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The map label for this gene is ltrA [H]

Identifier: 29348012

GI number: 29348012

Start: 3241259

End: 3243082

Strand: Reverse

Name: ltrA [H]

Synonym: BT_2602

Alternate gene names: 29348012

Gene position: 3243082-3241259 (Counterclockwise)

Preceding gene: 29348013

Following gene: 29348011

Centisome position: 51.8

GC content: 40.02

Gene sequence:

>1824_bases
ATGAGAAATCCAGAAAATGTGTTGAACAGTCTGAGTAAACACAGCGGTAACTTGAACTATAAGTTTGAGCGGCTGTATAG
AGTGCTGTTTAACGAGGAAATGTTTTATGTAGCCTATCAGAATATTTACAGCAAGACAGGCAACATGACGGCAGGAGCCG
ATGGTAAAACCATTGACGGAATGAGCATTGACCGAGTTGAACAACTGATTGGCAGTCTTAAAAATGAGACTTATCAGCCT
AATCCGTCCAAAAGGACGTACATACCTAAGAAAAACGGGAAAAAACGTCCGCTTGGCATACCCTCTTTTGATGATAAGCT
GGTACAGGAAGTAGTCAGAATGATACTTGAAGCAATCTATGAAGGTAGTTTTGAACATACTTCACATGGGTTTCGTCCCA
AACGAAGTTGTCATACTGCTCTTATAGATATACAAAAGACATTCACTGCCGTGAAATGGTTTATTGAAGGCGATATTAAA
GGATTCTTCGACAATATCAATCATGACGTACTGATTAATATTCTTCGGGAACGTATCGCCGACGAGAGATTTTTGCGGCT
TATCAGAAAATTCCTGAATGCCGGATATGTGGAAGACTGGGTATTTCATAGAACGTACAGTGGAACTCCGCAAGGCGGGA
TTATCAGCCCAATACTGGCTAACATCTACCTTGACAAGTTCGACAAGTACATCAAGGAATACATCAATCGGTTCAATAAA
GGGGTAACAAGAAAAGGCGACGCTCGATACAAGCTCTACGAACAGCGAAGATACCGACTGGCAAAGAAACTAAAGAATGA
GAAAGATGTAAAGGTAAGGAAACAGATGACCGCCGAAATTAAGCGGCTACGAGAAGAACGGAACAACTATCCGGCACGTA
ATGAAATGGACAGCAGTATCAAACGGTTAAAATACGTGAGATACGCAGATGACTTTCTGATTGGAATTACCGGTAATCTT
GAAGACTGCAAAACAGTAAAAGAGGATATTAAGAATTATTTGAATGAAGCTCTTAAACTGGAACTGTCAGACGAAAAGAC
ACTGATAACCAATGCGCAGAAACCAGCGAAATTTCTCGGATATGACGTATTTATACGTAGGTGTAACGATTTACGTAAGG
ATAAGTACGGTAAAACGGTTCGTGCATTCGGACACAAGCCTGTATTGTACCTGAATTTTGAAACGATGCGGAAAAAACTC
TTTGATTATAAAGCCGCAAGAATCGCGGTCGTCAATGGCAAAGAGGTTTGGAAATCCATCGTCAGAACGTACATGCTGAA
CTTGGATGACTTGGAAATAGTCAGTCAGTTCAATGCCGAAATCCGAGGGTTCTATAATTACTACTCAATAGCCAATAACA
GCTATGTCATCAATTCTTTCTATCACATTATGTCATACAGCATGTATAAGGTATTTGCGAACAAATACAAATCATCTGTA
AAGAAAATACTTCTGAAATATAAAAAGAACAAGGTTTTCCAAGTGGCATATGAAAATAGTAAGGGTAAGACACTTTACCA
ATCATTTTATCATGATGGTTTCAAACGCAAAAAGGTTGCAGGGAATATTTACTGTGACACTATTCCACGGACAGTTTCCA
TAACAGGTGGACGTAACAGCCTTATGGAAAGGCTGAAGCTCCAAGTCTGCGAATTATGCGGTGCTACCGATAAACTCGAA
ATGCATCACGTTCGCAAACTTAAAGACCTGAAAGGTAAATCCGACTGGGAAAAGAAAATGATAGCTCGAAGACGAAAAAC
TTTGGCTGTCTGCTCAAAGTGTCATGCAAAAATAGACCCCGACCGAAGAATCAGACTGAATTAA

