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The map label for this gene is ilvD [H]

Identifier: 29347488

GI number: 29347488

Start: 2603259

End: 2605061

Strand: Reverse

Name: ilvD [H]

Synonym: BT_2078

Alternate gene names: 29347488

Gene position: 2605061-2603259 (Counterclockwise)

Preceding gene: 29347490

Following gene: 29347487

Centisome position: 41.61

GC content: 50.08

Gene sequence:

>1803_bases
ATGAAAAAGCAATTACGCAGTTCGTTTAGTACACAAGGCCGTCGCATGGCGGGAGCCCGCGCATTATGGGCAGCCAACGG
CATGAAGAAAAATCAGATGGGAAAACCCATTATCGCTATCGTCAATTCGTTTACACAATTTGTTCCGGGACACGTGCACC
TGCATGAAATCGGGCAGTTGGTGAAGGCGGAAATTGAGAAGCTGGGATGCTTCGCTGCGGAATTTAATACGATTGCTATT
GATGACGGTATCGCTATGGGACATGACGGAATGCTTTACTCGCTTCCTTCCCGTGATATCATAGCGGACAGCGTAGAATA
TATGGTCAATGCGCACAAGGCGGATGCAATGGTATGTATCAGCAACTGCGATAAGATTACCCCAGGGATGCTGATGGCTG
CCATGCGCCTGAATATCCCTACCGTATTTGTATCCGGCGGACCGATGGAAGCCGGAGAGTGGAACGGTCAGCATCTGGAC
TTGATCGATGCCATGATTAAATCGGCGGACGACAGTGTAAGCGATCAGGAAGTAGCGAATATCGAACAGAATGCCTGTCC
TACCTGCGGATGTTGTTCCGGAATGTTTACGGCAAACTCGATGAACTGTCTGAATGAAGCTATCGGCTTGGCTCTTCCGG
GAAACGGCACAATCGTGGCTACGCACGAAAATCGTACGAAACTGTTTGAAGATGCTGCCAAACTGATTGTGGAAAATGCA
ATGAAATATTATGAAGAAGGTGACGAAAGTGTACTTCCCCGCAGCATAGCTACCCGTCAGGCATTCCTCAATGCCATGAC
GCTGGATATTGCGATGGGCGGTTCTACCAATACGGTGCTTCACCTGTTGGCCGTGGCACATGAGGCAGGAGTCGATTTCA
AGATGGACGACATCGATATGCTGTCACGCAAGACACCCTGCCTGTGTAAAGTCGCTCCGAATACTCAAAAATATCATATT
CAGGACGTTAACCGTGCGGGTGGCATCATTGCTATCCTGGCAGAGTTGGCAAAAGGCGGTCTGATTGATACTTCCGTTCT
CCGTGTGGATGGCATGTCGCTGGCGGAAGCGATCGATCAATATTCAATTACCAGCCCGAACGTTACGGAAAAAGCAATGA
GCAAATATTCAAGTGCGGCAGGAAACAGATTCAATCTCGTACTTGGTTCTCAGGGAGCTTATTATCAGGAATTAGATAAA
GATCGCGCGAACGGATGTATCCGTGATCTGGAGCACGCCTATAGCAAGGACGGAGGTTTGGCGGTACTGAAAGGAAATAT
CGCTCAGGACGGTTGCGTAGTAAAAACGGCGGGTGTAGACGAAAGCATCTGGAAGTTTACCGGACCTGCCAAAGTATTCG
ACTCACAAGAAGCAGCCTGTGAAGGCATCCTCGGAGGCCGAGTCGTCAGCGGCGACGTTGTCGTCATCACGCACGAAGGT
CCGAAGGGCGGTCCCGGTATGCAGGAAATGCTTTACCCGACTTCTTATATCAAATCCCGTCACCTCGGCAAAGAATGTGC
CTTGATTACCGACGGACGTTTCAGTGGTGGAACTTCCGGATTGAGTATCGGACACGTTTCTCCCGAAGCCGCTGCCGGAG
GTAATATAGGAAAAATAGTAGATGGAGATATCATCGAAATCGACATTCCCGCCCGAACGATTAACGTGCGACTAACAGAT
GAAGAACTGGCTGCCCGCCCGATGACTCCCGTCACCCGTGACCGTTACGTGCCGAAGAGCCTGAAAGCATACGCCAGCAT
GGTAAGCTCTGCCGATAAGGGAGCAGTGAGATTAATAGACTGA

Upstream 100 bases:

>100_bases
GTGAGAAAGGTTTTGTGTATGTATTCGTACCATAAAAGATAGAATTTGGAGCCTTTCTCACTGATGTGAGGGAGGCTCTT
TAATTAAAAGATAGATTGAA

Downstream 100 bases:

>100_bases
TCCACTTCATTATCCATTATGAATCATCCATTATCCATTAAAGAACTATGAGTAAGGACTTAATAACAGGCGCAGAGGCA
ATGATGCGCTCTCTGGAACA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLD
LIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENA
MKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHI
QDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDK
DRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTD
EELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID

Sequences:

>Translated_600_residues
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLD
LIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENA
MKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHI
QDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDK
DRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTD
EELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID
>Mature_600_residues
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLD
LIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENA
MKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHI
QDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDK
DRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTD
EELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=65.3530377668309, Blast_Score=799, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=509, Percent_Identity=32.6129666011788, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788157, Length=569, Percent_Identity=28.8224956063269, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=31.8811881188119, Blast_Score=190, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=600, Percent_Identity=36, Blast_Score=330, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64046; Mature: 64046

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQL
CCHHHHHHHHHCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHH
VKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHHHHEEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLIDAMIKSADDSVSDQEVAN
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
IEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENA
HHHCCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
MKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDM
HHHHHCCCCHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCCCEECCHHH
LSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQ
HHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEECCEEEECCHHHHHHHHH
YSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDKDRANGCIRDLEHAYSKDGGL
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
AVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEG
EEEECCCCCCCEEEEECCCCHHHHHCCCCHHHCCCHHHHHHHCCCCEEEECCEEEEEECC
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIV
CCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCHHHCCCCCCEEC
DGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID
CCCEEEEEECCEEEEEEEEHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQL
CCHHHHHHHHHCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHH
VKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHHHHEEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLIDAMIKSADDSVSDQEVAN
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
IEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENA
HHHCCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
MKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDM
HHHHHCCCCHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCCCEECCHHH
LSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQ
HHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEECCEEEECCHHHHHHHHH
YSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDKDRANGCIRDLEHAYSKDGGL
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
AVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEG
EEEECCCCCCCEEEEECCCCHHHHHCCCCHHHCCCHHHHHHHCCCCEEEECCEEEEEECC
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIV
CCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCHHHCCCCCCEEC
DGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID
CCCEEEEEECCEEEEEEEEHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA