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The map label for this gene is rmlA2 [H]

Identifier: 29347427

GI number: 29347427

Start: 2531321

End: 2532196

Strand: Reverse

Name: rmlA2 [H]

Synonym: BT_2017

Alternate gene names: 29347427

Gene position: 2532196-2531321 (Counterclockwise)

Preceding gene: 29347428

Following gene: 29347426

Centisome position: 40.45

GC content: 50.46

Gene sequence:

>876_bases
ATGAAAGGAATTATTCTGGCCGGTGGAAGCGCCACTCGTCTTTATCCGCTTTCCAAAGCGATTTCCAAACAAATCATGCC
TGTATACGACAAGCCGATGATCTATTATCCGCTGTCTACGCTTATGCTGGCAGGGATACGGGAGGTCTTGATCATCTCTA
CTCCGCGTGATTTGCCGATGTTTCGGGACTTGTTGGGCTCAGGTGAGGAGCTCGGGATGTCTTTCTCTTACAAAATACAG
GAGCAGCCTAACGGACTGGCACAAGCCTTTGTGTTGGGAGCTGATTTCTTGAACGGTGAGGCAGGTTGTCTGATTCTTGG
GGACAATATGTTTTATGGACAAGGGTTTTCCGCTATGCTCCGGCGTGCTGCCGGTGTGGAGAAGGGAGCCTGCATCTTCG
GCTATTACGTGAAAGATCCTCGGGCTTACGGTGTAGTGGAGTTCGACGAACAAGGCAAAGTGATTTCTCTGGAAGAAAAG
CCACTGGTGCCGAAAAGTAATTATGCCGTTCCCGGACTTTATTTCTACGACGCTACCGTGACGGAAAAAGCGGCTTCTCT
CCGCCCTTCGGCACGTGGAGAATATGAGATAACGGACCTGAACCGCCTGTACCTCGAAGAAGGAACACTGAACGTGGAAC
TGTTCGGACGCGGATTCGCATGGCTGGATACTGGAAACTGCGACAGCCTGCTCGAAGCCTCCAACTTCGTGGCTACCATT
CAGAACCGGCAAGGCTTCTACGTCAGCTGTATCGAAGAGATAGCCTGGCGGCAAGGATGGATTTCGTCCGGACAATTGCT
GCTGCTCGGACAGAAACTCGAAAAGACCGAATACGGTAAATACCTGATAGAACTGTCTAAACAACCCTTGAAATAA

Upstream 100 bases:

>100_bases
AAGTTATTGAACTGGCAGGATAGATTTCTTACAATTCATTTTGTCACGTCAGATTTCTTTCCGACCTTTGCACACAGTAA
AATGAATAACTCAGACGACA

Downstream 100 bases:

>100_bases
ACATAAATAATCATATATGAAAACTTATCTGGTGACCGGTGCCGCAGGATTTATTGGCGCCAATTATATTAAGTATATCT
TGGCCAAGCACAGCGATATA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGSATRLYPLSKAISKQIMPVYDKPMIYYPLSTLMLAGIREVLIISTPRDLPMFRDLLGSGEELGMSFSYKIQ
EQPNGLAQAFVLGADFLNGEAGCLILGDNMFYGQGFSAMLRRAAGVEKGACIFGYYVKDPRAYGVVEFDEQGKVISLEEK
PLVPKSNYAVPGLYFYDATVTEKAASLRPSARGEYEITDLNRLYLEEGTLNVELFGRGFAWLDTGNCDSLLEASNFVATI
QNRQGFYVSCIEEIAWRQGWISSGQLLLLGQKLEKTEYGKYLIELSKQPLK

Sequences:

>Translated_291_residues
MKGIILAGGSATRLYPLSKAISKQIMPVYDKPMIYYPLSTLMLAGIREVLIISTPRDLPMFRDLLGSGEELGMSFSYKIQ
EQPNGLAQAFVLGADFLNGEAGCLILGDNMFYGQGFSAMLRRAAGVEKGACIFGYYVKDPRAYGVVEFDEQGKVISLEEK
PLVPKSNYAVPGLYFYDATVTEKAASLRPSARGEYEITDLNRLYLEEGTLNVELFGRGFAWLDTGNCDSLLEASNFVATI
QNRQGFYVSCIEEIAWRQGWISSGQLLLLGQKLEKTEYGKYLIELSKQPLK
>Mature_291_residues
MKGIILAGGSATRLYPLSKAISKQIMPVYDKPMIYYPLSTLMLAGIREVLIISTPRDLPMFRDLLGSGEELGMSFSYKIQ
EQPNGLAQAFVLGADFLNGEAGCLILGDNMFYGQGFSAMLRRAAGVEKGACIFGYYVKDPRAYGVVEFDEQGKVISLEEK
PLVPKSNYAVPGLYFYDATVTEKAASLRPSARGEYEITDLNRLYLEEGTLNVELFGRGFAWLDTGNCDSLLEASNFVATI
QNRQGFYVSCIEEIAWRQGWISSGQLLLLGQKLEKTEYGKYLIELSKQPLK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=248, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI11761621, Length=248, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=61.0526315789474, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1788351, Length=286, Percent_Identity=60.4895104895105, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=27.6041666666667, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=250, Percent_Identity=26, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355443, Length=233, Percent_Identity=25.7510729613734, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=233, Percent_Identity=25.7510729613734, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32294; Mature: 32294

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSATRLYPLSKAISKQIMPVYDKPMIYYPLSTLMLAGIREVLIISTPRDLPM
CCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FRDLLGSGEELGMSFSYKIQEQPNGLAQAFVLGADFLNGEAGCLILGDNMFYGQGFSAML
HHHHHCCCHHHCCEEEEEEECCCCHHHHHHEEEHHHCCCCCCEEEEECCEEECCCHHHHH
RRAAGVEKGACIFGYYVKDPRAYGVVEFDEQGKVISLEEKPLVPKSNYAVPGLYFYDATV
HHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEECHH
TEKAASLRPSARGEYEITDLNRLYLEEGTLNVELFGRGFAWLDTGNCDSLLEASNFVATI
HHHHHHCCCCCCCCEEEECCEEEEEECCEEEEEEEECCEEEEECCCCHHHHHHCCEEEEE
QNRQGFYVSCIEEIAWRQGWISSGQLLLLGQKLEKTEYGKYLIELSKQPLK
ECCCCEEHHHHHHHHHHCCCCCCCCEEEEECHHCHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MKGIILAGGSATRLYPLSKAISKQIMPVYDKPMIYYPLSTLMLAGIREVLIISTPRDLPM
CCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FRDLLGSGEELGMSFSYKIQEQPNGLAQAFVLGADFLNGEAGCLILGDNMFYGQGFSAML
HHHHHCCCHHHCCEEEEEEECCCCHHHHHHEEEHHHCCCCCCEEEEECCEEECCCHHHHH
RRAAGVEKGACIFGYYVKDPRAYGVVEFDEQGKVISLEEKPLVPKSNYAVPGLYFYDATV
HHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEECHH
TEKAASLRPSARGEYEITDLNRLYLEEGTLNVELFGRGFAWLDTGNCDSLLEASNFVATI
HHHHHHCCCCCCCCEEEECCEEEEEECCEEEEEEEECCEEEEECCCCHHHHHHCCEEEEE
QNRQGFYVSCIEEIAWRQGWISSGQLLLLGQKLEKTEYGKYLIELSKQPLK
ECCCCEEHHHHHHHHHHCCCCCCCCEEEEECHHCHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]