| Definition | Shigella flexneri 2a str. 2457T, complete genome. |
|---|---|
| Accession | NC_004741 |
| Length | 4,599,354 |
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The map label for this gene is nikD
Identifier: 30065244
GI number: 30065244
Start: 4185700
End: 4186464
Strand: Reverse
Name: nikD
Synonym: S4266
Alternate gene names: 30065244
Gene position: 4186464-4185700 (Counterclockwise)
Preceding gene: 30065245
Following gene: 30065243
Centisome position: 91.02
GC content: 58.95
Gene sequence:
>765_bases ATGCCGCAACAGATTGAACTACGTAATATCACGCTACAGGCCGCGCAGCCGCTGGTACACGGTGTATCGTTAACCCTGCA ACGCGGGCGCGTGCTGGCGTTAGTCGGCGGTAGCGGCAGCGGGAAATCATTAACCTGCGCCGCGACGCTGGGCATTTTGC CCGCTGGCGTTCGCCAGACGGCGGGGGAAATTTTAGCCGATGGCAAACCGGTTTCGCCTTACGCCCTGCGCGGCATCAAA ATTGCCACCATCATGCAGAACCCGCGCAGCGCCTTTAATCCACTGCACACCATGCACACCCACGCGCGGGAAACCTGCCT GGCGTTAGGGAAACCCGCCGATGACGCTACGCTTACCGCTGCCATAGAAGCGGTGGGGCTGGAAAACGCCGCGCGCGTGC TGAAGCTGTACCCGTTCGAGATGAGCGGCGGCATGTTGCAGCGCATGATGATTGCGATGGCGGTGCTGTGTGAATCACCG TTTATCATCGCCGATGAACCGACCACCGACCTCGACGTGGTAGCACAGGCGCGCATCCTCGATCTGCTGGAAAGCATTAT GCAAAAACAAGCGCCGGGAATGCTGCTGGTCACCCATGATATGGGCGTTGTGGCGCGTCTGGCGGATGACGTGGCGGTGA TGTCACAAGGTAAAATTGTCGAACAGGGCGATGTAGAAACGCTGTTTAACGCCCCCAAACATACGGTGACGCGCAGCCTG GTTTCCGCTCATCTCGCTCTCTACGGTATGGAGCTGGCATCATGA
Upstream 100 bases:
>100_bases CGGGGCTGGCGCTGTTTATCAGCGTGATGGCCTTTAACCTGGTGGGTGACGCACTGCGCGATCATCTGGATCCTCATCTG GTGACGGAGCACGCACACTA
Downstream 100 bases:
>100_bases CCTTACTTAACGTCTGCGGCCTTTCCCATCACTATGCCCACGGTGGATTTAGCGGAAAACATCAACATCAGGCGGTGCTG AATAACGTTTCCCTGACCCT
Product: nickel transporter ATP-binding protein NikD
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 254; Mature: 253
Protein sequence:
>254_residues MPQQIELRNITLQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQTAGEILADGKPVSPYALRGIK IATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTAAIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESP FIIADEPTTDLDVVAQARILDLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSQGKIVEQGDVETLFNAPKHTVTRSL VSAHLALYGMELAS
Sequences:
>Translated_254_residues MPQQIELRNITLQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQTAGEILADGKPVSPYALRGIK IATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTAAIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESP FIIADEPTTDLDVVAQARILDLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSQGKIVEQGDVETLFNAPKHTVTRSL VSAHLALYGMELAS >Mature_253_residues PQQIELRNITLQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQTAGEILADGKPVSPYALRGIKI ATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTAAIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESPF IIADEPTTDLDVVAQARILDLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSQGKIVEQGDVETLFNAPKHTVTRSLV SAHLALYGMELAS
Specific function: Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system [H]
COG id: COG0444
COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ABC transporter domain [H]
Homologues:
Organism=Homo sapiens, GI171184400, Length=262, Percent_Identity=29.0076335877863, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI27436953, Length=215, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI42490749, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI105990541, Length=211, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI153792144, Length=215, Percent_Identity=24.6511627906977, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI116734710, Length=202, Percent_Identity=25.7425742574257, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI21536376, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI27477115, Length=210, Percent_Identity=24.2857142857143, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1789890, Length=254, Percent_Identity=98.8188976377953, Blast_Score=504, Evalue=1e-144, Organism=Escherichia coli, GI1788506, Length=241, Percent_Identity=41.0788381742739, Blast_Score=163, Evalue=1e-41, Organism=Escherichia coli, GI145693107, Length=240, Percent_Identity=39.5833333333333, Blast_Score=160, Evalue=6e-41, Organism=Escherichia coli, GI1789963, Length=234, Percent_Identity=36.3247863247863, Blast_Score=148, Evalue=3e-37, Organism=Escherichia coli, GI1787759, Length=235, Percent_Identity=34.8936170212766, Blast_Score=139, Evalue=1e-34, Organism=Escherichia coli, GI48994883, Length=234, Percent_Identity=35.4700854700855, Blast_Score=137, Evalue=7e-34, Organism=Escherichia coli, GI1789962, Length=232, Percent_Identity=35.7758620689655, Blast_Score=125, Evalue=4e-30, Organism=Escherichia coli, GI1787500, Length=232, Percent_Identity=32.7586206896552, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1787547, Length=247, Percent_Identity=29.9595141700405, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1787548, Length=260, Percent_Identity=28.0769230769231, Blast_Score=108, Evalue=4e-25, Organism=Escherichia coli, GI1787758, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI1789891, Length=216, Percent_Identity=36.1111111111111, Blast_Score=104, Evalue=5e-24, Organism=Escherichia coli, GI48994997, Length=231, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=8e-22, Organism=Escherichia coli, GI1788225, Length=257, Percent_Identity=31.1284046692607, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI1786398, Length=256, Percent_Identity=30.078125, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1786345, Length=224, Percent_Identity=31.25, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1789032, Length=230, Percent_Identity=29.1304347826087, Blast_Score=85, Evalue=6e-18, Organism=Escherichia coli, GI1790162, Length=252, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1787112, Length=228, Percent_Identity=28.5087719298246, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI87081791, Length=236, Percent_Identity=31.3559322033898, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI87081834, Length=216, Percent_Identity=31.4814814814815, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI87081709, Length=231, Percent_Identity=26.8398268398268, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI1787029, Length=239, Percent_Identity=27.1966527196653, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI1788450, Length=252, Percent_Identity=27.3809523809524, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI1789672, Length=246, Percent_Identity=28.8617886178862, Blast_Score=78, Evalue=6e-16, Organism=Escherichia