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The map label for this gene is ureB

Identifier: 32265907

GI number: 32265907

Start: 392628

End: 394337

Strand: Direct

Name: ureB

Synonym: HH0408

Alternate gene names: 32265907

Gene position: 392628-394337 (Clockwise)

Preceding gene: 32265906

Following gene: 32265908

Centisome position: 21.82

GC content: 38.65

Gene sequence:

>1710_bases
ATGATTAAGATTTCAAGAAAACAATATGCCTCTATGTATGGACCAACCACAGGTGATAAAGTGCGCTTAGGCGATACAAA
CTTATTTGCAGAAATTGAAAAAGATTATACCCTTTATGGTGAAGAGATTAAATTTGGCGGAGGAAAAACTATCCGCGATG
GTATGGCACAAAGCGCAAGCACTTATACAAATGAGCTTGATGCAGTCATCACAAATGCAATGATTATTGATTATACAGGG
ATTTACAAAGCTGATATTGGCATTAAGGGTGGAAAAATCGTAGGCATTGGTAAAGCGGGAAATCCAGACACGCAAGATAG
TGTAAATGAGGCAATGGTTGTAGGTGCTGCAACAGAAGTTATAGCAGGAGAAGGACAAATTATTACAGCGGGTGGAATTG
ATACACATATTCACTTTATCTCTCCTACACAAATCCCAACTGCACTTTATAGCGGTGTAACAACGATGATTGGTGGAGGC
ACAGGACCTGCAGCAGGCACAAACGCTACTACCTGCACACCCGGAAAATGGAATATGCACCAAATGTTGCGTGCTGCTGA
AAGCTATGCTATGAATCTAGGATTTTTTGGCAAAGGCAATAGCTCTAATGAAGAAGGATTAGAAGAGCAAATTAAAGCTG
GAGCATTGGGATTAAAGGTTCACGAAGATTGGGGTTCTACTCCTGCTGCAATTAACCACGCTCTCAATGTTGCCCAAAAA
TATGATGTGCAAGTAGCTATTCACACAGATACACTCAATGAAGCAGGCTGTGTTGAAGACACAATGAAAGCAATTGATGG
CAGAACTATCCATACATTCCATACAGAAGGTGCTGGTGGAGGACACGCTCCAGATATTATTAAAGCTGCAGGAGAACCAA
ATATTCTCCCTGCTTCTACAAATCCCACCATTCCATTTACAAAAAATACAGCTGATGAGCATTTGGATATGCTTATGGTA
TGTCATCACTTAGATAAAAAAATTAAAGAAGATGTGGCTTTTGCTGATAGCAGAATCCGCCCAGAAACCATCGCCGCAGA
AGATACGCTTCACGATATGGGGATTTTCTCAATCACAAGCTCAGATTCTCAAGCTATGGGGAGAGTGGGTGAAGTCATCA
CAAGGACTTGGCAAACTGCCGATAAATGCAAAAATGAATTTGGAGCCTTAAAAGAAGAATGCGGCGAAAATGATAACTTT
AGAATCAAAAGATATATTTCAAAATACACTATCAATCCAGCTATTGCTCACGGGATTTCAGAATATGTAGGTTCTGTTGA
AGTGGGTAAATTTGCTGATTTAGTTCTTTGGAAACCAAGTATGTTTGGCATAAAGCCAGAGATGATACTCAAAAATGGAA
TGATTGTAGCAGCAAAAATAGGGGATTCTAATGCTTCTATTCCTACTCCTGAACCTGTCGTATATGCCCCAATGTTTGGC
AGCTATGGCAAAGCAAAGTATAATTGTGCGATCACTTTTGTCTCAAAAATTGCCTATGATTGTCATATCAAAGAGGAACT
TGGGCTTGAAAGAATACTTTTGCCTGTAAAAAATTGTCGCAATATTACAAAAAAAGATATGAAATTTAATGATGTCATCA
CACCCATTGAAGTGAATCCAGAAACTTATGAAGTAAGAGTAAATAATACAAAAATTACTTCTAAGCCTGTTGAAAAGGTA
TCTTTAGGGCAACTTTATTGTTTATTTTAA

Upstream 100 bases:

>100_bases
CTTAACGAATGCGCATATAAATAAAGAAAATAAAGAGCAATGCCTTGCAAATGCAGCACAAAAACATTTTATACACTAAA
TTTATATTCAAGGAGAGAAA

Downstream 100 bases:

