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The map label for this gene is uvrC

Identifier: 32265518

GI number: 32265518

Start: 18792

End: 20657

Strand: Direct

Name: uvrC

Synonym: HH0019

Alternate gene names: 32265518

Gene position: 18792-20657 (Clockwise)

Preceding gene: 32265517

Following gene: 32265519

Centisome position: 1.04

GC content: 34.62

Gene sequence:

>1866_bases
ATGAGCAATAAAGAATCTACAAGTTATAATCTCCTTGTGCATTTAGCAGATTTACCAACACAATCTGGCATTTATCAATT
TTTTGATAATGAAGATACTTTACTCTATGTAGGCAAAGCAAAGAATCTAAAAAACCGCATTAAAAGCTACTTGAGTATTG
AAAACAAACATATTGTGCCAAAAAATAATCTTAGTCCAAGAATCGCTCTTATGGTATCTCAAATCACTCGTATCCATACA
CTTTTAACAAATAATGAACAAGATGCGCTTATCCTTGAAAATTCTCTTATCAAAAGCCTCAAACCAAAATATAATATCCT
TTTGCGCGATGATAAAACTTATCCTTATATTTACATTGATAAATCCCTTCCCTATCCTCGCTTTGAGCTCACTCGCCAAG
TGCTCAAATCAAATCAGATTCAATATTTTGGACCTTTTGTAAGCGGAGCAAGGGAATTACTTGATAGCCTCTATGATAAT
CTACCACTTGTGCAGAAAAAATCCTGTGTCAAAGGCAAAAAAGCGTGTATTTTTCATCAGATTCACAAATGTCCTGCACC
TTGTGAGAATAAAGTTTCCATACAGACTTATGCCCAAACTATTGCACAAGGTATTGCACTTATTGAAGACAAAAAAGCCT
TATTAAAAATACTAGAATCTAAAATGCATACCCTCTCTCATAATCTGCAATTTGAAGAAGCTGCTATAATGCGTGATAGA
ATCCAAAAAATTACACAAATGAAAAACCAATCTATTATTGATATGATGAGCGGAGATTATGATGTATTTGTATTACAAGA
ACAAGATTGTGGCAAAAACTCGCAAGATTCTCACAAAAAATCTCATACTGCGTTGCATACGCATATTTTAATGATGCTTT
TTATCCGCAATGGACGCATTATTTCAAGTGATTTTATCCTTTTACACGATGATATACAATCCCATAATCTTCCACAACTC
TACACCCAAGCTTTACTTAACCATTATAAAACTCAAATACCACTCTTACCTCAAGAGATTCTCATTCCTCCATTTGACTT
TCCTGACTTACTGCATTTACAACAACTCTTAAGAGAGCAAACGCGCAGTTCTCTCAAAATCGTCCAACCACAAAGAGGTG
CAAAAAAAGACTTGCTACAACTCGCACATAAAAATGCTCTTGAAATAAGACGATTACATACACAGCAAAACAATACATTC
TCTACACTTGTAAGCATTAAAGAGTTGTGTGTATTAAGCCAAATACCTTATTCTATTGAGGTTTTTGATACCTCTCATCA
TAGCGGAACACACAATGTGGGCGGTATGATTGTGTATGAAAATGATGATTTTATTCGTTCTAAATATCGGCGATATGAGC
TTCACACAAGTGATGAATACAGCCAAATGCACGAAATGCTTTTACGCCGAGCTCAAAGTTTTGATTCTAATCCACCACCT
GCCTTATGGCTACTTGATGGAGGCAGGGCACAAATTAATCTAGCTCTTGATATTTTAAAAAGCGTAGGGGCAAATGTTGA
AGTCCTAGCAATTGCTAAAATGAAACATAATGCCAAAGCTTATCGTGCAAAAGGTAATGCTTTTGATATTTTGCGAAGCA
AAAATGCAGAGTTTAAACTAAAACCAAACGATAAAAGACTACAATTCCTCCAAAAACTCCGTGATGAAGTGCATCGTTAT
GCTATCACTTATCACCGCTATAAAAAACAAAAAGATATACAAAAGGCACAAATGATGGGAAAAAATTATACTCAAGCACA
AATTAAAAAACTTTTAGATTACTTTGGTAGCTTTGAATCTCTTAAAACTGCTTCACAAGAGCAAATTAATAGCGTGCTTT
CGCGCAGAAATCGTTCAGATACTTAA

