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The map label for this gene is ilvG [H]

Identifier: 29347487

GI number: 29347487

Start: 2601514

End: 2603211

Strand: Reverse

Name: ilvG [H]

Synonym: BT_2077

Alternate gene names: 29347487

Gene position: 2603211-2601514 (Counterclockwise)

Preceding gene: 29347488

Following gene: 29347486

Centisome position: 41.58

GC content: 50.65

Gene sequence:

>1698_bases
ATGAGTAAGGACTTAATAACAGGCGCAGAGGCAATGATGCGCTCTCTGGAACATCAGGGAGTGACTACCATTTTCGGTTA
TCCCGGCGGTTCCATCATGCCTACGTTCGATGCCCTGTACGACCATCAAAATACATTGAACCATATCTTGGTTCGCCATG
AACAGGGAGCTGCCCATGCGGCACAAGGCTACGCCCGTGTATCGGGTAAAGTCGGTGTTTGCTTGGTGACAAGCGGCCCC
GGAGCAACCAATACGATCACAGGTATTGCAGATGCGATGATAGACAGTACGCCTATCGTTGTCATTGCAGGACAGGTGGG
AACAGGCTTTCTTGGAACAGACGCTTTTCAGGAAGTCGATCTCGTAGGTATCACTCAGCCAATCGCTAAATGGAGCTATC
AGATTCGCCGTGCCGAAGACGTAGCCTGGGCGATAGCACGTGCTTTCTACATTGCCAGTAGTGGTCGTCCCGGTCCGGTG
GTACTCGACTTTGCCAAGAATGCGCAGGTTGAAAAAACGAAATACGAGCCGACAAAGCAGGAGTTTATCCGCAGCTATGT
TCCGGTTCCCGATACAGACGAAGAATCAGTAAAGGCTGCCGCCGAACTGATCAATAACGCCGAACGCCCGCTTGTCTTGG
TAGGACAGGGAGTGGAACTGGGAAGCGCTCAGGAAGAACTGCGTATCTTTATCGAAAAGGCGGATATGCCCGCAGGTTGT
ACCTTGCTCGGACTTTCCGCATTGCCTACCGACCATCCGTTGAATAAAGGAATGCTGGGTATGCACGGAAATCTGGGACC
GAATATCAATACTAACAAATGTGATGTACTGATTGCTGTCGGTATGCGTTTCGACGACCGTGTGACCGGTAATCTGGCTA
CTTACGCCAAACAAGCGAAAGTGATCCATTTTGACATTGATCCGGCGGAAGTAAATAAGAATGTAAAGGTAGACATTGCC
GTTTTGGGCGACTGCAAAAAGACGCTGGCTGCTGTGACCGGACTGCTGAAAAAGAACCGGCACACCGAGTGGGTCGATAG
TTTCAAGGAATATGAAGCGGTAGAGGAAGAAAAAGTCATTCGTCCCGAACTTCATCCTGCAACGGATTCACTGAGTATGG
GCGAAGTGGTGCGTGCGGTAAGCGAAGCGACCCGTCACGAAGCCATATTGGTGACAGATGTAGGTCAGAATCAGATGATC
TCTGCCCGCTACTTTAAATATACCAGGGAACGTAGTATCGTTACTTCGGGTGGACTCGGCACGATGGGTTTTGGCCTTCC
GGCAGCTATCGGAGCTACTTTCGGCCGTCCCGACCGCACGGTATGTGTATTTATGGGTGACGGCGGACTGCAAATGAACA
TTCAGGAGCTGGGTACGATCATGGAACAGAAAGCTCCGGTGAAGATTATCTGCCTGAACAACAATTATCTCGGCAACGTG
CGCCAATGGCAGGCTATGTTCTTTAATCGCCGTTATTCATTTACTCCGATGCTGAATCCGGATTACATGAAAATCGCTTC
CGCCTACGATATTCCTTCCAAACGTGTCTTTTCACGGGAAGAATTGAAAGCGGCCATCGACGAAATGCTCTCGACAGACG
GGGCGTTCCTGCTCGAAGCCTGTGTGGTAGAAGAAGGCAATGTCCTCCCGATGACCCCTCCGGGCGGTTCAGTCAATCAG
ATGTTGCTGGAATGTTAA

Upstream 100 bases:

>100_bases
ACGCCAGCATGGTAAGCTCTGCCGATAAGGGAGCAGTGAGATTAATAGACTGATCCACTTCATTATCCATTATGAATCAT
CCATTATCCATTAAAGAACT

Downstream 100 bases:

>100_bases
TCCTTAATTTAGAAAGTTATGAGTGATAAGACATTATATACGATTATAGTTCATTCTGAAAATATAGCCGGATTGCTGAA
TCAGGTGACCGCTGTATTTA

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGP
GATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPV
VLDFAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMPAGC
TLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIA
VLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMI
SARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNV
RQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQ
MLLEC

Sequences:

>Translated_565_residues
MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGP
GATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPV
VLDFAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMPAGC
TLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIA
VLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMI
SARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNV
RQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQ
MLLEC
>Mature_564_residues
SKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPG
ATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVV
LDFAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMPAGCT
LLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAV
LGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMIS
ARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNVR
QWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQM
LLEC

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=506, Percent_Identity=26.6798418972332, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI93004078, Length=561, Percent_Identity=26.2032085561497, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI87081685, Length=568, Percent_Identity=40.669014084507, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1790104, Length=565, Percent_Identity=41.5929203539823, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1786717, Length=533, Percent_Identity=30.3939962476548, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=27.7477477477477, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788716, Length=479, Percent_Identity=27.9749478079332, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17542570, Length=524, Percent_Identity=25.9541984732824, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=562, Percent_Identity=26.6903914590747, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531301, Length=562, Percent_Identity=26.6903914590747, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323755, Length=589, Percent_Identity=38.5398981324278, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6320816, Length=492, Percent_Identity=24.5934959349593, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321524, Length=297, Percent_Identity=21.8855218855219, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922626, Length=492, Percent_Identity=28.2520325203252, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61409; Mature: 61278

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQGAAHA
CCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCHHHHHHEEEECCCCCCHH
AQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVD
HCCHHEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCC
LVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLDFAKNAQVEKTKYEPTKQ
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCCCCCCCHHH
EFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMPAGC
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCCC
TLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAK
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCE
VIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVI
EEEEECCHHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
RPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRERSIVTSGGLG
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHCCCEEECCCCC
TMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNV
CCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCH
RQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHH
CVVEEGNVLPMTPPGGSVNQMLLEC
HHHCCCCEEEECCCCCCHHHHHHCC
>Mature Secondary Structure 
SKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQGAAHA
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCHHHHHHEEEECCCCCCHH
AQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVD
HCCHHEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCC
LVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLDFAKNAQVEKTKYEPTKQ
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCCCCCCCHHH
EFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMPAGC
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCCC
TLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAK
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCE
VIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVI
EEEEECCHHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
RPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRERSIVTSGGLG
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHCCCEEECCCCC
TMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNV
CCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCH
RQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHH
CVVEEGNVLPMTPPGGSVNQMLLEC
HHHCCCCEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]