Upstream 100 bases:

>100_bases
CAACGGAGCTTCCATAGTAGTCTGAGCAGGGTAACGCCCTGTACATGGCGAAGGGGAGCAGCTAATTAAGTTTAACAATT
TAAAGGAAGATGTGAGAGAC

Downstream 100 bases:

>100_bases
TTAGTGGAGAGCCGGATACAGGGAGACTTGTAAGTCCGGTTCGGAGGCGAGTACTCGGAAACCTACCATAGAAATATGAC
AAGGCGCTGGGTGCTTAGCC

Product: putative maturase/reverse transcriptase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MRNPENVLNSLSKHSGNLNYKFERLYRVLFNEEMFYVAYQNIYSKTGNMTAGADGKTIDGMSIDRVEQLIGSLKNETYQP
NPSKRTYIPKKNGKKRPLGIPSFDDKLVQEVVRMILEAIYEGSFEHTSHGFRPKRSCHTALIDIQKTFTAVKWFIEGDIK
GFFDNINHDVLINILRERIADERFLRLIRKFLNAGYVEDWVFHRTYSGTPQGGIISPILANIYLDKFDKYIKEYINRFNK
GVTRKGDARYKLYEQRRYRLAKKLKNEKDVKVRKQMTAEIKRLREERNNYPARNEMDSSIKRLKYVRYADDFLIGITGNL
EDCKTVKEDIKNYLNEALKLELSDEKTLITNAQKPAKFLGYDVFIRRCNDLRKDKYGKTVRAFGHKPVLYLNFETMRKKL
FDYKAARIAVVNGKEVWKSIVRTYMLNLDDLEIVSQFNAEIRGFYNYYSIANNSYVINSFYHIMSYSMYKVFANKYKSSV
KKILLKYKKNKVFQVAYENSKGKTLYQSFYHDGFKRKKVAGNIYCDTIPRTVSITGGRNSLMERLKLQVCELCGATDKLE
MHHVRKLKDLKGKSDWEKKMIARRRKTLAVCSKCHAKIDPDRRIRLN

Sequences:

>Translated_607_residues
MRNPENVLNSLSKHSGNLNYKFERLYRVLFNEEMFYVAYQNIYSKTGNMTAGADGKTIDGMSIDRVEQLIGSLKNETYQP
NPSKRTYIPKKNGKKRPLGIPSFDDKLVQEVVRMILEAIYEGSFEHTSHGFRPKRSCHTALIDIQKTFTAVKWFIEGDIK
GFFDNINHDVLINILRERIADERFLRLIRKFLNAGYVEDWVFHRTYSGTPQGGIISPILANIYLDKFDKYIKEYINRFNK
GVTRKGDARYKLYEQRRYRLAKKLKNEKDVKVRKQMTAEIKRLREERNNYPARNEMDSSIKRLKYVRYADDFLIGITGNL
EDCKTVKEDIKNYLNEALKLELSDEKTLITNAQKPAKFLGYDVFIRRCNDLRKDKYGKTVRAFGHKPVLYLNFETMRKKL
FDYKAARIAVVNGKEVWKSIVRTYMLNLDDLEIVSQFNAEIRGFYNYYSIANNSYVINSFYHIMSYSMYKVFANKYKSSV
KKILLKYKKNKVFQVAYENSKGKTLYQSFYHDGFKRKKVAGNIYCDTIPRTVSITGGRNSLMERLKLQVCELCGATDKLE
MHHVRKLKDLKGKSDWEKKMIARRRKTLAVCSKCHAKIDPDRRIRLN
>Mature_607_residues
MRNPENVLNSLSKHSGNLNYKFERLYRVLFNEEMFYVAYQNIYSKTGNMTAGADGKTIDGMSIDRVEQLIGSLKNETYQP
NPSKRTYIPKKNGKKRPLGIPSFDDKLVQEVVRMILEAIYEGSFEHTSHGFRPKRSCHTALIDIQKTFTAVKWFIEGDIK
GFFDNINHDVLINILRERIADERFLRLIRKFLNAGYVEDWVFHRTYSGTPQGGIISPILANIYLDKFDKYIKEYINRFNK
GVTRKGDARYKLYEQRRYRLAKKLKNEKDVKVRKQMTAEIKRLREERNNYPARNEMDSSIKRLKYVRYADDFLIGITGNL
EDCKTVKEDIKNYLNEALKLELSDEKTLITNAQKPAKFLGYDVFIRRCNDLRKDKYGKTVRAFGHKPVLYLNFETMRKKL
FDYKAARIAVVNGKEVWKSIVRTYMLNLDDLEIVSQFNAEIRGFYNYYSIANNSYVINSFYHIMSYSMYKVFANKYKSSV
KKILLKYKKNKVFQVAYENSKGKTLYQSFYHDGFKRKKVAGNIYCDTIPRTVSITGGRNSLMERLKLQVCELCGATDKLE
MHHVRKLKDLKGKSDWEKKMIARRRKTLAVCSKCHAKIDPDRRIRLN

