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The map label for this gene is cirA [H]

Identifier: 32265917

GI number: 32265917

Start: 402505

End: 404679

Strand: Direct

Name: cirA [H]

Synonym: HH0418

Alternate gene names: 32265917

Gene position: 402505-404679 (Clockwise)

Preceding gene: 32265912

Following gene: 32265918

Centisome position: 22.37

GC content: 35.26

Gene sequence:

>2175_bases
ATGATGTTTAAAACACTTTGTAATCTGACACTCTGTGTGAGCTTTGGATATTCTATGCAATCCTATACTCTCAATAAATC
AATTATCACAGGTAATGCACTTGCTACTGATGTAGAAAAGATTCCGGGTAATGTAAGTGTGATAGATAACAAACAAATTC
AACATATGCCAAATGCTAAAATAACCGATACAATTAAAAAAATAGCTGGTGTGCGCGTAGATAATGATGTAGGATTTAAT
CCACGTCCAAAAATTAAGATTCGCGGCATCAATTATGGAACACTCCTTATGCTTGATGGCGTGATTCTAAGCGATTTAGA
AGGTGAAAATAGAATCTTAAATCAAATTTCACTTTATGATGTAGAACGCGTAGAGGTAGCTCGTGGAGCATTCTCTAGCC
TCTATGGTGCAGGTGCGATTGGTGGTGTAGTCAATTTTATTACTTCTATGCCTACACAATTTCAATCTCAATTTCTTATA
AGCTATGGAAATGAGTTTATAAATAACACTGCCGATAAGAATCTAATTCGCGCATTTGCAAGTGTAGGCGATGTATTTAT
AGATAAAAGATTAAGACTAAAGCTAAGTGCAGGATATACGCATAGTAATGGGTATTCTAGCTTCCCTACCATACTTCCAA
GCTCTGAAACCAACACAAGCAATATCAATAATATGGTCATTGACAAAGCGGGAAATCGTATTATCGGCGATGGTGGAAAG
CGCAACTACACTATTTACGATATCCGTTTAAAGGCAGAATATGACATAAGCGATTCTGATATACTCTCAAGTATGATTAG
CTTTTCTAATCACAACTACACTTTTGGACACTTCAAAAGTTATATAAGCGATAAAAATACAGGAGAAAGCACCAATCTTG
TCAATGGCAAAGATTATTTTGTAGGTTCTGGGCTTGGTGGTATGGGGACTTATTCACACTTATTAGGGAATCTTACCTAT
CAACACGATTTTGAAGAATCTTATTTTAAAATCTCTTTTTCAACAATGAATCTATTTAGTCTTTGGCAAGATGCAAAGCA
AGGTGAGGGTGATAGATATGGTGGAGCAGGAAGCACACAAGATATAGATTCTACAAGTAATTATCTTGATATGCTTTATC
GTATCAATTTAAATGCTATACATTCTTTAAACACAGCAATGCAGTTTCGTTATTACACATTTACACAGCTTAATGCCAAT
ATGACAAATTGGAAAGACTATAAAAGCCGCACTGACGTCTATCGTAGTTATGGAGGAAAAGCCTTTGTAACTTCTGCGTA
TCTAAGTGTAGATTCAGAGTGGCTACCTAATCTTTCTTCCACTCTTGGAATGCGCTATGATTATTGGAAAAATTTTAATG
GCTATCTCTTGGATAATAATAATCCTACCACAAATCGCAATAATCAAGGAGCAATCGCCTCTGTTTTGAGCCCCAAAGCT
TCCATTAACTACGCTCCAAATTTTTTACAAGGCATAATGCTTAAAAGCTCCATTGGCTCTGGCTTTAGAATGCCAACTAT
GCGTGATATGTATCAATTCACACATTCTAACACATATTGGGAGATTAACCCTGATTTAAAGCAAGAGAGTGCATTGAGCT
TTGATATTGGTATGGAATATCAACATAAGGGATTTGAGGGAAAAATATATTATTATGATACAGAACTATGGGATATGATA
TATCGTTCTGGCACAGGCAAACAAGATAAACCTTATCAAAATGTCAATGCTGGACGAGGACGCATTCACGGCATAGAAAT
AAGCGCACAAGTGCCCATTTTTAGAGATTTGTATATAGAAAGTAATTATACCCTTACTCTTGCTACGATTCTCAAAAATA
ATGCAAAAAAAGATACAGAGGGCAAACAACTTGCAGCAACACCCAAACATATAACTAATCTAGCACTTAATTACTTCCCA
CAATATGGATTATATGCTTCAATTTGGGCGTATTATGCACCTGCATTCTATGCTGATGACCTCAATACTCCAGCTTTAAA
CAATACCTATGGCAATTATGAATCTCAATTTACTCTTAATGCCAAATGTGGTTATAACTTTAAAAATGGCATTGATTTAT
CTGCAAGTTTTATGAATATCACAAATAATCGCTTCTATGATTTTTACCAAGTAGCTGGAGCAAATTATTCCTTGCAGTTG
CGATATAAATTATAA

Upstream 100 bases:

>100_bases
CAAAAATATATATTATATCATATTATTTACATAAAAAAATAAATTAAGTAATATTTAATTTATCCTATGTCATAATAACA
TAAAATATTAAAGAGTAATA

Downstream 100 bases:

>100_bases
TTTCAAAGAAGTATTTTAGCGACCTAAAGATATAATCTCTCTTTAATTTGAAGGAGAGATTATATGCAAAAGCCACGAAT
AGTTCTTAAAATTGGCTCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 724; Mature: 724

Protein sequence:

>724_residues
MMFKTLCNLTLCVSFGYSMQSYTLNKSIITGNALATDVEKIPGNVSVIDNKQIQHMPNAKITDTIKKIAGVRVDNDVGFN
PRPKIKIRGINYGTLLMLDGVILSDLEGENRILNQISLYDVERVEVARGAFSSLYGAGAIGGVVNFITSMPTQFQSQFLI
SYGNEFINNTADKNLIRAFASVGDVFIDKRLRLKLSAGYTHSNGYSSFPTILPSSETNTSNINNMVIDKAGNRIIGDGGK
RNYTIYDIRLKAEYDISDSDILSSMISFSNHNYTFGHFKSYISDKNTGESTNLVNGKDYFVGSGLGGMGTYSHLLGNLTY
QHDFEESYFKISFSTMNLFSLWQDAKQGEGDRYGGAGSTQDIDSTSNYLDMLYRINLNAIHSLNTAMQFRYYTFTQLNAN
MTNWKDYKSRTDVYRSYGGKAFVTSAYLSVDSEWLPNLSSTLGMRYDYWKNFNGYLLDNNNPTTNRNNQGAIASVLSPKA
SINYAPNFLQGIMLKSSIGSGFRMPTMRDMYQFTHSNTYWEINPDLKQESALSFDIGMEYQHKGFEGKIYYYDTELWDMI
YRSGTGKQDKPYQNVNAGRGRIHGIEISAQVPIFRDLYIESNYTLTLATILKNNAKKDTEGKQLAATPKHITNLALNYFP
QYGLYASIWAYYAPAFYADDLNTPALNNTYGNYESQFTLNAKCGYNFKNGIDLSASFMNITNNRFYDFYQVAGANYSLQL
RYKL

Sequences:

>Translated_724_residues
MMFKTLCNLTLCVSFGYSMQSYTLNKSIITGNALATDVEKIPGNVSVIDNKQIQHMPNAKITDTIKKIAGVRVDNDVGFN
PRPKIKIRGINYGTLLMLDGVILSDLEGENRILNQISLYDVERVEVARGAFSSLYGAGAIGGVVNFITSMPTQFQSQFLI
SYGNEFINNTADKNLIRAFASVGDVFIDKRLRLKLSAGYTHSNGYSSFPTILPSSETNTSNINNMVIDKAGNRIIGDGGK
RNYTIYDIRLKAEYDISDSDILSSMISFSNHNYTFGHFKSYISDKNTGESTNLVNGKDYFVGSGLGGMGTYSHLLGNLTY
QHDFEESYFKISFSTMNLFSLWQDAKQGEGDRYGGAGSTQDIDSTSNYLDMLYRINLNAIHSLNTAMQFRYYTFTQLNAN
MTNWKDYKSRTDVYRSYGGKAFVTSAYLSVDSEWLPNLSSTLGMRYDYWKNFNGYLLDNNNPTTNRNNQGAIASVLSPKA
SINYAPNFLQGIMLKSSIGSGFRMPTMRDMYQFTHSNTYWEINPDLKQESALSFDIGMEYQHKGFEGKIYYYDTELWDMI
YRSGTGKQDKPYQNVNAGRGRIHGIEISAQVPIFRDLYIESNYTLTLATILKNNAKKDTEGKQLAATPKHITNLALNYFP
QYGLYASIWAYYAPAFYADDLNTPALNNTYGNYESQFTLNAKCGYNFKNGIDLSASFMNITNNRFYDFYQVAGANYSLQL
RYKL
>Mature_724_residues
MMFKTLCNLTLCVSFGYSMQSYTLNKSIITGNALATDVEKIPGNVSVIDNKQIQHMPNAKITDTIKKIAGVRVDNDVGFN
PRPKIKIRGINYGTLLMLDGVILSDLEGENRILNQISLYDVERVEVARGAFSSLYGAGAIGGVVNFITSMPTQFQSQFLI
SYGNEFINNTADKNLIRAFASVGDVFIDKRLRLKLSAGYTHSNGYSSFPTILPSSETNTSNINNMVIDKAGNRIIGDGGK
RNYTIYDIRLKAEYDISDSDILSSMISFSNHNYTFGHFKSYISDKNTGESTNLVNGKDYFVGSGLGGMGTYSHLLGNLTY
QHDFEESYFKISFSTMNLFSLWQDAKQGEGDRYGGAGSTQDIDSTSNYLDMLYRINLNAIHSLNTAMQFRYYTFTQLNAN
MTNWKDYKSRTDVYRSYGGKAFVTSAYLSVDSEWLPNLSSTLGMRYDYWKNFNGYLLDNNNPTTNRNNQGAIASVLSPKA
SINYAPNFLQGIMLKSSIGSGFRMPTMRDMYQFTHSNTYWEINPDLKQESALSFDIGMEYQHKGFEGKIYYYDTELWDMI
YRSGTGKQDKPYQNVNAGRGRIHGIEISAQVPIFRDLYIESNYTLTLATILKNNAKKDTEGKQLAATPKHITNLALNYFP
QYGLYASIWAYYAPAFYADDLNTPALNNTYGNYESQFTLNAKCGYNFKNGIDLSASFMNITNNRFYDFYQVAGANYSLQL
RYKL

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=126, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790405, Length=209, Percent_Identity=28.7081339712919, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 81638; Mature: 81638

