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The map label for this gene is purE

Identifier: 32266027

GI number: 32266027

Start: 509346

End: 509840

Strand: Direct

Name: purE

Synonym: HH0528

Alternate gene names: 32266027

Gene position: 509346-509840 (Clockwise)

Preceding gene: 32266026

Following gene: 32266028

Centisome position: 28.31

GC content: 41.82

Gene sequence:

>495_bases
ATGGATTTTGTAAGCGTCATTATGGGAAGTAAAAGTGATTGGAATGTGATGAGCGAGTGCATAGAAGTGTTAAAGAAATT
TGATGTAGCCTATGAGGTAATAATCAGTTCGGCTCATCGCTCACCAGAGCGCACAAAATCATACATTAAAGATGCACAAT
CTCGTGGTGCGCAGGTTTTCATTGGAGCAGCAGGTATGGCAGCACACTTAGCCGGGGCTATCGCCTCTCAAACTTGTAAG
CCCGTTATTGGTGTGCCACTTAATGGAGGTGCATTAGATGGACTTGATGCTCTTCTCTCAACAGTGCAAATGCCAAGCTC
AATGCCTGTGGCAACGACAAGTATTGGTAAAGCCGGGGCGATTAATGCAGCATATTTAGCAATGCAAATTTTAAGCCTTA
AAAATGATGAACTTGCGGGCAAATTAATAGAAGATAGAGTGATGAAAGCAAAAAAGGTAGAACTAGATTCAGCAGAGATT
GAAGTGAGAATTTAA

Upstream 100 bases:

>100_bases
TCTCAAGCATTCTTAAAATTAATACAAAATATGGTAAAATGCGCTATAAATCGCTTTTAAATGTGTATAAAATGCTAAAT
GAAAAGATATAGGAGCAAAA

Downstream 100 bases:

>100_bases
GGGGACACAATGGAAAATACAACTTGGCTTGTGCTTGAGGAATTTACCAAACTCTCTGGCTTAGATGAAACCAAAATTAT
GGAACTCATTAAAGAAGGAG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MDFVSVIMGSKSDWNVMSECIEVLKKFDVAYEVIISSAHRSPERTKSYIKDAQSRGAQVFIGAAGMAAHLAGAIASQTCK
PVIGVPLNGGALDGLDALLSTVQMPSSMPVATTSIGKAGAINAAYLAMQILSLKNDELAGKLIEDRVMKAKKVELDSAEI
EVRI

Sequences:

>Translated_164_residues
MDFVSVIMGSKSDWNVMSECIEVLKKFDVAYEVIISSAHRSPERTKSYIKDAQSRGAQVFIGAAGMAAHLAGAIASQTCK
PVIGVPLNGGALDGLDALLSTVQMPSSMPVATTSIGKAGAINAAYLAMQILSLKNDELAGKLIEDRVMKAKKVELDSAEI
EVRI
>Mature_164_residues
MDFVSVIMGSKSDWNVMSECIEVLKKFDVAYEVIISSAHRSPERTKSYIKDAQSRGAQVFIGAAGMAAHLAGAIASQTCK
PVIGVPLNGGALDGLDALLSTVQMPSSMPVATTSIGKAGAINAAYLAMQILSLKNDELAGKLIEDRVMKAKKVELDSAEI
EVRI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=109, Percent_Identity=46.7889908256881, Blast_Score=108, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=45.9119496855346, Blast_Score=126, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17355; Mature: 17355

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFVSVIMGSKSDWNVMSECIEVLKKFDVAYEVIISSAHRSPERTKSYIKDAQSRGAQVF
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEE
IGAAGMAAHLAGAIASQTCKPVIGVPLNGGALDGLDALLSTVQMPSSMPVATTSIGKAGA
EECCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCC
INAAYLAMQILSLKNDELAGKLIEDRVMKAKKVELDSAEIEVRI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MDFVSVIMGSKSDWNVMSECIEVLKKFDVAYEVIISSAHRSPERTKSYIKDAQSRGAQVF
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEE
IGAAGMAAHLAGAIASQTCKPVIGVPLNGGALDGLDALLSTVQMPSSMPVATTSIGKAGA
EECCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCC
INAAYLAMQILSLKNDELAGKLIEDRVMKAKKVELDSAEIEVRI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]