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The map label for this gene is aslA [H]

Identifier: 29348466

GI number: 29348466

Start: 3878142

End: 3879668

Strand: Reverse

Name: aslA [H]

Synonym: BT_3057

Alternate gene names: 29348466

Gene position: 3879668-3878142 (Counterclockwise)

Preceding gene: 29348467

Following gene: 29348459

Centisome position: 61.97

GC content: 47.61

Gene sequence:

>1527_bases
ATGAGAACAAAACGAGCTTTTAAGGAATTTTGTGTATTGGGTGGTTTGGCATCTTCCGTTTGCGGGGTGGCTCAGGAACG
CCCGAATATTATTGTCTTCCTTGTAGATGACATGGGACTTATGGATACGTCGGTTCCTTTTATCGCAGATGAGAGTGGTC
AGCCGGTGCGTCATCCGCTGAATGACTGGTATCATACTCCGAATATGGAGAGACTGGCTAAACAGGGTATTTGTTTCTCT
ACTTTTTACGCACAGAGCGTGAGTTCCCCTTCCAGAGCTTCCATCATGACCGGACAGAATGCGACCAGGCATGGAGTCAC
TAACTGGATTAATGCTGAGAGCAACAACCGGAATCCTTTCGGACCGCCCCAATGGAACTGGAAAGGTCTCAGAAAAGATA
TGCCTACCATGCCGAGAGTCCTGCAACAAGCCGGATATAAAACCATTCATGTAGGAAAAGCACATTTCGGCTGTATGGGA
AGCGAAGGAGAGAATCCGCTGAATATCGGCTTTGATGTAAATATCGCAGGTTCCGGCATTGGACATCCCGGCAGCTATTA
TGGCGAATGGGGATACGGGCATATCAAGGGACAGAAGATTAGAGCAGTTCCTGACCTGGAGAAATATCACGGTACAGATA
CCTTCCTGAGTGAAGCGCTGACTATAGAAGCGAATCGGGAGATCACCAAAGCCGTAGAAGAAAAACGACCTTTCTATCTG
AATATGGCCCATTACGCAGTTCATTCACCTTTCCAGGCAGACAAACGTTTCTTGTCACGCTACACCGACCCGGATAAGAA
CGAGCAGGCAAGAGCTTTTGCTACATTGATAGAAGGCATGGATAAATCATTAGGCGACATCATGGACCAACTCGAAAAGC
TGGGAATTGCCGAAAATACGCTGATTCTCTTTTTAGGAGATAACGGTGGTGATGCTCCATTGGGAGATGAACGTGGCTAT
GGTTCTTCCGCTCCGCTGAGAGGTAAAAAGGGGACGGAGTTTGAAGGTGGTATGCGTGTTCCTTTCATCGCAGCTTGGGC
CAAGCCTGAGAAGAAGAGCAAAGTACAGAAGAACTTGCCTATTGAAGTAGGAAGTATGCAGACACAGTTGGGCACAATCA
TGGATATCTATCCGACTGTTCTGTCTGTGGCAGGATGCGAAGTTCCCCAAAACTACGTGATAGACGGATTCGATCTGAAA
AAGCAACTGAGCGGTAAGGTGGACAAGAAGCGTCCCGAGTCTTTCCTGATGCACTTCCCTCACGCACACCGCGGCAGCTA
CTTCACCACCTATCGCATGGGCGACTGGAAACTGATTTATTATTATCTTCCCGAGACTCCGAAACAACCCAAAGCCTTGC
TTTACAATCTGAAAGACGATCCGGAAGAAAGGAATGAGCTGTCTGCCGCACATCCGGATCAATGCAGAGAGATGATTCGG
GAAATGTCCGCCCGGCTAGAAAAGGAAGGAGCTCTTTATCCGGTGGATAAACAAGGAAATGAGTTGAAGCCTTTTGTTTA
CTTTTAA

Upstream 100 bases:

>100_bases
CATGACAAGGCGGATACGGAAATTAAACTTTTTATTTCAGTAAATTTAAATCTATTGCGACACGTACAATAACTAGGATA
TAAATCATAAATACTATGTA

Downstream 100 bases:

>100_bases
ATAGGTGCTACTATTTCAACTGTCTGTTTTGCCAAAGCATATCTATTAGGCAAAACAGACAGAATTATATATCATTTGTC
AGATACAATTGCTATGACCG

Product: N-acetylgalactosamine-6-sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSVPFIADESGQPVRHPLNDWYHTPNMERLAKQGICFS
TFYAQSVSSPSRASIMTGQNATRHGVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMG
SEGENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTIEANREITKAVEEKRPFYL
NMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMDKSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGY
GSSAPLRGKKGTEFEGGMRVPFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDLK
KQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLKDDPEERNELSAAHPDQCREMIR
EMSARLEKEGALYPVDKQGNELKPFVYF

Sequences:

>Translated_508_residues
MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSVPFIADESGQPVRHPLNDWYHTPNMERLAKQGICFS
TFYAQSVSSPSRASIMTGQNATRHGVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMG
SEGENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTIEANREITKAVEEKRPFYL
NMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMDKSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGY
GSSAPLRGKKGTEFEGGMRVPFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDLK
KQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLKDDPEERNELSAAHPDQCREMIR
EMSARLEKEGALYPVDKQGNELKPFVYF
>Mature_508_residues
MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSVPFIADESGQPVRHPLNDWYHTPNMERLAKQGICFS
TFYAQSVSSPSRASIMTGQNATRHGVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMG
SEGENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTIEANREITKAVEEKRPFYL
NMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMDKSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGY
GSSAPLRGKKGTEFEGGMRVPFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDLK
KQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLKDDPEERNELSAAHPDQCREMIR
EMSARLEKEGALYPVDKQGNELKPFVYF

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=529, Percent_Identity=29.3005671077505, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI109389362, Length=509, Percent_Identity=26.5225933202358, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI59797060, Length=498, Percent_Identity=27.9116465863454, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI38569405, Length=519, Percent_Identity=25.626204238921, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI45430057, Length=498, Percent_Identity=26.7068273092369, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI38569407, Length=407, Percent_Identity=27.7641277641278, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI146229331, Length=484, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI146229329, Length=484, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI6005990, Length=484, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI146229324, Length=484, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI53831991, Length=304, Percent_Identity=26.9736842105263, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI146229327, Length=262, Percent_Identity=28.6259541984733, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI157266309, Length=300, Percent_Identity=29, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31742482, Length=308, Percent_Identity=28.8961038961039, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI58743319, Length=294, Percent_Identity=27.5510204081633, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI71852584, Length=303, Percent_Identity=25.7425742574257, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI71852586, Length=153, Percent_Identity=32.0261437908497, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790233, Length=519, Percent_Identity=24.0847784200385, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081924, Length=545, Percent_Identity=25.6880733944954, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI115533416, Length=491, Percent_Identity=25.050916496945, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI115533418, Length=452, Percent_Identity=25.6637168141593, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24666109, Length=440, Percent_Identity=27.9545454545455, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24666175, Length=417, Percent_Identity=29.0167865707434, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281366397, Length=445, Percent_Identity=26.7415730337079, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281366395, Length=445, Percent_Identity=26.7415730337079, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24666163, Length=445, Percent_Identity=26.7415730337079, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281363223, Length=431, Percent_Identity=29.0023201856148, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57010; Mature: 57010

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSVPFIADESGQPVRHPL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCH
NDWYHTPNMERLAKQGICFSTFYAQSVSSPSRASIMTGQNATRHGVTNWINAESNNRNPF
HHHHCCCCHHHHHHCCCEEEHHHHHHCCCCCCCEEECCCCCCCCCCCCEECCCCCCCCCC
GPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMGSEGENPLNIGFDVNIAGSGI
CCCCCCCHHHHCCCCHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCEEEEEEEEECCCCC
GHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTIEANREITKAVEEKRPFYL
CCCCCCCCCCCEEEECCCEEECCCCHHHHCCCHHHHHHHEEEECCHHHHHHHHHCCCEEE
NMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMDKSLGDIMDQLEKLGIAENT
EEHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LILFLGDNGGDAPLGDERGYGSSAPLRGKKGTEFEGGMRVPFIAAWAKPEKKSKVQKNLP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCC
IEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDLKKQLSGKVDKKRPESFLMHFP
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCCCCCCCCHHHHHCCC
HAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLKDDPEERNELSAAHPDQCREMIR
CCCCCCEEEEEEECCEEEEEEECCCCCCCCHHHEECCCCCHHHHHHCCCCCHHHHHHHHH
EMSARLEKEGALYPVDKQGNELKPFVYF
HHHHHHHHCCCEEECCCCCCCCCCEEEC
>Mature Secondary Structure
MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSVPFIADESGQPVRHPL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCH
NDWYHTPNMERLAKQGICFSTFYAQSVSSPSRASIMTGQNATRHGVTNWINAESNNRNPF
HHHHCCCCHHHHHHCCCEEEHHHHHHCCCCCCCEEECCCCCCCCCCCCEECCCCCCCCCC
GPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMGSEGENPLNIGFDVNIAGSGI
CCCCCCCHHHHCCCCHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCEEEEEEEEECCCCC
GHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTIEANREITKAVEEKRPFYL
CCCCCCCCCCCEEEECCCEEECCCCHHHHCCCHHHHHHHEEEECCHHHHHHHHHCCCEEE
NMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMDKSLGDIMDQLEKLGIAENT
EEHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LILFLGDNGGDAPLGDERGYGSSAPLRGKKGTEFEGGMRVPFIAAWAKPEKKSKVQKNLP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCC
IEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDLKKQLSGKVDKKRPESFLMHFP
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCCCCCCCCHHHHHCCC
HAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLKDDPEERNELSAAHPDQCREMIR
CCCCCCEEEEEEECCEEEEEEECCCCCCCCHHHEECCCCCHHHHHHCCCCCHHHHHHHHH
EMSARLEKEGALYPVDKQGNELKPFVYF
HHHHHHHHCCCEEECCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]