Click here to switch to the map view.

The map label for this gene is trpC

Identifier: 32265501

GI number: 32265501

Start: 2484

End: 3989

Strand: Direct

Name: trpC

Synonym: HH0002

Alternate gene names: 32265501

Gene position: 2484-3989 (Clockwise)

Preceding gene: 32265500

Following gene: 32265502

Centisome position: 0.14

GC content: 37.05

Gene sequence:

>1506_bases
ATGGTAGAAGTTTTAGCCAAAATCACAACTCAACGCTCACAAGATATTACCCTTAAAGGCTTTGATTTTGGCTATGAGAT
TCCAAAGCAAAGAATCCACCCTTTAATCAAACCTCATTTAGATTCTGTCTTTTTTATTGCCGAAATAAAACGCTCTTCAC
CATCAGCTGGAACTATTAAGGAGATACCCTCTGTTACAAAACTTGCTGGGGATTATCTTAATGGCGGTGTTGGAGCAATT
TCGGTGCTTTGTGAGGAACACTATTTTGGAGGAAGCTTACTTGATTTAATGTCCGTAAAATCTGCTTATCCTAATGCCTG
TATCCTGCGCAAAGACTTTATTCAATATCCTCAAGAGGTTGATGTTAGTTATCGTGCTGGAGCAGATATGGTGCTGCTAA
TTGTAGCGATGTTTATCAATGAAGATGGGGGATTTTCTCATTTTAAAATGATTTATGAGGAATGTTTAAAAGTTGGAATT
ACACCACTTATTGAAGTGCATACTCAAGCTGAAATTGACTTTATTGCACCACTTCAAGCACCACTTATAGGCATTAATTC
GCGCAGTCTTCACACCTTTGAGATTAATATTCCTGCAGCCTGTGCGCTTAAAAATGCACTTTCTCATAGTAAAATCATCT
TTGAATCCGGTATAGATTCTCCTTACTCTGCTTTTATAATAGGCTCTTTAGACTTTGATGGACTACTTTGCGGAAGTTAT
CTTGTCTCACATAAAAATCCAACTACTGCTTTGCAATCTCTCAAACACGCTTTCACACTTGGCAAAACACAAAAACCTCG
CTTTTATCGCCAAATATTTGAATCCCTAAGTGCGCACTCCCCACAATCTAAACCTCTACTTAAAATATGTGGCATTACAA
ATCTTGATGATGCACTTATGGTAGGGCAAGAAAAAATAGATATGCTCGGTTTTATTCTTGTTAAACACAGCCCACGATAC
ATAGAATCTAAGCAGATTAAAGACATTGCTAAAGCCTTGCAAAAACTCTATCCACATATTTTACGCATAGCCGTAATAAA
TGATGATAAACAAGCACTCAATGAGGCAAAATCTCTTTATCAGCAAGGCTACATTGATGCAATTCAACTTCACGCATTGA
ATCCCCTCACACCTGATATATTTGCTAAGAGCGACCTTAAAGAGGCACTTTTTTGTTTTTATCCTGTGCAAAATATTGCT
CACATAGAGGATTTTACACCATATTATGAGGGTATATTTTGTCTTGTAGATTCCAAAAGTGCGCAAGGGGGTGGTTCTGG
GCAAAGTATCAATAAAGATGTTTTGCGCTCGTTACAGGAGAGATACTTGTGTATCGCAGGAGGAATCAATCCACACAATA
TTGCAGATTTTTTAGCTCTTAAGCCCACTTTGCTTGATATTAATTCTGGTATAGAAAAAGAAGTAGGAAAAAAAGATATT
CACAAACTCCGTGCTTTACTTGACAATCTAAAAAATGCAATAAAATCCACAAAGGAGCAAAAATGA

Upstream 100 bases:

>100_bases
AAGTTATTCAGGCACAATCAATCTCTCATATTATTTCTAGGTGATTACCTCAAATATGTTACAATCGCTTCTTTCACAAT
ACAGCAAAGGATAATAATAT

Downstream 100 bases:

>100_bases
AAAAAATACTTGTAACCTTAATTTTTAGCCTATGGAGCATTTGTGTTTTTGCAACTGCTAAAGAGCTTAATCTCATTATG
GCGGGCGATGCCCTGCTTCA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: IGPS 1 [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MVEVLAKITTQRSQDITLKGFDFGYEIPKQRIHPLIKPHLDSVFFIAEIKRSSPSAGTIKEIPSVTKLAGDYLNGGVGAI
SVLCEEHYFGGSLLDLMSVKSAYPNACILRKDFIQYPQEVDVSYRAGADMVLLIVAMFINEDGGFSHFKMIYEECLKVGI
TPLIEVHTQAEIDFIAPLQAPLIGINSRSLHTFEINIPAACALKNALSHSKIIFESGIDSPYSAFIIGSLDFDGLLCGSY
LVSHKNPTTALQSLKHAFTLGKTQKPRFYRQIFESLSAHSPQSKPLLKICGITNLDDALMVGQEKIDMLGFILVKHSPRY
IESKQIKDIAKALQKLYPHILRIAVINDDKQALNEAKSLYQQGYIDAIQLHALNPLTPDIFAKSDLKEALFCFYPVQNIA
HIEDFTPYYEGIFCLVDSKSAQGGGSGQSINKDVLRSLQERYLCIAGGINPHNIADFLALKPTLLDINSGIEKEVGKKDI
HKLRALLDNLKNAIKSTKEQK

Sequences:

>Translated_501_residues
MVEVLAKITTQRSQDITLKGFDFGYEIPKQRIHPLIKPHLDSVFFIAEIKRSSPSAGTIKEIPSVTKLAGDYLNGGVGAI
SVLCEEHYFGGSLLDLMSVKSAYPNACILRKDFIQYPQEVDVSYRAGADMVLLIVAMFINEDGGFSHFKMIYEECLKVGI
TPLIEVHTQAEIDFIAPLQAPLIGINSRSLHTFEINIPAACALKNALSHSKIIFESGIDSPYSAFIIGSLDFDGLLCGSY
LVSHKNPTTALQSLKHAFTLGKTQKPRFYRQIFESLSAHSPQSKPLLKICGITNLDDALMVGQEKIDMLGFILVKHSPRY
IESKQIKDIAKALQKLYPHILRIAVINDDKQALNEAKSLYQQGYIDAIQLHALNPLTPDIFAKSDLKEALFCFYPVQNIA
HIEDFTPYYEGIFCLVDSKSAQGGGSGQSINKDVLRSLQERYLCIAGGINPHNIADFLALKPTLLDINSGIEKEVGKKDI
HKLRALLDNLKNAIKSTKEQK
>Mature_501_residues
MVEVLAKITTQRSQDITLKGFDFGYEIPKQRIHPLIKPHLDSVFFIAEIKRSSPSAGTIKEIPSVTKLAGDYLNGGVGAI
SVLCEEHYFGGSLLDLMSVKSAYPNACILRKDFIQYPQEVDVSYRAGADMVLLIVAMFINEDGGFSHFKMIYEECLKVGI
TPLIEVHTQAEIDFIAPLQAPLIGINSRSLHTFEINIPAACALKNALSHSKIIFESGIDSPYSAFIIGSLDFDGLLCGSY
LVSHKNPTTALQSLKHAFTLGKTQKPRFYRQIFESLSAHSPQSKPLLKICGITNLDDALMVGQEKIDMLGFILVKHSPRY
IESKQIKDIAKALQKLYPHILRIAVINDDKQALNEAKSLYQQGYIDAIQLHALNPLTPDIFAKSDLKEALFCFYPVQNIA
HIEDFTPYYEGIFCLVDSKSAQGGGSGQSINKDVLRSLQERYLCIAGGINPHNIADFLALKPTLLDINSGIEKEVGKKDI
HKLRALLDNLKNAIKSTKEQK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=499, Percent_Identity=26.25250501002, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322638, Length=230, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 55554; Mature: 55554

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVLAKITTQRSQDITLKGFDFGYEIPKQRIHPLIKPHLDSVFFIAEIKRSSPSAGTIK
CHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHCHHHHHHHCCEEEEEEHHCCCCCCCCHH
EIPSVTKLAGDYLNGGVGAISVLCEEHYFGGSLLDLMSVKSAYPNACILRKDFIQYPQEV
HCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCCC
DVSYRAGADMVLLIVAMFINEDGGFSHFKMIYEECLKVGITPLIEVHTQAEIDFIAPLQA
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEECCCCCEEEECCCCC
PLIGINSRSLHTFEINIPAACALKNALSHSKIIFESGIDSPYSAFIIGSLDFDGLLCGSY
CEEECCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCHHHHHHH
LVSHKNPTTALQSLKHAFTLGKTQKPRFYRQIFESLSAHSPQSKPLLKICGITNLDDALM
HHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHH
VGQEKIDMLGFILVKHSPRYIESKQIKDIAKALQKLYPHILRIAVINDDKQALNEAKSLY
HCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHH
QQGYIDAIQLHALNPLTPDIFAKSDLKEALFCFYPVQNIAHIEDFTPYYEGIFCLVDSKS
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCC
AQGGGSGQSINKDVLRSLQERYLCIAGGINPHNIADFLALKPTLLDINSGIEKEVGKKDI
CCCCCCCCCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHCCCCEEECCCCHHHHCCHHHH
HKLRALLDNLKNAIKSTKEQK
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVEVLAKITTQRSQDITLKGFDFGYEIPKQRIHPLIKPHLDSVFFIAEIKRSSPSAGTIK
CHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHCHHHHHHHCCEEEEEEHHCCCCCCCCHH
EIPSVTKLAGDYLNGGVGAISVLCEEHYFGGSLLDLMSVKSAYPNACILRKDFIQYPQEV
HCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCCC
DVSYRAGADMVLLIVAMFINEDGGFSHFKMIYEECLKVGITPLIEVHTQAEIDFIAPLQA
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEECCCCCEEEECCCCC
PLIGINSRSLHTFEINIPAACALKNALSHSKIIFESGIDSPYSAFIIGSLDFDGLLCGSY
CEEECCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCHHHHHHH
LVSHKNPTTALQSLKHAFTLGKTQKPRFYRQIFESLSAHSPQSKPLLKICGITNLDDALM
HHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHH
VGQEKIDMLGFILVKHSPRYIESKQIKDIAKALQKLYPHILRIAVINDDKQALNEAKSLY
HCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHH
QQGYIDAIQLHALNPLTPDIFAKSDLKEALFCFYPVQNIAHIEDFTPYYEGIFCLVDSKS
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCC
AQGGGSGQSINKDVLRSLQERYLCIAGGINPHNIADFLALKPTLLDINSGIEKEVGKKDI
CCCCCCCCCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHCCCCEEECCCCHHHHCCHHHH
HKLRALLDNLKNAIKSTKEQK
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361288; 12000953 [H]