| Definition | Bacteroides thetaiotaomicron VPI-5482 chromosome, complete genome. |
|---|---|
| Accession | NC_004663 |
| Length | 6,260,361 |
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The map label for this gene is dxr
Identifier: 29347412
GI number: 29347412
Start: 2518622
End: 2519794
Strand: Reverse
Name: dxr
Synonym: BT_2002
Alternate gene names: 29347412
Gene position: 2519794-2518622 (Counterclockwise)
Preceding gene: 29347413
Following gene: 29347411
Centisome position: 40.25
GC content: 55.16
Gene sequence:
>1173_bases ATGGATTCAGAAAAGAAGAATAAGAAGAAACAAATAGCTATTTTAGGCTCTACGGGCTCTATCGGGACGCAGGCGTTGCA GGTGATCGAAGAACACCCCGACCTCTACGAAGCCTATGCCCTGACGGCCAACAACCGGGTAGAACTGCTGATTGCACAGG CACGCAAGTTCCAGCCGGAAGTGGTGGTGATAGCCAACGAAGAAAAGTACGCCCAACTGAAGGAAGCGCTGAGCGACCTT CCGATCAAAGTATATGCCGGAATCGACGCGGTCTGTCAGATCGTGGAGGCCGGACCGGTAGATATGGTGCTGACGGCAAT GGTGGGCTATGCCGGACTGAAGCCGACGATCAACGCCATTCGTGCCAAGAAAGCCATTGCGCTTGCCAATAAGGAGACGC TTGTGGTGGCGGGAGAACTGATCAACCAACTGGCACAGCAATACCACACTCCCATTTTGCCGGTGGACTCTGAACACTCG GCAGTCTTCCAGTGTTTAGCTGGAGAAGTCGGGAACCCGATTGAGAAGGTGATACTGACCGCTTCCGGTGGTCCGTTTCG GACCTGCACGCTGGAGCAGCTGAAGTCCGTCACCAAGACACAGGCATTGAAACATCCCAACTGGGAGATGGGAGCCAAGA TCACCATTGACTCCGCATCCATGATGAACAAAGGCTTTGAGGTCATCGAGGCGAAATGGCTGTTCGGCGTGCAGCCCAGC CAGATCGAGGTGGTGGTGCATCCGCAGTCGGTCATTCATTCCATGGTGCAGTTTGAGGACGGTGCCGTCAAGGCACAGCT AGGCATGCCGGATATGCGTCTGCCCATCCAGTATGCGTTCTCGTATCCCGACCGTATCTGCTCTTCTTTCGACAGGCTCG ACTTCACCCAGTGCACGAACCTGACGTTCGAGCAACCGGATACGAAGCGTTTCCGCAACCTTGCCCTGGCTTACGAGGCG ATGTATCGGGGCGGAAATATGCCTTGCATTGTCAATGCCGCCAACGAAGTAGTGGTAGCCGCTTTCCTCCGGGACGGCAT CAGCTTCCTCGGTATGAGCGATGTGATCGAAAAGACAATGGAACGTGCCGCGTTTGTAGCCGCTCCTGCTTACGACGACT ATGTGGCTACCGACGCTGAAGCGCGGAGAATAGCTGCGGAGCTGATTCCGTGA
Upstream 100 bases:
>100_bases ACATCCTGTCAATCCGGAGAAATACATCGTGTTTTAAAGCCAATGACGAGAAGTGGGATATACGATTATAAGTGACAAGT GACAGAGGAATTAGATAATA
Downstream 100 bases:
>100_bases TAGCACCGGAGCTGATTTCGTGAACAATGAAAAATATAAATAAGTAATATAAATTAGAAAGCGCCTCGGTTTTCCTCTTA TGAGCAGAGGGTTTGGATGA
Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Products: NA
Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase
Number of amino acids: Translated: 390; Mature: 390
Protein sequence:
>390_residues MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP
Sequences:
>Translated_390_residues MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP >Mature_390_residues MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP
Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
COG id: COG0743
COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DXR family
Homologues:
Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=43.8144329896907, Blast_Score=311, Evalue=4e-86,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DXR_BACTN (Q8A684)
Other databases:
- EMBL: AE015928 - RefSeq: NP_810915.1 - ProteinModelPortal: Q8A684 - SMR: Q8A684 - GeneID: 1076106 - GenomeReviews: AE015928_GR - KEGG: bth:BT_2002 - NMPDR: fig|226186.1.peg.2002 - HOGENOM: HBG430762 - OMA: IHSMVEY - PhylomeDB: Q8A684 - ProtClustDB: PRK05447 - BioCyc: BTHE226186:BT_2002-MONOMER - BRENDA: 1.1.1.267 - HAMAP: MF_00183 - InterPro: IPR003821 - InterPro: IPR013644 - InterPro: IPR013512 - InterPro: IPR016040 - Gene3D: G3DSA:3.40.50.720 - PIRSF: PIRSF006205 - TIGRFAMs: TIGR00243
Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom
EC number: =1.1.1.267
Molecular weight: Translated: 42743; Mature: 42743
Theoretical pI: Translated: 5.15; Mature: 5.15
Prosite motif: NA
Important sites: BINDING 131-131 BINDING 158-158 BINDING 182-182 BINDING 205-205 BINDING 227-227
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 4.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 4.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPE CCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHEEEECCCCEEEEEEHHHCCCCC VVVIANEEKYAQLKEALSDLPIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAI EEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH RAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHSAVFQCLAGEVGNPIEKVILT HHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEE ASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS ECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHEEEEEEECCCCC QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTN EEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHCC LTFEQPDTKRFRNLALAYEAMYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTM CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCHHHCCHHHHHHHHH ERAAFVAAPAYDDYVATDAEARRIAAELIP HHHHEEECCCCCCHHCCCHHHHHHHHHCCC >Mature Secondary Structure MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPE CCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHEEEECCCCEEEEEEHHHCCCCC VVVIANEEKYAQLKEALSDLPIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAI EEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH RAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHSAVFQCLAGEVGNPIEKVILT HHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEE ASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS ECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHEEEEEEECCCCC QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTN EEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHCC LTFEQPDTKRFRNLALAYEAMYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTM CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCHHHCCHHHHHHHHH ERAAFVAAPAYDDYVATDAEARRIAAELIP HHHHEEECCCCCCHHCCCHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12663928