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The map label for this gene is wecB [H]

Identifier: 29348353

GI number: 29348353

Start: 3706071

End: 3707201

Strand: Reverse

Name: wecB [H]

Synonym: BT_2944

Alternate gene names: 29348353

Gene position: 3707201-3706071 (Counterclockwise)

Preceding gene: 29348354

Following gene: 29348352

Centisome position: 59.22

GC content: 50.04

Gene sequence:

>1131_bases
ATGAAAAAGATATTGCTCGTTTTCGGTACCCGTCCCGAAGCGATAAAGATGGCTCCGCTTGTAAAGGCGCTCCAGAAAGA
TACGGAACATTTTGAGACACGTGTCTGCGTTACGGCACAGCATCGGCAGATGTTGGATCAGGTATTGGAAGTGTTCGGCA
TCACTCCCGAATATGACCTGAATATCATGGCTCCCAATCAGGACTTGTATGACATTACCGCTAAAGTACTCCTTGGACTG
CGCGAAGTGCTGAAGGACTTCCGTCCCGACACCGTATTGGTGCATGGAGATACGACTACCTCGATGGCGGCATCCCTTGC
GGCATTCTATATGCAGATACCTGTGGGACACGTGGAAGCCGGATTGCGTACCTATAATATGTTGTCTCCCTGGCCGGAAG
AAATGAACCGTCAGGTGACAGACCGTATCTGCACTTACTACTTTGCACCGACGGAACAGTCAAAGGTAAATCTACTGCAA
GAGAATATAGACGCGAAGAAAATCTTTATTACCGGAAATACGGTGATCGATGCCCTGCTGATGGCGGTCGATATCATTTC
CACCACCGCCGGTGTGAAAGAAAAGATGGCGAAGGAACTTCAGGAGAAAGGCTACACGGTAGGTGATCGTGAGTATATCC
TCGTCACCGGACATCGTCGCGAGAACTTCGGAGATGGTTTCCTGCATATCTGCAAAGCGATCAAAGAACTGGCGGCTCTT
CACCCGGAGATGGACATAGTCTATCCCGTTCATCTGAATCCTAATGTGCAGAAGCCAGTGTATGAACTGCTTTCCGGTCT
GAGCAATGTCTATCTGATCTCTCCTCTGGATTACCTGCCTTTCATCTATGCCATGCAACATTCTACTCTGTTGCTGACGG
ATAGCGGCGGTGTGCAGGAAGAAGCCCCTTCATTGGGCAAACCCGTGTTGGTGATGCGGGATACGACCGAGCGTCCGGAA
GCTGTTGAGGCGGGTACGGTGAAGCTGGTCGGCACGAATGCGGAGGCAATTGTCAGTAATGTCACTGCCCTGCTCCTTGA
TAAAGAAATGTATAAGCGGATGTCCGAAACACATAACCCTTACGGTGACGGACAGGCTTGCGAAAGAATCATAGCTGCGC
TCAGATGTTAA

Upstream 100 bases:

>100_bases
CCAGGGAGGAAGGAAAGATAGAACTGGACTTCTGCGGTGTGAGACGATAAAAATGTAGTTTAATTGCGAAGAGGTTATAT
AGACTCTATAAATAAAGCAG

Downstream 100 bases:

>100_bases
CACATGAGTAGTCAGGTATTAACATTTGATATGATAGGTATTAATATCTGAGAAGTTAGGTATTAATACTTGAGAAGCTG
GTTAACAATGCTTGCTGTGA

Product: putative UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKKILLVFGTRPEAIKMAPLVKALQKDTEHFETRVCVTAQHRQMLDQVLEVFGITPEYDLNIMAPNQDLYDITAKVLLGL
REVLKDFRPDTVLVHGDTTTSMAASLAAFYMQIPVGHVEAGLRTYNMLSPWPEEMNRQVTDRICTYYFAPTEQSKVNLLQ
ENIDAKKIFITGNTVIDALLMAVDIISTTAGVKEKMAKELQEKGYTVGDREYILVTGHRRENFGDGFLHICKAIKELAAL
HPEMDIVYPVHLNPNVQKPVYELLSGLSNVYLISPLDYLPFIYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRDTTERPE
AVEAGTVKLVGTNAEAIVSNVTALLLDKEMYKRMSETHNPYGDGQACERIIAALRC

Sequences:

>Translated_376_residues
MKKILLVFGTRPEAIKMAPLVKALQKDTEHFETRVCVTAQHRQMLDQVLEVFGITPEYDLNIMAPNQDLYDITAKVLLGL
REVLKDFRPDTVLVHGDTTTSMAASLAAFYMQIPVGHVEAGLRTYNMLSPWPEEMNRQVTDRICTYYFAPTEQSKVNLLQ
ENIDAKKIFITGNTVIDALLMAVDIISTTAGVKEKMAKELQEKGYTVGDREYILVTGHRRENFGDGFLHICKAIKELAAL
HPEMDIVYPVHLNPNVQKPVYELLSGLSNVYLISPLDYLPFIYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRDTTERPE
AVEAGTVKLVGTNAEAIVSNVTALLLDKEMYKRMSETHNPYGDGQACERIIAALRC
>Mature_376_residues
MKKILLVFGTRPEAIKMAPLVKALQKDTEHFETRVCVTAQHRQMLDQVLEVFGITPEYDLNIMAPNQDLYDITAKVLLGL
REVLKDFRPDTVLVHGDTTTSMAASLAAFYMQIPVGHVEAGLRTYNMLSPWPEEMNRQVTDRICTYYFAPTEQSKVNLLQ
ENIDAKKIFITGNTVIDALLMAVDIISTTAGVKEKMAKELQEKGYTVGDREYILVTGHRRENFGDGFLHICKAIKELAAL
HPEMDIVYPVHLNPNVQKPVYELLSGLSNVYLISPLDYLPFIYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRDTTERPE
AVEAGTVKLVGTNAEAIVSNVTALLLDKEMYKRMSETHNPYGDGQACERIIAALRC

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=373, Percent_Identity=61.1260053619303, Blast_Score=459, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42031; Mature: 42031

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLVFGTRPEAIKMAPLVKALQKDTEHFETRVCVTAQHRQMLDQVLEVFGITPEYDL
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCCCCE
NIMAPNQDLYDITAKVLLGLREVLKDFRPDTVLVHGDTTTSMAASLAAFYMQIPVGHVEA
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHH
GLRTYNMLSPWPEEMNRQVTDRICTYYFAPTEQSKVNLLQENIDAKKIFITGNTVIDALL
HHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCEEEEEECHHHHHHHH
MAVDIISTTAGVKEKMAKELQEKGYTVGDREYILVTGHRRENFGDGFLHICKAIKELAAL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HPEMDIVYPVHLNPNVQKPVYELLSGLSNVYLISPLDYLPFIYAMQHSTLLLTDSGGVQE
CCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCC
EAPSLGKPVLVMRDTTERPEAVEAGTVKLVGTNAEAIVSNVTALLLDKEMYKRMSETHNP
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YGDGQACERIIAALRC
CCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILLVFGTRPEAIKMAPLVKALQKDTEHFETRVCVTAQHRQMLDQVLEVFGITPEYDL
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCCCCE
NIMAPNQDLYDITAKVLLGLREVLKDFRPDTVLVHGDTTTSMAASLAAFYMQIPVGHVEA
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHH
GLRTYNMLSPWPEEMNRQVTDRICTYYFAPTEQSKVNLLQENIDAKKIFITGNTVIDALL
HHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCEEEEEECHHHHHHHH
MAVDIISTTAGVKEKMAKELQEKGYTVGDREYILVTGHRRENFGDGFLHICKAIKELAAL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HPEMDIVYPVHLNPNVQKPVYELLSGLSNVYLISPLDYLPFIYAMQHSTLLLTDSGGVQE
CCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCC
EAPSLGKPVLVMRDTTERPEAVEAGTVKLVGTNAEAIVSNVTALLLDKEMYKRMSETHNP
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YGDGQACERIIAALRC
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]