>100_bases
GGAGAAAATATGCTAGGAATTGTATTAATGTATGTAGCTATTGTTTTAATTAATAATGGTATTTGCCGCCTCACTCATAT
TGATGGAAAAAGTGCTTCAA

Product: urease subunit beta

Products: NA

Alternate protein names: Urea amidohydrolase subunit beta

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSASTYTNELDAVITNAMIIDYTG
IYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEVIAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGG
TGPAAGTNATTCTPGKWNMHQMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK
YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPASTNPTIPFTKNTADEHLDMLMV
CHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNF
RIKRYISKYTINPAIAHGISEYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG
SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNPETYEVRVNNTKITSKPVEKV
SLGQLYCLF

Sequences:

>Translated_569_residues
MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSASTYTNELDAVITNAMIIDYTG
IYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEVIAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGG
TGPAAGTNATTCTPGKWNMHQMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK
YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPASTNPTIPFTKNTADEHLDMLMV
CHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNF
RIKRYISKYTINPAIAHGISEYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG
SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNPETYEVRVNNTKITSKPVEKV
SLGQLYCLF
>Mature_569_residues
MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSASTYTNELDAVITNAMIIDYTG
IYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEVIAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGG
TGPAAGTNATTCTPGKWNMHQMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK
YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPASTNPTIPFTKNTADEHLDMLMV
CHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNF
RIKRYISKYTINPAIAHGISEYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG
SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNPETYEVRVNNTKITSKPVEKV
SLGQLYCLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_HELHP (Q93PJ4)

Other databases:

- EMBL:   AF332656
- EMBL:   AE017125
- RefSeq:   NP_859939.1
- ProteinModelPortal:   Q93PJ4
- SMR:   Q93PJ4
- MEROPS:   M38.982
- GeneID:   1493462
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0408
- NMPDR:   fig|235279.1.peg.408
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13985
- BioCyc:   HHEP235279:HH_0408-MONOMER
- BRENDA:   3.5.1.5
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61511; Mature: 61511

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 322-322 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSAS
CEEECHHHHHHHCCCCCCCEEEECCCCEEEEECCCEEEECCEEEECCCCHHHHHHHHHHH
TYTNELDAVITNAMIIDYTGIYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEV
HHHHHHHHHHHCEEEEEECCEEEECCCCCCCEEEEECCCCCCCCHHHHHHEEEEECHHHE
IAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGGTGPAAGTNATTCTPGKWNMH
EECCCCEEEECCCEEEEEEECCCCHHHHHHHCHHHEECCCCCCCCCCCCCCCCCCCCCHH
QMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK
HHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH
YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPAST
EEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCCEEECCC
NPTIPFTKNTADEHLDMLMVCHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNFRIKRYISKYTINPAIAHGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHEEEHHHHCCCHHHHHHHH
EYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG
HHHCCCCCCCCEEEEEECCHHCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCEEEECCCC
SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNP
CCCCCEEEEEEEEEEHHHHHEEEHHHCCHHHHHHHHHHHHCHHHHCCCHHHCCCEEEECC
ETYEVRVNNTKITSKPVEKVSLGQLYCLF
CEEEEEECCEEECCCCCCHHCCCEEEEEC
>Mature Secondary Structure
MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSAS
CEEECHHHHHHHCCCCCCCEEEECCCCEEEEECCCEEEECCEEEECCCCHHHHHHHHHHH
TYTNELDAVITNAMIIDYTGIYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEV
HHHHHHHHHHHCEEEEEECCEEEECCCCCCCEEEEECCCCCCCCHHHHHHEEEEECHHHE
IAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGGTGPAAGTNATTCTPGKWNMH
EECCCCEEEECCCEEEEEEECCCCHHHHHHHCHHHEECCCCCCCCCCCCCCCCCCCCCHH
QMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK
HHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH
YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPAST
EEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCCEEECCC
NPTIPFTKNTADEHLDMLMVCHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNFRIKRYISKYTINPAIAHGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHEEEHHHHCCCHHHHHHHH
EYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG
HHHCCCCCCCCEEEEEECCHHCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCEEEECCCC
SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNP
CCCCCEEEEEEEEEEHHHHHEEEHHHCCHHHHHHHHHHHHCHHHHCCCHHHCCCEEEECC
ETYEVRVNNTKITSKPVEKVSLGQLYCLF
CEEEEEECCEEECCCCCCHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11500473; 12810954