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The map label for this gene is betC [H]

Identifier: 29348323

GI number: 29348323

Start: 3655177

End: 3656598

Strand: Reverse

Name: betC [H]

Synonym: BT_2914

Alternate gene names: 29348323

Gene position: 3656598-3655177 (Counterclockwise)

Preceding gene: 29348324

Following gene: 29348322

Centisome position: 58.41

GC content: 40.86

Gene sequence:

>1422_bases
ATGAAATACACTCAATCTTTTTGTTTTGTAAGTGTGATTGTTTTGTCGTCTTCTGTTCATCTCCATGGACAGAATAATAA
GATGAATGTTTTGCTTATTATTGCCGATGATATGCGTCCTGAATTGGGATGTTATGGAATAGAAGATATTGTGACTCCCC
GTCTGGATAGCTTGGCAAGGTATGCTACGGTCTTTCAGAATGCATATTGTAACATTCCTGTAAGCGGGGCTTCCAGGGCA
AGTCTGTTTACAGGAATGTATCCTCGTTACCCGAATCGTTTTACTGCGTTTGATGCCAGTGCGGAGAAAGATTGTCCGGA
GGCTCTTTCACTTCCGGAATGCTTTAAGAAGAACGGATATTATGTCGTTTCTAATGGAAAAGTATTTCATAATATAACGG
ATCATGCTGATAGTTGGTCGGAAGCTCCATGGAGAGTGCATCCTGATGGATATGGTAAGGATTGGGCTGAATATAACAAG
TGGGAATTATGGCAGAATGAAGAGTCTTCCCGTTATGTTCATCCTAAAACTTTACGAGGTCCTTTCTGTGAGTCGGCTGA
TGTTGCTGATACAACTTACATAGACGGTAGAGTGGCGCAAAAGACAATTGCGGATTTAAGGCGTTTGCATAAAAAGGAAA
AACCGTTTTTTCTTGCATGCGGTTTTTGGAAACCGCATTTGCCTTTCAATGCTCCCAAAAAATACTGGGATTTATATCGG
CGAGAAGAAATACACCTCGCCCAAAATCCTTATAGACCGAAAGCTTTACCTAAACAGGTTACTTCTTCCGGTGAAATTCG
TGGGTATGGGAAATTTGTTACAACTAAAGATGAGACTTTCCAGCGAGAAGCTAAGCATGGCTATTATGCATGTGTGAGTT
ATATTGATGCACAGATTGGTCTGATACTTGACGAACTTGATCGTTTGGGACTGTCTGAGAACACAATAGTGGTAATATTA
GGTGACCATGGTTGGCATTTAGGGGAACATGGATTCTGGGGAAAACATAATCTAATGAATCATGCAACTCGTGCTCCGTT
GATTGTTCGTGTTCCTCATTGTAGAGGTGGCAAAGCAAAAGGAATTGTAGAATTTGTCGATATTTATCCAACTTTGTGCG
AGTTGTGTGGAGTGCCAATGCCTAAGGACCAATTACAGGGAAAGAGTTTTGTGCCTATTTTGCAAGACAGTGGGAAAAAG
ACAAAACAATACGCCTTTATTCAGTGGAAAGGTGGGTATAATATTGTTTCGGAGCAATATAGTAGCACTATATGGCTGCA
AGGAGATTCGGTTGTAGCCCGGATGATATTTGATCGCCAATTGGATGCATCGGAGAATGAAAACAAGGTGCATTGCCCAT
ATTTGAGTAGAGAAAGAGATAAACTTGAGGCTCAGATTAAGATCCGGAAATCTCAATTATAG

Upstream 100 bases:

>100_bases
TCCCTATCTGAAGGAATATAAGAATGATGTTAAAAATAAATTCTCTTTCGAAGGGGTAAACTTTAAATGATATAGTTTTA
GTATTCTGGAGGATGTGGCT

Downstream 100 bases:

>100_bases
AAATAATTTAAAAGAATATATAAATGAAAGTAAGTTCATCTATCATTGCATCTCTTTTGCTTTTGACAGTTTGTAGTTGT
TCAACTCCGAAAAGCGAAAT

Product: iduronate 2-sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKYTQSFCFVSVIVLSSSVHLHGQNNKMNVLLIIADDMRPELGCYGIEDIVTPRLDSLARYATVFQNAYCNIPVSGASRA
SLFTGMYPRYPNRFTAFDASAEKDCPEALSLPECFKKNGYYVVSNGKVFHNITDHADSWSEAPWRVHPDGYGKDWAEYNK
WELWQNEESSRYVHPKTLRGPFCESADVADTTYIDGRVAQKTIADLRRLHKKEKPFFLACGFWKPHLPFNAPKKYWDLYR
REEIHLAQNPYRPKALPKQVTSSGEIRGYGKFVTTKDETFQREAKHGYYACVSYIDAQIGLILDELDRLGLSENTIVVIL
GDHGWHLGEHGFWGKHNLMNHATRAPLIVRVPHCRGGKAKGIVEFVDIYPTLCELCGVPMPKDQLQGKSFVPILQDSGKK
TKQYAFIQWKGGYNIVSEQYSSTIWLQGDSVVARMIFDRQLDASENENKVHCPYLSRERDKLEAQIKIRKSQL

Sequences:

>Translated_473_residues
MKYTQSFCFVSVIVLSSSVHLHGQNNKMNVLLIIADDMRPELGCYGIEDIVTPRLDSLARYATVFQNAYCNIPVSGASRA
SLFTGMYPRYPNRFTAFDASAEKDCPEALSLPECFKKNGYYVVSNGKVFHNITDHADSWSEAPWRVHPDGYGKDWAEYNK
WELWQNEESSRYVHPKTLRGPFCESADVADTTYIDGRVAQKTIADLRRLHKKEKPFFLACGFWKPHLPFNAPKKYWDLYR
REEIHLAQNPYRPKALPKQVTSSGEIRGYGKFVTTKDETFQREAKHGYYACVSYIDAQIGLILDELDRLGLSENTIVVIL
GDHGWHLGEHGFWGKHNLMNHATRAPLIVRVPHCRGGKAKGIVEFVDIYPTLCELCGVPMPKDQLQGKSFVPILQDSGKK
TKQYAFIQWKGGYNIVSEQYSSTIWLQGDSVVARMIFDRQLDASENENKVHCPYLSRERDKLEAQIKIRKSQL
>Mature_473_residues
MKYTQSFCFVSVIVLSSSVHLHGQNNKMNVLLIIADDMRPELGCYGIEDIVTPRLDSLARYATVFQNAYCNIPVSGASRA
SLFTGMYPRYPNRFTAFDASAEKDCPEALSLPECFKKNGYYVVSNGKVFHNITDHADSWSEAPWRVHPDGYGKDWAEYNK
WELWQNEESSRYVHPKTLRGPFCESADVADTTYIDGRVAQKTIADLRRLHKKEKPFFLACGFWKPHLPFNAPKKYWDLYR
REEIHLAQNPYRPKALPKQVTSSGEIRGYGKFVTTKDETFQREAKHGYYACVSYIDAQIGLILDELDRLGLSENTIVVIL
GDHGWHLGEHGFWGKHNLMNHATRAPLIVRVPHCRGGKAKGIVEFVDIYPTLCELCGVPMPKDQLQGKSFVPILQDSGKK
TKQYAFIQWKGGYNIVSEQYSSTIWLQGDSVVARMIFDRQLDASENENKVHCPYLSRERDKLEAQIKIRKSQL

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=424, Percent_Identity=33.0188679245283, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI5360208, Length=342, Percent_Identity=33.6257309941521, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI262118210, Length=327, Percent_Identity=32.4159021406728, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI39930577, Length=411, Percent_Identity=22.3844282238443, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI53831991, Length=454, Percent_Identity=24.8898678414097, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4504061, Length=406, Percent_Identity=21.6748768472906, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790112, Length=460, Percent_Identity=24.1304347826087, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656835, Length=504, Percent_Identity=27.5793650793651, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24647401, Length=422, Percent_Identity=27.2511848341232, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 54122; Mature: 54122

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTQSFCFVSVIVLSSSVHLHGQNNKMNVLLIIADDMRPELGCYGIEDIVTPRLDSLAR
CCCCHHHHHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHH
YATVFQNAYCNIPVSGASRASLFTGMYPRYPNRFTAFDASAEKDCPEALSLPECFKKNGY
HHHHHHCCEECCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCCHHHHHCCCE
YVVSNGKVFHNITDHADSWSEAPWRVHPDGYGKDWAEYNKWELWQNEESSRYVHPKTLRG
EEEECCEEEECCCCCCCCCCCCCCEECCCCCCCCHHHCCCEEECCCCCCCCEECCCCCCC
PFCESADVADTTYIDGRVAQKTIADLRRLHKKEKPFFLACGFWKPHLPFNAPKKYWDLYR
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
REEIHLAQNPYRPKALPKQVTSSGEIRGYGKFVTTKDETFQREAKHGYYACVSYIDAQIG
HCCEEECCCCCCCCCCHHHHCCCCCEEEECCEEECCHHHHHHHHHCCHHHHHHHHHHHHH
LILDELDRLGLSENTIVVILGDHGWHLGEHGFWGKHNLMNHATRAPLIVRVPHCRGGKAK
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCC
GIVEFVDIYPTLCELCGVPMPKDQLQGKSFVPILQDSGKKTKQYAFIQWKGGYNIVSEQY
CHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHCCCCCCCEEEEEEEECCCCCHHHHCC
SSTIWLQGDSVVARMIFDRQLDASENENKVHCPYLSRERDKLEAQIKIRKSQL
CCEEEEECCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHCEEEEEEEECCC
>Mature Secondary Structure
MKYTQSFCFVSVIVLSSSVHLHGQNNKMNVLLIIADDMRPELGCYGIEDIVTPRLDSLAR
CCCCHHHHHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHH
YATVFQNAYCNIPVSGASRASLFTGMYPRYPNRFTAFDASAEKDCPEALSLPECFKKNGY
HHHHHHCCEECCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCCHHHHHCCCE
YVVSNGKVFHNITDHADSWSEAPWRVHPDGYGKDWAEYNKWELWQNEESSRYVHPKTLRG
EEEECCEEEECCCCCCCCCCCCCCEECCCCCCCCHHHCCCEEECCCCCCCCEECCCCCCC
PFCESADVADTTYIDGRVAQKTIADLRRLHKKEKPFFLACGFWKPHLPFNAPKKYWDLYR
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
REEIHLAQNPYRPKALPKQVTSSGEIRGYGKFVTTKDETFQREAKHGYYACVSYIDAQIG
HCCEEECCCCCCCCCCHHHHCCCCCEEEECCEEECCHHHHHHHHHCCHHHHHHHHHHHHH
LILDELDRLGLSENTIVVILGDHGWHLGEHGFWGKHNLMNHATRAPLIVRVPHCRGGKAK
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCC
GIVEFVDIYPTLCELCGVPMPKDQLQGKSFVPILQDSGKKTKQYAFIQWKGGYNIVSEQY
CHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHCCCCCCCEEEEEEEECCCCCHHHHCC
SSTIWLQGDSVVARMIFDRQLDASENENKVHCPYLSRERDKLEAQIKIRKSQL
CCEEEEECCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]