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The map label for this gene is ppiC [C]

Identifier: 32265604

GI number: 32265604

Start: 104073

End: 104903

Strand: Direct

Name: ppiC [C]

Synonym: HH0105

Alternate gene names: 32265604

Gene position: 104073-104903 (Clockwise)

Preceding gene: 32265603

Following gene: 32265605

Centisome position: 5.78

GC content: 34.18

Gene sequence:

>831_bases
ATGAAACAGCAACTTCTCGCCACAATACTTTTCTCTCTTGTGTGCGTATCTCTTCAAGCCAAAACCTACGCAACGGTTGA
TGGTGTAGCAATTACAGACAAAGATATGGAAATTCTCAAACAAAGTATCCCAAACTTCAACTATAATAAGCTTTCTGAGC
AAGAAAAAGAAATGCTCATTAATGAGCTTATAAATAGGCAACTTATTCTTAAAGCTGCTAAACAAGAAAAACTAGATACT
TCTAAAGAATATACTGATACCATTAATAGCATTAAAGATAATCTCCTTATTGATTTATGGACAAAAAAACAAGCCAATAG
CACGCAAGTCCCTACAATGAATGATGCTCAACTTCGTAAAATTTACCAAGAAAATGAAGGAGAATTTATTGACCAAGAAG
GTAAAGCACGACATATTCTTGTAAAATCAGAATCTGAAGCAAAAGAAATTATCAAAGAGCTTGATAAAGTAGGTAAAGCA
AAGGCAGAAGCGAAATTCATAGAACTTGCAAATGCAAAATCGATTGACCCAGCTTCAAAACAACAAAAAAATGGTGGGGA
TTTAGGCGTATTTAAACGTGCGGGTATGGATCCTATGTTTTCTAAAGCTGCTTTTGACTTAAAACCGGGCACTTACACAA
AAGAGCCTGTTCTTACGCAATTTGGCTATCATATTATCTATCTTGAACGCAAAAGTGAGCCTAAGGTCATTCCCTATAAA
GATGCTAAAAAAATTATTGAAAATAGCATCAAAATGCAAAGTATTCAAGGTGGTATGATGCAAAAGATTCAGGCTTTACG
CGCTAAAGCTAAAATCAAAATTACAAAATAA

Upstream 100 bases:

>100_bases
AAACTTAATACTTCCTCATTATGATATAGGAAGCGCTTAGCTTACAATATATTTAGCTTTATTTGATACAATCGCACAAT
CTTAATTATGGAGCAATATT

Downstream 100 bases:

>100_bases
ATCATTTAAAATCAAGAAAGGAGGGGCTATGCTCGTTTCAGGTAGTGAAATATTACTCAAAGCACATAAGGAAGGTTATG
GGGTAGGTGCATTTAATTTT

Product: hypothetical protein

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKQQLLATILFSLVCVSLQAKTYATVDGVAITDKDMEILKQSIPNFNYNKLSEQEKEMLINELINRQLILKAAKQEKLDT
SKEYTDTINSIKDNLLIDLWTKKQANSTQVPTMNDAQLRKIYQENEGEFIDQEGKARHILVKSESEAKEIIKELDKVGKA
KAEAKFIELANAKSIDPASKQQKNGGDLGVFKRAGMDPMFSKAAFDLKPGTYTKEPVLTQFGYHIIYLERKSEPKVIPYK
DAKKIIENSIKMQSIQGGMMQKIQALRAKAKIKITK

Sequences:

>Translated_276_residues
MKQQLLATILFSLVCVSLQAKTYATVDGVAITDKDMEILKQSIPNFNYNKLSEQEKEMLINELINRQLILKAAKQEKLDT
SKEYTDTINSIKDNLLIDLWTKKQANSTQVPTMNDAQLRKIYQENEGEFIDQEGKARHILVKSESEAKEIIKELDKVGKA
KAEAKFIELANAKSIDPASKQQKNGGDLGVFKRAGMDPMFSKAAFDLKPGTYTKEPVLTQFGYHIIYLERKSEPKVIPYK
DAKKIIENSIKMQSIQGGMMQKIQALRAKAKIKITK
>Mature_276_residues
MKQQLLATILFSLVCVSLQAKTYATVDGVAITDKDMEILKQSIPNFNYNKLSEQEKEMLINELINRQLILKAAKQEKLDT
SKEYTDTINSIKDNLLIDLWTKKQANSTQVPTMNDAQLRKIYQENEGEFIDQEGKARHILVKSESEAKEIIKELDKVGKA
KAEAKFIELANAKSIDPASKQQKNGGDLGVFKRAGMDPMFSKAAFDLKPGTYTKEPVLTQFGYHIIYLERKSEPKVIPYK
DAKKIIENSIKMQSIQGGMMQKIQALRAKAKIKITK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 31246; Mature: 31246

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQLLATILFSLVCVSLQAKTYATVDGVAITDKDMEILKQSIPNFNYNKLSEQEKEMLI
CHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
NELINRQLILKAAKQEKLDTSKEYTDTINSIKDNLLIDLWTKKQANSTQVPTMNDAQLRK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHH
IYQENEGEFIDQEGKARHILVKSESEAKEIIKELDKVGKAKAEAKFIELANAKSIDPASK
HHHHCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QQKNGGDLGVFKRAGMDPMFSKAAFDLKPGTYTKEPVLTQFGYHIIYLERKSEPKVIPYK
HHCCCCCCCHHHHCCCCHHHHHHHEECCCCCCCCCCHHHHCCCEEEEEEECCCCCCCCHH
DAKKIIENSIKMQSIQGGMMQKIQALRAKAKIKITK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEECC
>Mature Secondary Structure
MKQQLLATILFSLVCVSLQAKTYATVDGVAITDKDMEILKQSIPNFNYNKLSEQEKEMLI
CHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
NELINRQLILKAAKQEKLDTSKEYTDTINSIKDNLLIDLWTKKQANSTQVPTMNDAQLRK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHH
IYQENEGEFIDQEGKARHILVKSESEAKEIIKELDKVGKAKAEAKFIELANAKSIDPASK
HHHHCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QQKNGGDLGVFKRAGMDPMFSKAAFDLKPGTYTKEPVLTQFGYHIIYLERKSEPKVIPYK
HHCCCCCCCHHHHCCCCHHHHHHHEECCCCCCCCCCHHHHCCCEEEEEEECCCCCCCCHH
DAKKIIENSIKMQSIQGGMMQKIQALRAKAKIKITK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]