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The map label for this gene is cycA

Identifier: 30065499

GI number: 30065499

Start: 4448896

End: 4450308

Strand: Reverse

Name: cycA

Synonym: S4543

Alternate gene names: 30065499

Gene position: 4450308-4448896 (Counterclockwise)

Preceding gene: 30065501

Following gene: 30065495

Centisome position: 96.76

GC content: 52.8

Gene sequence:

>1413_bases
ATGGTAGATCAGGTAAAAGTCGTTGCCGATGATCAGGCTCCGGCTGAACAGTCGCTACGGCGCAATCTCACAAACCGACA
TGTTCAGCTTATTGCCATTGGAGGTGCCATTGGTACTGGGTTGTTTATGGGGTCCGGCAAAACGATTAGCCTTGCCGGGC
CGTCGATCATTTTCGTTTATATGATCATTGGTTTTATGCTCTTTTTCGTGATGCGGGCAATGGGGGAATTGCTGCTTTCG
AATCTGGAATACAAATCTTTTAGTGACTTCGCTTCCGATTTACTGGGGCCGTGGGCGGGATATTTCACCGGCTGGACTTA
CTGGTTCTGCTGGGTTGTAACCGGTATGGCAGACGTGGTGGCGATCACGGCTTATGCTCAGTTCTGGTTCCCCGATCTCT
CCGACTGGGTCGCCTCGCTGGCGGTGATAGTGCTGCTGCTGACGCTCAACCTTGCCACCGTGAAAATGTTCGGTGAGATG
GAGTTCTGGTTTGCGATGATCAAAATCGTCGCCATCGTGTCGCTGATTGTCGTCGGCCTGGTCATGGTGGCGATGCACTT
TCAGTCACCGACCGGTGTGGAAGCGTCATTCGCGCATTTGTGGAATGACGGCGGCTGGTTCCCGAAAGGTTTAAGTGGCT
TCTTTGCCGGATTCCAGATAGCGGTTTTCGCTTTCGTGGGGATTGAGCTGGTAGGTACAACAGCTGCGGAAACCAAAGAT
CCGGAGAAATCACTGCCACGCGCGATTAACTCCATTCCGATCCGTATCATTATGTTCTACGTCTTCGCGCTGATTGTGAT
TATGTCCGTGACACCGTGGAGTTCGGTAGTCCCGGAGAAAAGCCCGTTCGTTGAGCTGTTTGTGTTGGTAGGTTTGCCTG
CGGCTGCCAGCGTGATCAACTTTGTGGTGCTGACCTCTGCGGCGTCTTCCGCTAACAGCGGTGTCTTCTCTACCAGCCGT
ATGCTGTTTGGTCTGGCGCAGGAAGGTGTTGCGCCGAAAGCGTTCGCTAAACTTTCTAAGCGCGCAGTACCCGCGAAAGG
GTTGACCTTCTCGTGTATCTGTCTGCTCGGCGGCGTGGTGATGTTGTATGTGAATCCTAGCGTGATTGGCGCGTTCACGA
TGATTACAACCGTTTCCGCGATTCTGTTTATGTTCGTCTGGACGATTATCCTTTGCTCTTACCTGGTGTACCGCAAACAG
CGTCCTCATCTGCATGAAAAGTCGATCTACAAGATGCCGCTCGGCAAGCTGATGTGCTGGGTATGTATGGCGTTCTTTGT
GTTCGTGGTCGTGTTGCTGACACTGGAAGATGACACTCGCCAGGCGCTGCTGGTTACCCCGCTGTGGTTTATCGCGCTGG
GGTTGGGCTGGCTGTTTATTGGTAAGAAGCGGGCTGCTGAACTGCGGAAATAA

Upstream 100 bases:

>100_bases
TTACCTAATATCGATGAGTCCCGATACAGATTCGTCGTATCATAGACTGACTAAAGGCCGTAGAGCCTGAACAACACAGA
CAGGTACAGGAAGAAAAAAC

Downstream 100 bases:

>100_bases
CCGCATTATCATGCTGGATGGCGCAATGCCATCCAGCTTTTAGATCACTCACCCGCTAGGGCGCGTGGGAACAGTACATT
GTTTTCCAGACTGATGTGAT

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHVQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK

Sequences:

>Translated_470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHVQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
>Mature_470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHVQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=22.0708446866485, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI181337167, Length=343, Percent_Identity=22.1574344023324, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI114326544, Length=363, Percent_Identity=22.038567493113, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI114326550, Length=363, Percent_Identity=22.038567493113, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI258645169, Length=145, Percent_Identity=29.6551724137931, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648063, Length=369, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648022, Length=369, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=470, Percent_Identity=99.7872340425532, Blast_Score=943, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=461, Percent_Identity=40.1301518438178, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=37.7483443708609, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=40.9691629955947, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=38.3116883116883, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=37.4727668845316, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=32.9032258064516, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788480, Length=422, Percent_Identity=35.0710900473934, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=30.2013422818792, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI2367353, Length=399, Percent_Identity=24.5614035087719, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI87082023, Length=400, Percent_Identity=21.5, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=365, Percent_Identity=24.1095890410959, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=448, Percent_Identity=21.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=374, Percent_Identity=25.9358288770053, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=461, Percent_Identity=31.8872017353579, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.4553990610329, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=28.9237668161435, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=29.6912114014252, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=414, Percent_Identity=30.1932367149758, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=28.5403050108932, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=28.0701754385965, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=430, Percent_Identity=27.6744186046512, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=25.8454106280193, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=26.2254901960784, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=437, Percent_Identity=27.0022883295195, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=27.1144278606965, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=26.5853658536585, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=417, Percent_Identity=26.8585131894484, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=26, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=28.9099526066351, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=419, Percent_Identity=27.4463007159904, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=489, Percent_Identity=23.9263803680982, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=21.2290502793296, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=21.2290502793296, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45550968, Length=419, Percent_Identity=26.0143198090692, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921172, Length=419, Percent_Identity=26.0143198090692, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51646; Mature: 51646

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVVADDQAPAEQSLRRNLTNRHVQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MVDQVKVVADDQAPAEQSLRRNLTNRHVQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]