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The map label for this gene is dapB

Identifier: 32265986

GI number: 32265986

Start: 472213

End: 472980

Strand: Direct

Name: dapB

Synonym: HH0487

Alternate gene names: 32265986

Gene position: 472213-472980 (Clockwise)

Preceding gene: 32265985

Following gene: 32265987

Centisome position: 26.25

GC content: 39.19

Gene sequence:

>768_bases
ATGCTAAAAGTAGGGATTTTTGGCGCTACGGGACGCGTAGGAAAGCTACTTATTGAAGAAATACTTAATCACACTCACTT
CAATCTCTCAAGTGTATATGTGCGCAATGAATTACAATATTCGCTTCCCTCAAGCACAATGGTAACAAAAGACTTTGAAA
TATTTTTACAAGCAAGCGATGTGATTATTGATTTCTCTTCACCCGAAGCGACAAAAGCACTTCTTGAAGTCGCTCTCTCT
TATCCAAAACCGCTTGTTATAGGCACAACAGGTTTAGATAATGACATACAACATCTCCTTGAAAATGCCTCACATACAAT
GCCTATACTCTATGCAACAAATATGAGTAAAGGGGTAGCAATGCTCAATAAAATTGGCGCATTAGTGGCTGCAACATTAA
AAGAAAGTGATATAGAAATCTGCGAGATTCATCATCGCTACAAAAAAGATGCGCCTTCTGGGACTGCCCTTACTCTTGCT
CAAAGCTGTGCGAAAGCAAGGAATCTCAAATTGAGCGATGTGCGCATAAGCGGACGCAATGGAAATATTGGTGAAAGAAA
TTCTAACGAAATTGGCGTAATGAGCCTACGCGGAGGTGATGTTGCTGGAAGACATACAATTGGATTCTATCTTGATGGTG
AATATTTAGAGCTTACTCATAATGCTACTTCTCGCCTTACTTTTGCTAAGGGTGCACTTGATATGGCAAAATGGATTGTA
ACACAAAAAAATGGGCTTTATAGTATTGAGGATGCACTTGAGATTTAA

Upstream 100 bases:

>100_bases
AGCTGGAGATGGTGCAACTGCGGCATTACAAGCTATTGCATATTTAGAACATAAGTAATATTATATATTTTATAGAATCT
ATTACATTTAAGGAGAATAT

Downstream 100 bases:

>100_bases
GCTTTAAATTTGCTTGTTGGTTTTGTTACTATACAATCGCAGATACAAAACATAATGAGGATAAGGAATGGAAAGCTGGA
ACGAAGAGTGCGCCATTGTG

Product: dihydrodipicolinate reductase

Products: NA

Alternate protein names: DHPR

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLKVGIFGATGRVGKLLIEEILNHTHFNLSSVYVRNELQYSLPSSTMVTKDFEIFLQASDVIIDFSSPEATKALLEVALS
YPKPLVIGTTGLDNDIQHLLENASHTMPILYATNMSKGVAMLNKIGALVAATLKESDIEICEIHHRYKKDAPSGTALTLA
QSCAKARNLKLSDVRISGRNGNIGERNSNEIGVMSLRGGDVAGRHTIGFYLDGEYLELTHNATSRLTFAKGALDMAKWIV
TQKNGLYSIEDALEI

Sequences:

>Translated_255_residues
MLKVGIFGATGRVGKLLIEEILNHTHFNLSSVYVRNELQYSLPSSTMVTKDFEIFLQASDVIIDFSSPEATKALLEVALS
YPKPLVIGTTGLDNDIQHLLENASHTMPILYATNMSKGVAMLNKIGALVAATLKESDIEICEIHHRYKKDAPSGTALTLA
QSCAKARNLKLSDVRISGRNGNIGERNSNEIGVMSLRGGDVAGRHTIGFYLDGEYLELTHNATSRLTFAKGALDMAKWIV
TQKNGLYSIEDALEI
>Mature_255_residues
MLKVGIFGATGRVGKLLIEEILNHTHFNLSSVYVRNELQYSLPSSTMVTKDFEIFLQASDVIIDFSSPEATKALLEVALS
YPKPLVIGTTGLDNDIQHLLENASHTMPILYATNMSKGVAMLNKIGALVAATLKESDIEICEIHHRYKKDAPSGTALTLA
QSCAKARNLKLSDVRISGRNGNIGERNSNEIGVMSLRGGDVAGRHTIGFYLDGEYLELTHNATSRLTFAKGALDMAKWIV
TQKNGLYSIEDALEI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; second step. [C]

COG id: COG0289

COG function: function code E; Dihydrodipicolinate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydrodipicolinate reductase family

Homologues:

Organism=Escherichia coli, GI1786214, Length=265, Percent_Identity=36.2264150943396, Blast_Score=157, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPB_HELHP (Q7VIW7)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860018.1
- ProteinModelPortal:   Q7VIW7
- SMR:   Q7VIW7
- GeneID:   1493541
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0487
- NMPDR:   fig|235279.1.peg.487
- HOGENOM:   HBG594002
- OMA:   GRMGKTL
- ProtClustDB:   PRK00048
- BioCyc:   HHEP235279:HH_0487-MONOMER
- BRENDA:   1.3.1.26
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00102
- InterPro:   IPR022663
- InterPro:   IPR000846
- InterPro:   IPR022664
- InterPro:   IPR011770
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR20836
- TIGRFAMs:   TIGR00036

Pfam domain/function: PF05173 DapB_C; PF01113 DapB_N

EC number: =1.3.1.26

Molecular weight: Translated: 27838; Mature: 27838

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01298 DAPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVGIFGATGRVGKLLIEEILNHTHFNLSSVYVRNELQYSLPSSTMVTKDFEIFLQASD
CEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCEEEECCEEEEEEECE
VIIDFSSPEATKALLEVALSYPKPLVIGTTGLDNDIQHLLENASHTMPILYATNMSKGVA
EEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCHHHH
MLNKIGALVAATLKESDIEICEIHHRYKKDAPSGTALTLAQSCAKARNLKLSDVRISGRN
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCC
GNIGERNSNEIGVMSLRGGDVAGRHTIGFYLDGEYLELTHNATSRLTFAKGALDMAKWIV
CCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHH
TQKNGLYSIEDALEI
CCCCCCEEHHHHHCC
>Mature Secondary Structure
MLKVGIFGATGRVGKLLIEEILNHTHFNLSSVYVRNELQYSLPSSTMVTKDFEIFLQASD
CEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCEEEECCEEEEEEECE
VIIDFSSPEATKALLEVALSYPKPLVIGTTGLDNDIQHLLENASHTMPILYATNMSKGVA
EEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCHHHH
MLNKIGALVAATLKESDIEICEIHHRYKKDAPSGTALTLAQSCAKARNLKLSDVRISGRN
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCC
GNIGERNSNEIGVMSLRGGDVAGRHTIGFYLDGEYLELTHNATSRLTFAKGALDMAKWIV
CCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHH
TQKNGLYSIEDALEI
CCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954