Click here to switch to the map view.

The map label for this gene is cysQ

Identifier: 30065493

GI number: 30065493

Start: 4442679

End: 4443419

Strand: Reverse

Name: cysQ

Synonym: S4537

Alternate gene names: 30065493

Gene position: 4443419-4442679 (Counterclockwise)

Preceding gene: 30065495

Following gene: 30065491

Centisome position: 96.61

GC content: 55.47

Gene sequence:

>741_bases
ATGTTAGATCAAGTATGCCAGCTTGCACGGAATGCAGGCGATGCCATTATGCAGGTCTACGACGGGACGAAACCGATGGA
CGTCGTCAGCAAAGCGGACAATTCTCCGGTAACGGCAGCGGATATTGCCGCTCACACCGTTATCATGGACGGTTTACGTA
CGCTGGCACCGGATATTCCGGTCCTTTCTGAAGAAGATCCTCCCGGTTGGGAAGTCCGTCAGCACTGGCAGCGTTACTGG
CTGGTAGACCCGCTGGATGGTACTAAAGAGTTTATTAAACGTAATGGCGAATTCACCGTTAACATTGCGCTCATTGACCA
TGGCAAACCGATTTTAGGTGTGGTGTATGCGCCGGTAATGAACGTAATGTACAGCGCGGCAGAAGGCAAGGCCTGGAAAG
AAGAGTGCGGTGTGCGCAAGCTGATTCAGGTCCGCGATGCGCGCCCGCCGCTGGTGGTTATCAGCCGTTCCCATGCAGAT
GCGGAGCTGAAAGAGTATCTGCAACAGCTTGGCGAACATCAGACCACGTCCATCGGCTCTTCGCTGAAATTCTGCCTGGT
GGCGGAAGGACAGGCGCAGCTGTACCCGCGCTTCGGACCAACGAATATTTGGGACACCGCCGCCGGACATGCTGTGGCTG
CAGCTGCCGGAGCGCACGTTCACGACTGGCAGGGTAAACCGCTGGATTACACTCCGCGCGAGTCGTTCCTGAATCCGGGG
TTCAGAGTGTCCATTTACTAA

Upstream 100 bases:

>100_bases
GCTTTGAAAATGATGACACTATCACAGTTGGCGCATTCATTAACGATAGGGTATAAGTAAAACAATAAGTTAACACCGCT
CACAGAGACGAGGTGGAGAA

Downstream 100 bases:

>100_bases
ATTCAGATGGCAGAAACAGTGTATTTCCTGATTCTGCCATCCTGATTTATCCCAACCTAAAAAGTTATAAATAAAAAGAG
ATTGTATTTAAAGTGCAAAA

Product: adenosine-3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLAPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKLIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY

Sequences:

>Translated_246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLAPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKLIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY
>Mature_246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLAPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKLIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031789, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790659, Length=246, Percent_Identity=98.780487804878, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1788882, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71995897, Length=265, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995905, Length=265, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=229, Percent_Identity=25.3275109170306, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641722, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357303, Length=162, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664926, Length=235, Percent_Identity=24.2553191489362, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27145; Mature: 27145

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLAPDIP
CHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKLIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC
>Mature Secondary Structure
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLAPDIP
CHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKLIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]