coli, GI1786803, Length=230, Percent_Identity=29.1304347826087, Blast_Score=77, Evalue=8e-16, Organism=Escherichia coli, GI1787143, Length=226, Percent_Identity=28.7610619469027, Blast_Score=77, Evalue=2e-15, Organism=Escherichia coli, GI1787089, Length=244, Percent_Identity=29.0983606557377, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI48994943, Length=229, Percent_Identity=26.6375545851528, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1790739, Length=220, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-15, Organism=Escherichia coli, GI1788761, Length=229, Percent_Identity=31.4410480349345, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789873, Length=208, Percent_Identity=29.3269230769231, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1787712, Length=254, Percent_Identity=27.9527559055118, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1787164, Length=193, Percent_Identity=33.160621761658, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1788540, Length=227, Percent_Identity=30.3964757709251, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1786872, Length=216, Percent_Identity=32.8703703703704, Blast_Score=71, Evalue=6e-14, Organism=Escherichia coli, GI1786703, Length=212, Percent_Identity=31.1320754716981, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1789586, Length=246, Percent_Identity=27.6422764227642, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1786253, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1790525, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1787370, Length=216, Percent_Identity=26.8518518518519, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1788165, Length=218, Percent_Identity=28.4403669724771, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1788644, Length=128, Percent_Identity=32.03125, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1786319, Length=218, Percent_Identity=25.2293577981651, Blast_Score=65, Evalue=5e-12, Organism=Escherichia coli, GI1787792, Length=229, Percent_Identity=31.0043668122271, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1786654, Length=265, Percent_Identity=27.5471698113208, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1789991, Length=218, Percent_Identity=26.605504587156, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1787105, Length=210, Percent_Identity=30, Blast_Score=61, Evalue=8e-11, Organism=Caenorhabditis elegans, GI193208177, Length=239, Percent_Identity=25.9414225941423, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI71983523, Length=221, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71983510, Length=221, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71983516, Length=221, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI115535101, Length=242, Percent_Identity=27.6859504132231, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71992285, Length=238, Percent_Identity=28.1512605042017, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17565938, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17510237, Length=230, Percent_Identity=28.695652173913, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI193211015, Length=231, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI193211017, Length=231, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI115533592, Length=241, Percent_Identity=27.3858921161826, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17567265, Length=240, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI212646699, Length=227, Percent_Identity=26.8722466960352, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193202349, Length=241, Percent_Identity=24.896265560166, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71984940, Length=240, Percent_Identity=26.25, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71996809, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17567269, Length=222, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322640, Length=224, Percent_Identity=28.125, Blast_Score=65, Evalue=9e-12, Organism=Drosophila melanogaster, GI28574533, Length=242, Percent_Identity=26.8595041322314, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI23397593, Length=237, Percent_Identity=28.6919831223629, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24643674, Length=208, Percent_Identity=23.5576923076923, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR015857 - InterPro: IPR003593 - InterPro: IPR014138 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: =3.6.3.24 [H]
Molecular weight: Translated: 26924; Mature: 26793
Theoretical pI: Translated: 6.63; Mature: 6.63
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 5.1 %Met (Translated Protein) 6.3 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 4.7 %Met (Mature Protein) 5.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPQQIELRNITLQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQT CCCCEEEHEEEHHHHHHHHHHHHEEEECCEEEEEECCCCCCCEEEEEEHHCCCCCCHHHH AGEILADGKPVSPYALRGIKIATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTA HHHHHCCCCCCCHHHHCCEEEEEEECCCHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHH AIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESPFIIADEPTTDLDVVAQARIL HHHHHCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH DLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSQGKIVEQGDVETLFNAPKHTVTRSL HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEECCCCHHHHHCCCHHHHHHHH VSAHLALYGMELAS HHHHHHHHHHHHCC >Mature Secondary Structure PQQIELRNITLQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQT CCCEEEHEEEHHHHHHHHHHHHEEEECCEEEEEECCCCCCCEEEEEEHHCCCCCCHHHH AGEILADGKPVSPYALRGIKIATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTA HHHHHCCCCCCCHHHHCCEEEEEEECCCHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHH AIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESPFIIADEPTTDLDVVAQARIL HHHHHCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH DLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSQGKIVEQGDVETLFNAPKHTVTRSL HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEECCCCHHHHHCCCHHHHHHHH VSAHLALYGMELAS HHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 7.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]