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFKTLCNLTLCVSFGYSMQSYTLNKSIITGNALATDVEKIPGNVSVIDNKQIQHMPNAK
CCHHHHHCEEEEEECCCCCEEEEECCEEEECCHHHHHHHHCCCCEEEECCCHHHCCCCCH
ITDTIKKIAGVRVDNDVGFNPRPKIKIRGINYGTLLMLDGVILSDLEGENRILNQISLYD
HHHHHHHHHCEEECCCCCCCCCCCEEEEECCCCEEEEECCCCEECCCCCHHHHHHHHHCC
VERVEVARGAFSSLYGAGAIGGVVNFITSMPTQFQSQFLISYGNEFINNTADKNLIRAFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
SVGDVFIDKRLRLKLSAGYTHSNGYSSFPTILPSSETNTSNINNMVIDKAGNRIIGDGGK
HHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCC
RNYTIYDIRLKAEYDISDSDILSSMISFSNHNYTFGHFKSYISDKNTGESTNLVNGKDYF
CCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCEE
VGSGLGGMGTYSHLLGNLTYQHDFEESYFKISFSTMNLFSLWQDAKQGEGDRYGGAGSTQ
EECCCCCCHHHHHHHCCCCEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
DIDSTSNYLDMLYRINLNAIHSLNTAMQFRYYTFTQLNANMTNWKDYKSRTDVYRSYGGK
CCCCHHHHHHHHHEECCHHHHHHCHHHEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCC
AFVTSAYLSVDSEWLPNLSSTLGMRYDYWKNFNGYLLDNNNPTTNRNNQGAIASVLSPKA
EEEEEEEEECCHHHCCCCHHHHCCCCHHHCCCCCEEEECCCCCCCCCCCCCCHHHHCCCC
SINYAPNFLQGIMLKSSIGSGFRMPTMRDMYQFTHSNTYWEINPDLKQESALSFDIGMEY
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCC
QHKGFEGKIYYYDTELWDMIYRSGTGKQDKPYQNVNAGRGRIHGIEISAQVPIFRDLYIE
CCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEEE
SNYTLTLATILKNNAKKDTEGKQLAATPKHITNLALNYFPQYGLYASIWAYYAPAFYADD
CCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECC
LNTPALNNTYGNYESQFTLNAKCGYNFKNGIDLSASFMNITNNRFYDFYQVAGANYSLQL
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEE
RYKL
EEEC
>Mature Secondary Structure
MMFKTLCNLTLCVSFGYSMQSYTLNKSIITGNALATDVEKIPGNVSVIDNKQIQHMPNAK
CCHHHHHCEEEEEECCCCCEEEEECCEEEECCHHHHHHHHCCCCEEEECCCHHHCCCCCH
ITDTIKKIAGVRVDNDVGFNPRPKIKIRGINYGTLLMLDGVILSDLEGENRILNQISLYD
HHHHHHHHHCEEECCCCCCCCCCCEEEEECCCCEEEEECCCCEECCCCCHHHHHHHHHCC
VERVEVARGAFSSLYGAGAIGGVVNFITSMPTQFQSQFLISYGNEFINNTADKNLIRAFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
SVGDVFIDKRLRLKLSAGYTHSNGYSSFPTILPSSETNTSNINNMVIDKAGNRIIGDGGK
HHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCC
RNYTIYDIRLKAEYDISDSDILSSMISFSNHNYTFGHFKSYISDKNTGESTNLVNGKDYF
CCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCEE
VGSGLGGMGTYSHLLGNLTYQHDFEESYFKISFSTMNLFSLWQDAKQGEGDRYGGAGSTQ
EECCCCCCHHHHHHHCCCCEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
DIDSTSNYLDMLYRINLNAIHSLNTAMQFRYYTFTQLNANMTNWKDYKSRTDVYRSYGGK
CCCCHHHHHHHHHEECCHHHHHHCHHHEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCC
AFVTSAYLSVDSEWLPNLSSTLGMRYDYWKNFNGYLLDNNNPTTNRNNQGAIASVLSPKA
EEEEEEEEECCHHHCCCCHHHHCCCCHHHCCCCCEEEECCCCCCCCCCCCCCHHHHCCCC
SINYAPNFLQGIMLKSSIGSGFRMPTMRDMYQFTHSNTYWEINPDLKQESALSFDIGMEY
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCC
QHKGFEGKIYYYDTELWDMIYRSGTGKQDKPYQNVNAGRGRIHGIEISAQVPIFRDLYIE
CCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEEE
SNYTLTLATILKNNAKKDTEGKQLAATPKHITNLALNYFPQYGLYASIWAYYAPAFYADD
CCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECC
LNTPALNNTYGNYESQFTLNAKCGYNFKNGIDLSASFMNITNNRFYDFYQVAGANYSLQL
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEE
RYKL
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]