Upstream 100 bases:

>100_bases
CATTCTAACGGAGATTTTGAAAATCTTGCAACAAATACCGCAATTTATGAAAAAATTGAATCCTTGCGTTTAGGTATTAA
GCGCCAATGGGACGCACAAA

Downstream 100 bases:

>100_bases
AAAGAGTGAAGAGAGTGAAGTATGAATAATACTAATCCCTTAAATGCAGTATATGATGAGGCTCTCTATATTTTACAAGA
GAGCTTTGATACTCATACGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MSNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVPKNNLSPRIALMVSQITRIHT
LLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYIDKSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDN
LPLVQKKSCVKGKKACIFHQIHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDR
IQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRIISSDFILLHDDIQSHNLPQL
YTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQTRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTF
STLVSIKELCVLSQIPYSIEVFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPP
ALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKLKPNDKRLQFLQKLRDEVHRY
AITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFESLKTASQEQINSVLSRRNRSDT

Sequences:

>Translated_621_residues
MSNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVPKNNLSPRIALMVSQITRIHT
LLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYIDKSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDN
LPLVQKKSCVKGKKACIFHQIHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDR
IQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRIISSDFILLHDDIQSHNLPQL
YTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQTRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTF
STLVSIKELCVLSQIPYSIEVFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPP
ALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKLKPNDKRLQFLQKLRDEVHRY
AITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFESLKTASQEQINSVLSRRNRSDT
>Mature_620_residues
SNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVPKNNLSPRIALMVSQITRIHTL
LTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYIDKSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDNL
PLVQKKSCVKGKKACIFHQIHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDRI
QKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRIISSDFILLHDDIQSHNLPQLY
TQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQTRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTFS
TLVSIKELCVLSQIPYSIEVFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPPA
LWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKLKPNDKRLQFLQKLRDEVHRYA
ITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFESLKTASQEQINSVLSRRNRSDT

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=637, Percent_Identity=29.5133437990581, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788037, Length=204, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_HELHP (Q7VK73)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859550.1
- ProteinModelPortal:   Q7VK73
- GeneID:   1493174
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0019
- NMPDR:   fig|235279.1.peg.19
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   HHEP235279:HH_0019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71814; Mature: 71683

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVP
CCCCCCCCEEEEEEEECCCCCCCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC
KNNLSPRIALMVSQITRIHTLLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYID
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCEEEEEECCCCCCEEEEE
KSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDNLPLVQKKSCVKGKKACIFHQ
CCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHH
IHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRI
HHHHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEE
ISSDFILLHDDIQSHNLPQLYTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQ
EECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
TRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTFSTLVSIKELCVLSQIPYSIE
HHCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
VFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPP
EEECCCCCCCCCCCCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCC
ALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKL
EEEEEECCCEEEHHHHHHHHHCCCCEEEEEEEHHHCCCHHHHCCCCHHHHHHCCCCCEEE
KPNDKRLQFLQKLRDEVHRYAITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFES
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHH
LKTASQEQINSVLSRRNRSDT
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVP
CCCCCCCEEEEEEEECCCCCCCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC
KNNLSPRIALMVSQITRIHTLLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYID
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCEEEEEECCCCCCEEEEE
KSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDNLPLVQKKSCVKGKKACIFHQ
CCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHH
IHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRI
HHHHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEE
ISSDFILLHDDIQSHNLPQLYTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQ
EECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
TRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTFSTLVSIKELCVLSQIPYSIE
HHCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
VFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPP
EEECCCCCCCCCCCCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCC
ALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKL
EEEEEECCCEEEHHHHHHHHHCCCCEEEEEEEHHHCCCHHHHCCCCHHHHHHCCCCCEEE
KPNDKRLQFLQKLRDEVHRYAITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFES
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHH
LKTASQEQINSVLSRRNRSDT
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954