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=604, Percent_Identity=32.9470198675497, Blast_Score=289, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6226521, Length=590, Percent_Identity=32.8813559322034, Blast_Score=285, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 71392; Mature: 71392

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPENVLNSLSKHSGNLNYKFERLYRVLFNEEMFYVAYQNIYSKTGNMTAGADGKTIDG
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEECC
MSIDRVEQLIGSLKNETYQPNPSKRTYIPKKNGKKRPLGIPSFDDKLVQEVVRMILEAIY
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGSFEHTSHGFRPKRSCHTALIDIQKTFTAVKWFIEGDIKGFFDNINHDVLINILRERIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHH
DERFLRLIRKFLNAGYVEDWVFHRTYSGTPQGGIISPILANIYLDKFDKYIKEYINRFNK
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTRKGDARYKLYEQRRYRLAKKLKNEKDVKVRKQMTAEIKRLREERNNYPARNEMDSSI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KRLKYVRYADDFLIGITGNLEDCKTVKEDIKNYLNEALKLELSDEKTLITNAQKPAKFLG
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHH
YDVFIRRCNDLRKDKYGKTVRAFGHKPVLYLNFETMRKKLFDYKAARIAVVNGKEVWKSI
HHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHEEEEECCHHHHHHH
VRTYMLNLDDLEIVSQFNAEIRGFYNYYSIANNSYVINSFYHIMSYSMYKVFANKYKSSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
KKILLKYKKNKVFQVAYENSKGKTLYQSFYHDGFKRKKVAGNIYCDTIPRTVSITGGRNS
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCEEECCCCCEEEECCCHHH
LMERLKLQVCELCGATDKLEMHHVRKLKDLKGKSDWEKKMIARRRKTLAVCSKCHAKIDP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DRRIRLN
CCCEECC
>Mature Secondary Structure
MRNPENVLNSLSKHSGNLNYKFERLYRVLFNEEMFYVAYQNIYSKTGNMTAGADGKTIDG
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEECC
MSIDRVEQLIGSLKNETYQPNPSKRTYIPKKNGKKRPLGIPSFDDKLVQEVVRMILEAIY
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGSFEHTSHGFRPKRSCHTALIDIQKTFTAVKWFIEGDIKGFFDNINHDVLINILRERIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHH
DERFLRLIRKFLNAGYVEDWVFHRTYSGTPQGGIISPILANIYLDKFDKYIKEYINRFNK
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTRKGDARYKLYEQRRYRLAKKLKNEKDVKVRKQMTAEIKRLREERNNYPARNEMDSSI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KRLKYVRYADDFLIGITGNLEDCKTVKEDIKNYLNEALKLELSDEKTLITNAQKPAKFLG
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHH
YDVFIRRCNDLRKDKYGKTVRAFGHKPVLYLNFETMRKKLFDYKAARIAVVNGKEVWKSI
HHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHEEEEECCHHHHHHH
VRTYMLNLDDLEIVSQFNAEIRGFYNYYSIANNSYVINSFYHIMSYSMYKVFANKYKSSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
KKILLKYKKNKVFQVAYENSKGKTLYQSFYHDGFKRKKVAGNIYCDTIPRTVSITGGRNS
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCEEECCCCCEEEECCCHHH
LMERLKLQVCELCGATDKLEMHHVRKLKDLKGKSDWEKKMIARRRKTLAVCSKCHAKIDP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DRRIRLN
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]