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The map label for this gene is moeA_1

Identifier: 32265544

GI number: 32265544

Start: 48725

End: 49975

Strand: Direct

Name: moeA_1

Synonym: HH0045

Alternate gene names: 32265544

Gene position: 48725-49975 (Clockwise)

Preceding gene: 32265543

Following gene: 32265545

Centisome position: 2.71

GC content: 37.57

Gene sequence:

>1251_bases
ATGGCAGCTTATCCCACACTCATAAGCTATGAGGAAGCATTAGAAATTTTGCAAAACCTCCCCATTAAACCCCTTGGCAC
ACAACAAGTGCATTTCAAAAATGCACTTCATAGAATCTGCGCACAAGATATATGCGCACCGCAGGATTATCCTGCTTATC
CTACTGCAGCAATGGACGGCTATGCAATCATTTTTGAAGACTTGCCCCTGCTCCTCTCTCAAGGTTTAAAAATCCTCCCA
CCAAATAAAGCAGGGAATCCTACACGTCCAACTCTTGAAAAAGGCTATGCAATCAAAACTTTTACCGGCTCTTTAATGCC
TATAAATGCCGATACACTTATCATTGTAGAGCATATCACACTTAAAAATAATAGAATCTTCCTCAATGTGCCTAAAGAAC
AAGTGTGTAAATCTCAATGGATTCGGCAAGTGGGTGATAATTATAAAAAAGGTGAAATCTTGTTGCGTAAAGGCGATAAA
ATCGGTGCTTTTGAAATTGGTTTGCTCGCTGAACTGAATTGTAATTTTATTCAAGTCTATCAAAAAGTGCGTGTAGGCGT
GATATGTGTAGGTGATGAGATTGTTGAAGTAGGTGCAATGAGTGAGCATACAAATATGGTCCGAAGTGTAAACACTCATC
TTTTAGAATCTTTACTTTTAGAAATGAATCAAGAGCCTATTATCTATCCTATTCTTAAAGATGATAAAGCGCTGATTAAA
GCTACTTATGAACAAGCGCTTAAAGAATGTGATGTGCTTCTTAGTGCTGGAGGTATGAGTATGGGGGATTACGATTACAC
CCAAGAAGTAATAAAAGAACTTACACAAATACAATTTAAAGGTGTGCGACTAAAGCCGGGCAAACCTGTAACTTGCGGTA
TATTTTGTAATGCTAATAAAACAACTTTTGTGCTTGGGTTGCCCGGATTCCCAAATTCGTGTGCAATAACTTTTCTACTT
TTTGGCTCCTTCATTCTTGCACGATTACAAAATAACATCTATAAACCCATAACACTTCAAGCAAAGCTCCTTGAAGATGT
ATATCGCACAGATTCTCGTATGGAATTTCGTGCCTGTGAGCTTATAAATGATAATGGCACACTTGGAGTTAAATTTAGCA
CTAAAAAATCCTTGCAAAGTTCAATGATTAATAATCTCACACATAATACTGCCCTCGCACTTCTTGCAGAAAATGGCAGT
AACTTACAAGCAGGAGAATCTATCCAAATAATGCTCTTAAATCAGTTTTAA

Upstream 100 bases:

>100_bases
AAGCAATCCCCATAATCAAGCATATTTGGAAGTCAAAAAACAAAAGCTTGGGCACTTGCTCTAATGCGTAGGGCAAGGAT
TGAAATTTAAAAGGAGAAAT

Downstream 100 bases:

>100_bases
CTTTAGCTTTGCTATGCTTTTTAGAATCTAAAAAAGGAGAGAGAGATGATTAGAGTTGATTTTTTAGGTCCAATGAGCGA
TATTCCCTCGCGCGAATTAG

Product: molybdopterin biosynthesis enzyme

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAAYPTLISYEEALEILQNLPIKPLGTQQVHFKNALHRICAQDICAPQDYPAYPTAAMDGYAIIFEDLPLLLSQGLKILP
PNKAGNPTRPTLEKGYAIKTFTGSLMPINADTLIIVEHITLKNNRIFLNVPKEQVCKSQWIRQVGDNYKKGEILLRKGDK
IGAFEIGLLAELNCNFIQVYQKVRVGVICVGDEIVEVGAMSEHTNMVRSVNTHLLESLLLEMNQEPIIYPILKDDKALIK
ATYEQALKECDVLLSAGGMSMGDYDYTQEVIKELTQIQFKGVRLKPGKPVTCGIFCNANKTTFVLGLPGFPNSCAITFLL
FGSFILARLQNNIYKPITLQAKLLEDVYRTDSRMEFRACELINDNGTLGVKFSTKKSLQSSMINNLTHNTALALLAENGS
NLQAGESIQIMLLNQF

Sequences:

>Translated_416_residues
MAAYPTLISYEEALEILQNLPIKPLGTQQVHFKNALHRICAQDICAPQDYPAYPTAAMDGYAIIFEDLPLLLSQGLKILP
PNKAGNPTRPTLEKGYAIKTFTGSLMPINADTLIIVEHITLKNNRIFLNVPKEQVCKSQWIRQVGDNYKKGEILLRKGDK
IGAFEIGLLAELNCNFIQVYQKVRVGVICVGDEIVEVGAMSEHTNMVRSVNTHLLESLLLEMNQEPIIYPILKDDKALIK
ATYEQALKECDVLLSAGGMSMGDYDYTQEVIKELTQIQFKGVRLKPGKPVTCGIFCNANKTTFVLGLPGFPNSCAITFLL
FGSFILARLQNNIYKPITLQAKLLEDVYRTDSRMEFRACELINDNGTLGVKFSTKKSLQSSMINNLTHNTALALLAENGS
NLQAGESIQIMLLNQF
>Mature_415_residues
AAYPTLISYEEALEILQNLPIKPLGTQQVHFKNALHRICAQDICAPQDYPAYPTAAMDGYAIIFEDLPLLLSQGLKILPP
NKAGNPTRPTLEKGYAIKTFTGSLMPINADTLIIVEHITLKNNRIFLNVPKEQVCKSQWIRQVGDNYKKGEILLRKGDKI
GAFEIGLLAELNCNFIQVYQKVRVGVICVGDEIVEVGAMSEHTNMVRSVNTHLLESLLLEMNQEPIIYPILKDDKALIKA
TYEQALKECDVLLSAGGMSMGDYDYTQEVIKELTQIQFKGVRLKPGKPVTCGIFCNANKTTFVLGLPGFPNSCAITFLLF
GSFILARLQNNIYKPITLQAKLLEDVYRTDSRMEFRACELINDNGTLGVKFSTKKSLQSSMINNLTHNTALALLAENGSN
LQAGESIQIMLLNQF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=438, Percent_Identity=27.6255707762557, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI66932975, Length=438, Percent_Identity=27.6255707762557, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787049, Length=369, Percent_Identity=28.1842818428184, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147659, Length=334, Percent_Identity=28.7425149700599, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562606, Length=332, Percent_Identity=27.4096385542169, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136978, Length=332, Percent_Identity=26.8072289156627, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24638841, Length=332, Percent_Identity=26.8072289156627, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46265; Mature: 46133

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYPTLISYEEALEILQNLPIKPLGTQQVHFKNALHRICAQDICAPQDYPAYPTAAMDG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAIIFEDLPLLLSQGLKILPPNKAGNPTRPTLEKGYAIKTFTGSLMPINADTLIIVEHIT
CEEEEHHHHHHHHCCCEEECCCCCCCCCCCCHHCCEEEEEECCCEEEECCCEEEEEEEEE
LKNNRIFLNVPKEQVCKSQWIRQVGDNYKKGEILLRKGDKIGAFEIGLLAELNCNFIQVY
EECCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHH
QKVRVGVICVGDEIVEVGAMSEHTNMVRSVNTHLLESLLLEMNQEPIIYPILKDDKALIK
HHHHEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
ATYEQALKECDVLLSAGGMSMGDYDYTQEVIKELTQIQFKGVRLKPGKPVTCGIFCNANK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCC
TTFVLGLPGFPNSCAITFLLFGSFILARLQNNIYKPITLQAKLLEDVYRTDSRMEFRACE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEE
LINDNGTLGVKFSTKKSLQSSMINNLTHNTALALLAENGSNLQAGESIQIMLLNQF
EECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
AAYPTLISYEEALEILQNLPIKPLGTQQVHFKNALHRICAQDICAPQDYPAYPTAAMDG
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAIIFEDLPLLLSQGLKILPPNKAGNPTRPTLEKGYAIKTFTGSLMPINADTLIIVEHIT
CEEEEHHHHHHHHCCCEEECCCCCCCCCCCCHHCCEEEEEECCCEEEECCCEEEEEEEEE
LKNNRIFLNVPKEQVCKSQWIRQVGDNYKKGEILLRKGDKIGAFEIGLLAELNCNFIQVY
EECCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHH
QKVRVGVICVGDEIVEVGAMSEHTNMVRSVNTHLLESLLLEMNQEPIIYPILKDDKALIK
HHHHEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
ATYEQALKECDVLLSAGGMSMGDYDYTQEVIKELTQIQFKGVRLKPGKPVTCGIFCNANK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCC
TTFVLGLPGFPNSCAITFLLFGSFILARLQNNIYKPITLQAKLLEDVYRTDSRMEFRACE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEE
LINDNGTLGVKFSTKKSLQSSMINNLTHNTALALLAENGSNLQAGESIQIMLLNQF
EECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]