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The map label for this gene is ribA

Identifier: 32265543

GI number: 32265543

Start: 48104

End: 48688

Strand: Direct

Name: ribA

Synonym: HH0044

Alternate gene names: 32265543

Gene position: 48104-48688 (Clockwise)

Preceding gene: 32265540

Following gene: 32265544

Centisome position: 2.67

GC content: 35.9

Gene sequence:

>585_bases
ATGAAATATGAAATATCAGAACAAGCCAAACTTCCTACGCGTTTTGGTAACTTTTTTACTAAAAGTTTTCGTGAATATGG
GAAAAATAACACTCTTTTTGAACATCTTGTAGTTTTTACACATACACTTGGAGAAACTCCTCTTGTAAGGATTCACTCTG
AATGTCTCACAGGCGATGTTTTTGGTTCAAAAAAATGTGATTGTGGTAATGAACTTGCCTTAGCAATGGAACAAATTGCG
CACAATACCGAAGGTGGAATGCTTATTTATTTGCGTCAAGAAGGACGTGGTATTGGATTATTTAATAAAATTAATGCTTA
TGCCCTGCAAGATAAAGGCTATGACACAGTGGAGGCAAATCAACAACTCGGATTTGCAGGTGATATGCGTAGTTACGAAA
TTGTGGGAGAAATTTTTAAACATTTTCATATTACACACATCAATCTTCTTACAAATAATCCGCGTAAAATAGACGCATTA
GCACCTTATGCAAAAGTTGTGCGTCATAGCATTATCACGCCAAGCAATCCCCATAATCAAGCATATTTGGAAGTCAAAAA
ACAAAAGCTTGGGCACTTGCTCTAA

Upstream 100 bases:

>100_bases
TATTAATTAATAAAAATTAATAAAATAAATTAAGATTTAACAAATTATTTTACAATGTGCTTCACAAAAACTCTCTGCTA
TATTATCAAAAGGAAAGATA

Downstream 100 bases:

>100_bases
TGCGTAGGGCAAGGATTGAAATTTAAAAGGAGAAATATGGCAGCTTATCCCACACTCATAAGCTATGAGGAAGCATTAGA
AATTTTGCAAAACCTCCCCA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVFTHTLGETPLVRIHSECLTGDVFGSKKCDCGNELALAMEQIA
HNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVEANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDAL
APYAKVVRHSIITPSNPHNQAYLEVKKQKLGHLL

Sequences:

>Translated_194_residues
MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVFTHTLGETPLVRIHSECLTGDVFGSKKCDCGNELALAMEQIA
HNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVEANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDAL
APYAKVVRHSIITPSNPHNQAYLEVKKQKLGHLL
>Mature_194_residues
MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVFTHTLGETPLVRIHSECLTGDVFGSKKCDCGNELALAMEQIA
HNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVEANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDAL
APYAKVVRHSIITPSNPHNQAYLEVKKQKLGHLL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=198, Percent_Identity=48.4848484848485, Blast_Score=177, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=42.0118343195266, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_HELHP (Q7VK48)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859575.1
- ProteinModelPortal:   Q7VK48
- SMR:   Q7VK48
- GeneID:   1493800
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0044
- NMPDR:   fig|235279.1.peg.44
- HOGENOM:   HBG735778
- OMA:   MVIYLRQ
- ProtClustDB:   PRK00393
- BioCyc:   HHEP235279:HH_0044-MONOMER
- BRENDA:   3.5.4.25
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 21997; Mature: 21997

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVFTHTLGETPLVRIHSECLTGDV
CCCCCCCHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHCCCC
FGSKKCDCGNELALAMEQIAHNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVEAN
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCCC
QQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDALAPYAKVVRHSIITPSNPHNQ
CCCCCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCEEHHHHHHHHHHHHHCCCCCCCCCH
AYLEVKKQKLGHLL
HHHHHHHHHHCCCC
>Mature Secondary Structure
MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVFTHTLGETPLVRIHSECLTGDV
CCCCCCCHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHCCCC
FGSKKCDCGNELALAMEQIAHNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVEAN
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCCC
QQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDALAPYAKVVRHSIITPSNPHNQ
CCCCCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCEEHHHHHHHHHHHHHCCCCCCCCCH
AYLEVKKQKLGHLL
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954