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The map label for this gene is ureA

Identifier: 32265906

GI number: 32265906

Start: 391929

End: 392606

Strand: Direct

Name: ureA

Synonym: HH0407

Alternate gene names: 32265906

Gene position: 391929-392606 (Clockwise)

Preceding gene: 32265905

Following gene: 32265907

Centisome position: 21.78

GC content: 36.58

Gene sequence:

>678_bases
ATGAGATTAACGCCTAAAGAATTAGACAAATTAATGTTGCATTATGCTGGGGCACTAGCCAAAAGTCGCAAAGAACGAGG
TATTAAACTTAATTATGTTGAATCTATAGCCCTTATTAGTATGGAGATTATGGAGCTTGCGCGCGAGGGTAACAAAAGTG
TAGCAGAGCTTATGCAACAAGGCAGAGAGATTCTCAAAGCCGATGAAGTAATGGAGGGTGTAGCAAGTATGGTTAATGAA
GTGCAGGTAGAAGTGAGTTTCCCCGATGGAACAAAGCTTGTTACGATTCATAATCCTATTGAAGATAATGGCAAACTTAC
TCCCGGAGAGTATATTCTCAAAGATGAAGACATTACGCTCAATGCCAATAAAGAATCTATAAGTATTAAAGTTACTCATA
AGGGCGATAGACCTATACAAGTAGGTTCACATTTTCATTTTTTTGAAGTCAATGCACTTTTGGAATTTGATAGAGCCCAA
GCATTTGGTAAACGTTTAGATATTGCCTCTGGCACATCAGTGCGTTTTGAGCCGGGTGAAGAAAAAAATGTGAATCTTAT
TGATTTTGGAGGCAAACAAAAAATTATTGGATTTAATGACTTAACGAATGCGCATATAAATAAAGAAAATAAAGAGCAAT
GCCTTGCAAATGCAGCACAAAAACATTTTATACACTAA

Upstream 100 bases:

>100_bases
TTGTTATAAACACACTATTTAATAAGTATTTATCATAAGCTTTTACAATCCTCGCGCCTCTTAAGAGACTTTAAAATTAT
AAAATATTTAAGGAGAGAGT

Downstream 100 bases:

>100_bases
ATTTATATTCAAGGAGAGAAAATGATTAAGATTTCAAGAAAACAATATGCCTCTATGTATGGACCAACCACAGGTGATAA
AGTGCGCTTAGGCGATACAA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRLTPKELDKLMLHYAGALAKSRKERGIKLNYVESIALISMEIMELAREGNKSVAELMQQGREILKADEVMEGVASMVNE
VQVEVSFPDGTKLVTIHNPIEDNGKLTPGEYILKDEDITLNANKESISIKVTHKGDRPIQVGSHFHFFEVNALLEFDRAQ
AFGKRLDIASGTSVRFEPGEEKNVNLIDFGGKQKIIGFNDLTNAHINKENKEQCLANAAQKHFIH

Sequences:

>Translated_225_residues
MRLTPKELDKLMLHYAGALAKSRKERGIKLNYVESIALISMEIMELAREGNKSVAELMQQGREILKADEVMEGVASMVNE
VQVEVSFPDGTKLVTIHNPIEDNGKLTPGEYILKDEDITLNANKESISIKVTHKGDRPIQVGSHFHFFEVNALLEFDRAQ
AFGKRLDIASGTSVRFEPGEEKNVNLIDFGGKQKIIGFNDLTNAHINKENKEQCLANAAQKHFIH
>Mature_225_residues
MRLTPKELDKLMLHYAGALAKSRKERGIKLNYVESIALISMEIMELAREGNKSVAELMQQGREILKADEVMEGVASMVNE
VQVEVSFPDGTKLVTIHNPIEDNGKLTPGEYILKDEDITLNANKESISIKVTHKGDRPIQVGSHFHFFEVNALLEFDRAQ
AFGKRLDIASGTSVRFEPGEEKNVNLIDFGGKQKIIGFNDLTNAHINKENKEQCLANAAQKHFIH

Specific function: Unknown

COG id: COG0832

COG function: function code E; Urea amidohydrolase (urease) beta subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the urease beta subunit family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE23_HELHP (Q93PJ5)

Other databases:

- EMBL:   AF332656
- EMBL:   AE017125
- EMBL:   AF066862
- EMBL:   AF066863
- EMBL:   AF066864
- RefSeq:   NP_859938.1
- ProteinModelPortal:   Q93PJ5
- SMR:   Q93PJ5
- GeneID:   1493461
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0407
- NMPDR:   fig|235279.1.peg.407
- HOGENOM:   HBG365918
- OMA:   VHHPIRG
- ProtClustDB:   PRK13986
- BioCyc:   HHEP235279:HH_0407-MONOMER
- BRENDA:   3.5.1.5
- GO:   GO:0005737
- HAMAP:   MF_01955
- InterPro:   IPR002026
- InterPro:   IPR002019
- InterPro:   IPR008223
- Gene3D:   G3DSA:2.10.150.10
- Gene3D:   G3DSA:3.30.280.10
- PIRSF:   PIRSF001225
- ProDom:   PD002319
- TIGRFAMs:   TIGR00192
- TIGRFAMs:   TIGR00193

Pfam domain/function: PF00699 Urease_beta; PF00547 Urease_gamma; SSF51278 Urease_beta; SSF54111 Urease_gamma_reg

EC number: =3.5.1.5

Molecular weight: Translated: 25198; Mature: 25198

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTPKELDKLMLHYAGALAKSRKERGIKLNYVESIALISMEIMELAREGNKSVAELMQQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GREILKADEVMEGVASMVNEVQVEVSFPDGTKLVTIHNPIEDNGKLTPGEYILKDEDITL
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEE
NANKESISIKVTHKGDRPIQVGSHFHFFEVNALLEFDRAQAFGKRLDIASGTSVRFEPGE
ECCCCEEEEEEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
EKNVNLIDFGGKQKIIGFNDLTNAHINKENKEQCLANAAQKHFIH
CCCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLTPKELDKLMLHYAGALAKSRKERGIKLNYVESIALISMEIMELAREGNKSVAELMQQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GREILKADEVMEGVASMVNEVQVEVSFPDGTKLVTIHNPIEDNGKLTPGEYILKDEDITL
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEE
NANKESISIKVTHKGDRPIQVGSHFHFFEVNALLEFDRAQAFGKRLDIASGTSVRFEPGE
ECCCCEEEEEEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
EKNVNLIDFGGKQKIIGFNDLTNAHINKENKEQCLANAAQKHFIH
CCCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11500473; 12810954; 9705372