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The map label for this gene is hemD

Identifier: 32265603

GI number: 32265603

Start: 103256

End: 103996

Strand: Direct

Name: hemD

Synonym: HH0104

Alternate gene names: NA

Gene position: 103256-103996 (Clockwise)

Preceding gene: 32265602

Following gene: 32265604

Centisome position: 5.74

GC content: 38.19

Gene sequence:

>741_bases
ATGACAGATTCTAAGTTAAATGATAAAGATATGCAAAATGCAGATGCTATCTATGAGGTAGTTCTTGTTGGGACGCGTGC
TCATCAAGGTGTTAAAAGCCTTATAAGCAATGTTATAGAATCTATTCCTATTACACATACCCTAAAAGGTATTGATGCGC
TTATTTTTACTTCCTCTTATGCGATAACTTCTCTTATAGAATCTGCCTCACCCAAATCCATTTCATACAATCCCAATCTT
GCACATTGGCGAGAAATTCCAAGCTTTGTTATTAGTCCCTCAAGCGCTGCATTATTGCACAAGGAAAATGCCTCTATTGC
TTTTGTTGGCAAAAAGGCTCACGGAAAAGAGTTTGCTAAAGAAATTATCCCGCTTTTGCAAGGGCGCACACCACTTTATC
TTCGCGCTCAAAAGATTATATCTGGGCTAGATTCTCTACTCAAAAATGCGAATATTCCCCTTCAAGAAGCAATTGCTTAT
ATTAATCATTCTCAAATTTTACCCCCTTCTCTTAAGCCTAAACCCAAAAGTGTGCTTATTTTTAGCGCACCGAGTGCATA
TGAAAGTTTTATAACAAATTTTGGGTGGGATTCACATTATGTGGCAGTAGCTATTGGGCGAAGCACTTTTGCCCACTTTG
AGGAAGGTATAAACGCATATATCAGCCCTATCCCAACTATTAGCTCTTGCATTGATTTTGCACGTAGTCTTGCACAGAAA
CTTAATACTTCCTCATTATGA

Upstream 100 bases:

>100_bases
ACACTCATAAGCCTTATACTTGGCATTATCCTTATTTTAAGTGGTGGCATAGGCTTGTATTTTTGGAATACTTTGAGAAA
AACAGGTATATAGAGATAAT

Downstream 100 bases:

>100_bases
TATAGGAAGCGCTTAGCTTACAATATATTTAGCTTTATTTGATACAATCGCACAATCTTAATTATGGAGCAATATTATGA
AACAGCAACTTCTCGCCACA

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase HemD; Uroporphyrinogen-III Synthetase; Uroporphyrinogen III Cosynthase; Uroporphyrinogen III Cosynthase HemD

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTDSKLNDKDMQNADAIYEVVLVGTRAHQGVKSLISNVIESIPITHTLKGIDALIFTSSYAITSLIESASPKSISYNPNL
AHWREIPSFVISPSSAALLHKENASIAFVGKKAHGKEFAKEIIPLLQGRTPLYLRAQKIISGLDSLLKNANIPLQEAIAY
INHSQILPPSLKPKPKSVLIFSAPSAYESFITNFGWDSHYVAVAIGRSTFAHFEEGINAYISPIPTISSCIDFARSLAQK
LNTSSL

Sequences:

>Translated_246_residues
MTDSKLNDKDMQNADAIYEVVLVGTRAHQGVKSLISNVIESIPITHTLKGIDALIFTSSYAITSLIESASPKSISYNPNL
AHWREIPSFVISPSSAALLHKENASIAFVGKKAHGKEFAKEIIPLLQGRTPLYLRAQKIISGLDSLLKNANIPLQEAIAY
INHSQILPPSLKPKPKSVLIFSAPSAYESFITNFGWDSHYVAVAIGRSTFAHFEEGINAYISPIPTISSCIDFARSLAQK
LNTSSL
>Mature_245_residues
TDSKLNDKDMQNADAIYEVVLVGTRAHQGVKSLISNVIESIPITHTLKGIDALIFTSSYAITSLIESASPKSISYNPNLA
HWREIPSFVISPSSAALLHKENASIAFVGKKAHGKEFAKEIIPLLQGRTPLYLRAQKIISGLDSLLKNANIPLQEAIAYI
NHSQILPPSLKPKPKSVLIFSAPSAYESFITNFGWDSHYVAVAIGRSTFAHFEEGINAYISPIPTISSCIDFARSLAQKL
NTSSL

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 26804; Mature: 26673

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSKLNDKDMQNADAIYEVVLVGTRAHQGVKSLISNVIESIPITHTLKGIDALIFTSSY
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AITSLIESASPKSISYNPNLAHWREIPSFVISPSSAALLHKENASIAFVGKKAHGKEFAK
HHHHHHHCCCCCCCCCCCCHHHHHHCCHHEECCCCCEEEEECCCCEEEEECCHHHHHHHH
EIIPLLQGRTPLYLRAQKIISGLDSLLKNANIPLQEAIAYINHSQILPPSLKPKPKSVLI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
FSAPSAYESFITNFGWDSHYVAVAIGRSTFAHFEEGINAYISPIPTISSCIDFARSLAQK
EECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNTSSL
HCCCCC
>Mature Secondary Structure 
TDSKLNDKDMQNADAIYEVVLVGTRAHQGVKSLISNVIESIPITHTLKGIDALIFTSSY
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AITSLIESASPKSISYNPNLAHWREIPSFVISPSSAALLHKENASIAFVGKKAHGKEFAK
HHHHHHHCCCCCCCCCCCCHHHHHHCCHHEECCCCCEEEEECCCCEEEEECCHHHHHHHH
EIIPLLQGRTPLYLRAQKIISGLDSLLKNANIPLQEAIAYINHSQILPPSLKPKPKSVLI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
FSAPSAYESFITNFGWDSHYVAVAIGRSTFAHFEEGINAYISPIPTISSCIDFARSLAQK
EECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNTSSL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA