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The map label for this gene is murC

Identifier: 32265872

GI number: 32265872

Start: 364346

End: 365665

Strand: Direct

Name: murC

Synonym: HH0373

Alternate gene names: 32265872

Gene position: 364346-365665 (Clockwise)

Preceding gene: 32265871

Following gene: 32265873

Centisome position: 20.25

GC content: 37.58

Gene sequence:

>1320_bases
ATGAAAATACATTTCATAGGTATTGGTGGCATTGGTATTTCAGGCTTAGCAAAATACCTCCGCGCACAAGGCATAGAAGT
GAGTGGGTCTGATATTGCAGAGGGAAATGCCACAAAATATCTCCGCGCACAAGGTGTGCCTATTCATATTCCTCATAGTG
CTGCTGCTATTACCAATCAAGATGTAGTGATTCATTCAGCTATCATTAAGCCTGATAATATTGAAGTGCAAGAGGCAATA
AAAAAAGGTATTAAAGTCCTTTCACGCAAAGAAGCCATTGCTTCTATTCTTAAAGAAAAACGCGTCTTTAGCGTATGTGG
TGCGCACGGCAAATCCACCACAAGTGCGATTTTAAGTGCGATTTTTCCACAATTTGGTGCAATTATTGGTGCAGATTCTA
AAGAGTTTGGCTCAAATGTGCGTGAAACGAAAAGTGAAAGCATTGTTTTTGAAGCTGATGAATCTGATAAAAGCTTTTTA
AACTCAAATCCTTATTGTGCGATTATCCCAAATGCCGAGCCAGAGCATATGGAGAGCTATAATCACGACTTAAAGGAATT
TTATGGTGCATATTATGAATTCATTTGTAAAGCAAAAAAACGCATTTTAAACCTAAGCGACCCTTATTTACAAAGCCTTA
CAGATATAGAATCTATCACACTTTGCCCTGATAAAGACATTAAAGACATACGCTTTAATCTCCATAATGATGAACCTCAA
ACAACTTTTAGCCTCAAAAACTATGGAGAGTTTAGTGTATGGGGCTTTGGAGAGCATATGGCACAAAATGCGAGTTTAGC
TATTTTATGTGCGCTTGATGAGCTCGGTATTGATGCTTTGACAACAATAAAAGAGAATCTCACACATTTTAAGGGCATTA
AAAAACGTTTTGATATTCTTACTAAAGGCACAACAACGATTATTGACGATTATGCCCACCACCCCACAGAAATTCTCGCT
ACACTCAAAAGCGTAGCGATTTATAACTCGCTTAAACCCCATAATAAAGTCATTGCCATTTGGCAGCCTCATAAATACTC
GCGTGTGCTTGATAATTTACAAGCTTTCATAGATTGTTTTAGCAATGCGTGTGATGAGCTTGTAATTTTGCCTGTGTGGA
AAGCTGGAGAGGAACATATAGATATTGATTTTGCCACACTTTTTGCACATTATAATCCCACTTTTGCTACACATCTTAAG
CGAGAAGATTCTCAAATCCACCTCTATGATGGAAACAATCTCATTAAAACCTTGCAAGATGCTCTTATTATCGGACTTGG
TGCAGGAGATATTACTTATCAATTACGAGGAGAAAAATAA

Upstream 100 bases:

>100_bases
AAGGCTATGTAAGAATCGCTCTTGTGTATGATAATAATACAACAAAAAAAGCACTTCTTGCCCTTAAAGAAGCAATCAAA
CTTTATAAACAGGAGTGTCA

Downstream 100 bases:

>100_bases
TGGGCTATATTATTTTCATACTTCTATTGGTGTTCTTTGTGGTAGTTGGAGTTATATTAACGCAAAACAAAGACAAAATA
CCGCGCAAAACAAAAATTGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKIHFIGIGGIGISGLAKYLRAQGIEVSGSDIAEGNATKYLRAQGVPIHIPHSAAAITNQDVVIHSAIIKPDNIEVQEAI
KKGIKVLSRKEAIASILKEKRVFSVCGAHGKSTTSAILSAIFPQFGAIIGADSKEFGSNVRETKSESIVFEADESDKSFL
NSNPYCAIIPNAEPEHMESYNHDLKEFYGAYYEFICKAKKRILNLSDPYLQSLTDIESITLCPDKDIKDIRFNLHNDEPQ
TTFSLKNYGEFSVWGFGEHMAQNASLAILCALDELGIDALTTIKENLTHFKGIKKRFDILTKGTTTIIDDYAHHPTEILA
TLKSVAIYNSLKPHNKVIAIWQPHKYSRVLDNLQAFIDCFSNACDELVILPVWKAGEEHIDIDFATLFAHYNPTFATHLK
REDSQIHLYDGNNLIKTLQDALIIGLGAGDITYQLRGEK

Sequences:

