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The map label for this gene is mepA [H]

Identifier: 29347531

GI number: 29347531

Start: 2669625

End: 2670977

Strand: Reverse

Name: mepA [H]

Synonym: BT_2121

Alternate gene names: 29347531

Gene position: 2670977-2669625 (Counterclockwise)

Preceding gene: 29347535

Following gene: 29347529

Centisome position: 42.66

GC content: 48.34

Gene sequence:

>1353_bases
ATGACAGGACAAAAGACACCCACTGCGCTGGGTACGGAAAAGATCGGGAAGCTTTTAATGCAGTACGCCATTCCGGCAAT
TATCGCCATGACGGCATCTTCTCTTTATAATATGGTAGATAGTATTTTCATCGGTCACGGGGTGGGGGCAATGGCTATTT
CGGGGCTGGCACTTACGTTTCCGCTGATGAACCTTGCAGCGGCTTTCGGTTCGCTGGTAGGTGTGGGAGCGGCTACACTG
GTATCGGTGAAGCTGGGACAGAAAGATTATGATACGGCACAACGGGTACTTGGCAATGTGCTGGTATTAAATATTATCAT
CGGACTGGCTTTTACGGTTCTTACCCTGATCTTCCTCGATCCGATTCTTTACTTCTTCGGGGGAAGTGAGGCGACTGTCG
GCTATGCCCGCGACTATATGGTGGTTATCCTCTGGGGAAATGTCATCACCCATCTTTACCTGGGCCTGAATGCGGTACTT
CGTTCCGCAGGGCATCCACAGAAGGCGATGTATGCTACGATTGCTACCGTGGTCATTAATACGATACTCGATCCTATTTT
TATTTACGGCTTTGGCTGGGGAATACAGGGTGCGGCTATCGCTACGATTACCGCACAGGTCATCGCACTTCTCTGGCAGT
TCAAGCTGTTTAGTAATAAGGACGAACTCCTGCATTTTCATAAAGGCATTTTCCGACTGAAAAAGAAGATTGTTTTTGAT
TCTCTGGCCATTGGTATGGCTCCCTTTCTGATGAATCTTGCCGCCTGCTTTATCGTCATCCTTATTAATAAGGGGCTGAA
ACAGCACGGAGGGGATCTGGCTATCGGAGCTTTCGGCATTGTCAACCGTCTGGTATTCCTCTTCGTTATGATTGTGATGG
GTTTGAATCAGGGAATGCAGCCCATTGCCGGCTATAACTTCGGCGCCAAACAGTATCCGCGCGTGACGCAAGTGCTGAAA
ATAACGATTTATGCCGCGACCATTGTTACAACCATCGGTTTTCTGATGGGAATGTTTATTCCGCAACTGGCTGTTTCTAT
CTTTACGACGCACGAAGAATTGGTGAATATCTCGGCAAAGGGCTTACGGATTGTTGTGATGTTTTTCCCGATTGTCGGTT
TTCAGATGGTGACTTCCAACTTCTTCCAGAGTATCGGTATGGCGAGCAAGGCTATCTTTCTCTCTATTTCCCGTCAGGTG
CTTGTACTGATTCCTTGCCTGTTGATTCTTCCCCGGTTTTACGGGCAGCTCGGCGTGTGGATCAGTATGCCTATCTCTGA
TTTGATAGCCAGTCTGATTGCAGGAGGGATGCTTTGGTGGCAGTTCCGTCAGTTCAGAAAGGCAACTGCCTGA

Upstream 100 bases:

>100_bases
TATGTATTAACTCAATTTTGGAGGCAAAAATACGAAACTTTTCTCATATATCCTGTAATCCGTCTCTTTTTTGTATCTTT
GCGCCCTCAAAACAATAGGT

Downstream 100 bases:

>100_bases
TCTGTTTATTCCGATACTCTTTCGGAGAGACACCTACGTATTGCTTGAAATACTTACCGAAGAAAGACTGAGTCGGGAAA
TTCAGCTTTGTTGCAATTTC

Product: putative Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTGQKTPTALGTEKIGKLLMQYAIPAIIAMTASSLYNMVDSIFIGHGVGAMAISGLALTFPLMNLAAAFGSLVGVGAATL
VSVKLGQKDYDTAQRVLGNVLVLNIIIGLAFTVLTLIFLDPILYFFGGSEATVGYARDYMVVILWGNVITHLYLGLNAVL
RSAGHPQKAMYATIATVVINTILDPIFIYGFGWGIQGAAIATITAQVIALLWQFKLFSNKDELLHFHKGIFRLKKKIVFD
SLAIGMAPFLMNLAACFIVILINKGLKQHGGDLAIGAFGIVNRLVFLFVMIVMGLNQGMQPIAGYNFGAKQYPRVTQVLK
ITIYAATIVTTIGFLMGMFIPQLAVSIFTTHEELVNISAKGLRIVVMFFPIVGFQMVTSNFFQSIGMASKAIFLSISRQV
LVLIPCLLILPRFYGQLGVWISMPISDLIASLIAGGMLWWQFRQFRKATA

Sequences:

>Translated_450_residues
MTGQKTPTALGTEKIGKLLMQYAIPAIIAMTASSLYNMVDSIFIGHGVGAMAISGLALTFPLMNLAAAFGSLVGVGAATL
VSVKLGQKDYDTAQRVLGNVLVLNIIIGLAFTVLTLIFLDPILYFFGGSEATVGYARDYMVVILWGNVITHLYLGLNAVL
RSAGHPQKAMYATIATVVINTILDPIFIYGFGWGIQGAAIATITAQVIALLWQFKLFSNKDELLHFHKGIFRLKKKIVFD
SLAIGMAPFLMNLAACFIVILINKGLKQHGGDLAIGAFGIVNRLVFLFVMIVMGLNQGMQPIAGYNFGAKQYPRVTQVLK
ITIYAATIVTTIGFLMGMFIPQLAVSIFTTHEELVNISAKGLRIVVMFFPIVGFQMVTSNFFQSIGMASKAIFLSISRQV
LVLIPCLLILPRFYGQLGVWISMPISDLIASLIAGGMLWWQFRQFRKATA
>Mature_449_residues
TGQKTPTALGTEKIGKLLMQYAIPAIIAMTASSLYNMVDSIFIGHGVGAMAISGLALTFPLMNLAAAFGSLVGVGAATLV
SVKLGQKDYDTAQRVLGNVLVLNIIIGLAFTVLTLIFLDPILYFFGGSEATVGYARDYMVVILWGNVITHLYLGLNAVLR
SAGHPQKAMYATIATVVINTILDPIFIYGFGWGIQGAAIATITAQVIALLWQFKLFSNKDELLHFHKGIFRLKKKIVFDS
LAIGMAPFLMNLAACFIVILINKGLKQHGGDLAIGAFGIVNRLVFLFVMIVMGLNQGMQPIAGYNFGAKQYPRVTQVLKI
TIYAATIVTTIGFLMGMFIPQLAVSIFTTHEELVNISAKGLRIVVMFFPIVGFQMVTSNFFQSIGMASKAIFLSISRQVL
VLIPCLLILPRFYGQLGVWISMPISDLIASLIAGGMLWWQFRQFRKATA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48927; Mature: 48795

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGQKTPTALGTEKIGKLLMQYAIPAIIAMTASSLYNMVDSIFIGHGVGAMAISGLALTF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH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EECCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA