTAFGVSFQHALLHPNAQHNGLYTFTKLPHISLEDIENFTNLTYTKLCVDIFNRLKLGIHRSVLEE
ALLSYKNFDDSYNPAPLKVVNENLFMLNLFSGPTRAFKDMALQPFGRLFAHLATQDTRPYLILTATSGDTGPATLQSFAN
QPHIRVVCIYPYGGTSDVQRLQMTTHTAPNVKVIGIEGDFDGAQSALKKLIANVDFVKKLKEQGFALSAANSVNIGRIAF
QIIYYFWAYVKLLKDGHITLGEKISVVVPSGNFGNILGAFFAKKMGLPLERLVSASNANNILSDFINTGVYDISKRNLIK
TKSPAMDILKSSNVERVLYALFGAQRTKQLMDSLDKKDFYSLTAEELSLLQQDFSAFECDDKMCMQSIAQGFKEGLLLDP
HSAIAYFVAKNLQKSSVIGKSVFLATAEWSKFAPSVREALKEADIIKNTQEAYEISDKQAIDEICSLSCANNPIKAPEQI
LQLFSKKEVQQDIIPIPQLEMCIMRWVRCSLKHS

Sequences:

>Translated_514_residues
MNTYDENLLYSTRDDTAFGVSFQHALLHPNAQHNGLYTFTKLPHISLEDIENFTNLTYTKLCVDIFNRLKLGIHRSVLEE
ALLSYKNFDDSYNPAPLKVVNENLFMLNLFSGPTRAFKDMALQPFGRLFAHLATQDTRPYLILTATSGDTGPATLQSFAN
QPHIRVVCIYPYGGTSDVQRLQMTTHTAPNVKVIGIEGDFDGAQSALKKLIANVDFVKKLKEQGFALSAANSVNIGRIAF
QIIYYFWAYVKLLKDGHITLGEKISVVVPSGNFGNILGAFFAKKMGLPLERLVSASNANNILSDFINTGVYDISKRNLIK
TKSPAMDILKSSNVERVLYALFGAQRTKQLMDSLDKKDFYSLTAEELSLLQQDFSAFECDDKMCMQSIAQGFKEGLLLDP
HSAIAYFVAKNLQKSSVIGKSVFLATAEWSKFAPSVREALKEADIIKNTQEAYEISDKQAIDEICSLSCANNPIKAPEQI
LQLFSKKEVQQDIIPIPQLEMCIMRWVRCSLKHS
>Mature_514_residues
MNTYDENLLYSTRDDTAFGVSFQHALLHPNAQHNGLYTFTKLPHISLEDIENFTNLTYTKLCVDIFNRLKLGIHRSVLEE
ALLSYKNFDDSYNPAPLKVVNENLFMLNLFSGPTRAFKDMALQPFGRLFAHLATQDTRPYLILTATSGDTGPATLQSFAN
QPHIRVVCIYPYGGTSDVQRLQMTTHTAPNVKVIGIEGDFDGAQSALKKLIANVDFVKKLKEQGFALSAANSVNIGRIAF
QIIYYFWAYVKLLKDGHITLGEKISVVVPSGNFGNILGAFFAKKMGLPLERLVSASNANNILSDFINTGVYDISKRNLIK
TKSPAMDILKSSNVERVLYALFGAQRTKQLMDSLDKKDFYSLTAEELSLLQQDFSAFECDDKMCMQSIAQGFKEGLLLDP
HSAIAYFVAKNLQKSSVIGKSVFLATAEWSKFAPSVREALKEADIIKNTQEAYEISDKQAIDEICSLSCANNPIKAPEQI
LQLFSKKEVQQDIIPIPQLEMCIMRWVRCSLKHS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=441, Percent_Identity=36.9614512471655, Blast_Score=273, Evalue=4e-73,
Organism=Homo sapiens, GI149193323, Length=443, Percent_Identity=28.2167042889391, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1786185, Length=450, Percent_Identity=29.5555555555556, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319901, Length=471, Percent_Identity=32.6963906581741, Blast_Score=204, Evalue=2e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 57497; Mature: 57497

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYDENLLYSTRDDTAFGVSFQHALLHPNAQHNGLYTFTKLPHISLEDIENFTNLTYTK
CCCCCCCCEEECCCCCEECCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LCVDIFNRLKLGIHRSVLEEALLSYKNFDDSYNPAPLKVVNENLFMLNLFSGPTRAFKDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHH
ALQPFGRLFAHLATQDTRPYLILTATSGDTGPATLQSFANQPHIRVVCIYPYGGTSDVQR
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LQMTTHTAPNVKVIGIEGDFDGAQSALKKLIANVDFVKKLKEQGFALSAANSVNIGRIAF
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCCCHHHHHH
QIIYYFWAYVKLLKDGHITLGEKISVVVPSGNFGNILGAFFAKKMGLPLERLVSASNANN
HHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHH
ILSDFINTGVYDISKRNLIKTKSPAMDILKSSNVERVLYALFGAQRTKQLMDSLDKKDFY
HHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLTAEELSLLQQDFSAFECDDKMCMQSIAQGFKEGLLLDPHSAIAYFVAKNLQKSSVIGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCH
SVFLATAEWSKFAPSVREALKEADIIKNTQEAYEISDKQAIDEICSLSCANNPIKAPEQI
HHEEEECCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LQLFSKKEVQQDIIPIPQLEMCIMRWVRCSLKHS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTYDENLLYSTRDDTAFGVSFQHALLHPNAQHNGLYTFTKLPHISLEDIENFTNLTYTK
CCCCCCCCEEECCCCCEECCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LCVDIFNRLKLGIHRSVLEEALLSYKNFDDSYNPAPLKVVNENLFMLNLFSGPTRAFKDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHH
ALQPFGRLFAHLATQDTRPYLILTATSGDTGPATLQSFANQPHIRVVCIYPYGGTSDVQR
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LQMTTHTAPNVKVIGIEGDFDGAQSALKKLIANVDFVKKLKEQGFALSAANSVNIGRIAF
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCCCHHHHHH
QIIYYFWAYVKLLKDGHITLGEKISVVVPSGNFGNILGAFFAKKMGLPLERLVSASNANN
HHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHH
ILSDFINTGVYDISKRNLIKTKSPAMDILKSSNVERVLYALFGAQRTKQLMDSLDKKDFY
HHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLTAEELSLLQQDFSAFECDDKMCMQSIAQGFKEGLLLDPHSAIAYFVAKNLQKSSVIGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCH
SVFLATAEWSKFAPSVREALKEADIIKNTQEAYEISDKQAIDEICSLSCANNPIKAPEQI
HHEEEECCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LQLFSKKEVQQDIIPIPQLEMCIMRWVRCSLKHS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]