>Translated_439_residues
MKIHFIGIGGIGISGLAKYLRAQGIEVSGSDIAEGNATKYLRAQGVPIHIPHSAAAITNQDVVIHSAIIKPDNIEVQEAI
KKGIKVLSRKEAIASILKEKRVFSVCGAHGKSTTSAILSAIFPQFGAIIGADSKEFGSNVRETKSESIVFEADESDKSFL
NSNPYCAIIPNAEPEHMESYNHDLKEFYGAYYEFICKAKKRILNLSDPYLQSLTDIESITLCPDKDIKDIRFNLHNDEPQ
TTFSLKNYGEFSVWGFGEHMAQNASLAILCALDELGIDALTTIKENLTHFKGIKKRFDILTKGTTTIIDDYAHHPTEILA
TLKSVAIYNSLKPHNKVIAIWQPHKYSRVLDNLQAFIDCFSNACDELVILPVWKAGEEHIDIDFATLFAHYNPTFATHLK
REDSQIHLYDGNNLIKTLQDALIIGLGAGDITYQLRGEK
>Mature_439_residues
MKIHFIGIGGIGISGLAKYLRAQGIEVSGSDIAEGNATKYLRAQGVPIHIPHSAAAITNQDVVIHSAIIKPDNIEVQEAI
KKGIKVLSRKEAIASILKEKRVFSVCGAHGKSTTSAILSAIFPQFGAIIGADSKEFGSNVRETKSESIVFEADESDKSFL
NSNPYCAIIPNAEPEHMESYNHDLKEFYGAYYEFICKAKKRILNLSDPYLQSLTDIESITLCPDKDIKDIRFNLHNDEPQ
TTFSLKNYGEFSVWGFGEHMAQNASLAILCALDELGIDALTTIKENLTHFKGIKKRFDILTKGTTTIIDDYAHHPTEILA
TLKSVAIYNSLKPHNKVIAIWQPHKYSRVLDNLQAFIDCFSNACDELVILPVWKAGEEHIDIDFATLFAHYNPTFATHLK
REDSQIHLYDGNNLIKTLQDALIIGLGAGDITYQLRGEK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=403, Percent_Identity=31.2655086848635, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790680, Length=366, Percent_Identity=26.775956284153, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 48721; Mature: 48721

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHFIGIGGIGISGLAKYLRAQGIEVSGSDIAEGNATKYLRAQGVPIHIPHSAAAITNQ
CEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEECCCCHHHCCCC
DVVIHSAIIKPDNIEVQEAIKKGIKVLSRKEAIASILKEKRVFSVCGAHGKSTTSAILSA
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IFPQFGAIIGADSKEFGSNVRETKSESIVFEADESDKSFLNSNPYCAIIPNAEPEHMESY
HHHHHHHEECCCCHHHCCCHHHCCCCCEEEECCCCCHHHHCCCCEEEECCCCCHHHHHHH
NHDLKEFYGAYYEFICKAKKRILNLSDPYLQSLTDIESITLCPDKDIKDIRFNLHNDEPQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCHHEEEECCCCCC
TTFSLKNYGEFSVWGFGEHMAQNASLAILCALDELGIDALTTIKENLTHFKGIKKRFDIL
CEEEECCCCCEEEEECHHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TKGTTTIIDDYAHHPTEILATLKSVAIYNSLKPHNKVIAIWQPHKYSRVLDNLQAFIDCF
HCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
SNACDELVILPVWKAGEEHIDIDFATLFAHYNPTFATHLKREDSQIHLYDGNNLIKTLQD
HHCCCCEEEEEEECCCCCEEEEEHHHHHHHCCCHHHHHHCCCCCEEEEECCCHHHHHHHH
ALIIGLGAGDITYQLRGEK
HHEEEECCCCEEEEEECCC
>Mature Secondary Structure
MKIHFIGIGGIGISGLAKYLRAQGIEVSGSDIAEGNATKYLRAQGVPIHIPHSAAAITNQ
CEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEECCCCHHHCCCC
DVVIHSAIIKPDNIEVQEAIKKGIKVLSRKEAIASILKEKRVFSVCGAHGKSTTSAILSA
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IFPQFGAIIGADSKEFGSNVRETKSESIVFEADESDKSFLNSNPYCAIIPNAEPEHMESY
HHHHHHHEECCCCHHHCCCHHHCCCCCEEEECCCCCHHHHCCCCEEEECCCCCHHHHHHH
NHDLKEFYGAYYEFICKAKKRILNLSDPYLQSLTDIESITLCPDKDIKDIRFNLHNDEPQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCHHEEEECCCCCC
TTFSLKNYGEFSVWGFGEHMAQNASLAILCALDELGIDALTTIKENLTHFKGIKKRFDIL
CEEEECCCCCEEEEECHHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TKGTTTIIDDYAHHPTEILATLKSVAIYNSLKPHNKVIAIWQPHKYSRVLDNLQAFIDCF
HCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
SNACDELVILPVWKAGEEHIDIDFATLFAHYNPTFATHLKREDSQIHLYDGNNLIKTLQD
HHCCCCEEEEEEECCCCCEEEEEHHHHHHHCCCHHHHHHCCCCCEEEEECCCHHHHHHHH
ALIIGLGAGDITYQLRGEK
HHEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA