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The map label for this gene is mscM [H]

Identifier: 29347033

GI number: 29347033

Start: 1998220

End: 1999395

Strand: Reverse

Name: mscM [H]

Synonym: BT_1623

Alternate gene names: 29347033

Gene position: 1999395-1998220 (Counterclockwise)

Preceding gene: 29347034

Following gene: 29347024

Centisome position: 31.94

GC content: 46.26

Gene sequence:

>1176_bases
ATGTTAGTAGTCGATTTAGGAAAATGGATGAACAAAATCCTGATAGATTGGGGGATAGATGCGAAGGTTGCCGATCGTTT
TGATGAAACAATTATTGCTATACTGATGATAGCCATTGCTGTAGGGGTGGACTATCTTTGTCAGGCAATTCTAGTGGGAG
GAATGAGGCAGTATACCCGCAGGAAACCGCATCTTTGGAATACATTGCTGATGAAACGTAAAGTGTTTCATAATCTGATT
CATACGATTCCCGCCATCCTTGTCTATGCCCTGTTGCCGATGGCTTTCATGCGTGGCAAGGAACTGCTGGTTATTTCGCA
GAAGGCTTGTGCCATTTATATCATCTTTTCTTTGCTGCTGGCTATCAATGGGATTCTGCTGATGATCATGGATATTTACG
ATGGAAAGGAGACAATGAAGAACCGGCCGATGAAAGGATTCATTCAAGTACTTCAGGTACTTTTGTTTTTTATCGGGGGG
ATTGTGATTATCTCTATCCTTGTAAATAAATCGCCTGCCAGTCTGTTTGCGGGACTGGGTGCTTCGGCAGCCATCCTGAT
GCTGGTATTCAAGGATTCCATTTTGGGATTTGTGGCAGGTATTCAGCTTTCTGCCAATGATATGGTGCGTCCGGGAGACT
GGATCACGCTTCCTTCCGGTGCCGCGAATGGTACGGTGCAGGAGATTACGCTTAACACGGTCAAGATTCAGAACTTTGAT
AATACGATTTCTACGGTTCCGCCTTATACGCTGGTTAGCAGTCCTTTTCAGAACTGGCGTGGCATGAAGGATTCCGGTGG
GCGGCGGGTGATGAAGAATATTACACTGGACCTGACGACACTCCAGTTTTGTACGCCGGAGATGCTCGACCGTTATCGGA
AAGAGATTCCACTCATGGCGGATTATCAGCCGGAGGAAGGAGTGGTGCCCACCAATTCACAGGTTTACCGGGTGTATATC
GAGCGGTATCTTTGCAGTCTGCCGGTGGTGAATCAGGATTTGGATTTGATTATCAGTCAGAAAGAGGCTACCATGTACGG
AGTTCCTATTCAGGTTTATTTCTTTTCCCGCAATAAGGTGTGGAAAGAGTACGAGCGGATTCAGTCGGATATCTTCGACC
ATTTGCTGGCGATGGTGCCGAAGTTCGACTTGAAGGTATACCAGTATTCTGACTAA

Upstream 100 bases:

>100_bases
GTCTTGATTTCTAGTAAATCGGACGCCAGTCTTTTTTTTAAACCAAACGTAGGTTTTCACTGTTATCATTCTATATAAAT
GATATATAAAGAAAGAACTT

Downstream 100 bases:

>100_bases
CTCTATAGGGGACATCTTTGCCACAGGCTTAGCACAACTGTGCCACGCCTGTGGCACGGCCGTGCCAAGCTGTTGGCATA
GTTGTGCCAAAGCGTTGGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLVVDLGKWMNKILIDWGIDAKVADRFDETIIAILMIAIAVGVDYLCQAILVGGMRQYTRRKPHLWNTLLMKRKVFHNLI
HTIPAILVYALLPMAFMRGKELLVISQKACAIYIIFSLLLAINGILLMIMDIYDGKETMKNRPMKGFIQVLQVLLFFIGG
IVIISILVNKSPASLFAGLGASAAILMLVFKDSILGFVAGIQLSANDMVRPGDWITLPSGAANGTVQEITLNTVKIQNFD
NTISTVPPYTLVSSPFQNWRGMKDSGGRRVMKNITLDLTTLQFCTPEMLDRYRKEIPLMADYQPEEGVVPTNSQVYRVYI
ERYLCSLPVVNQDLDLIISQKEATMYGVPIQVYFFSRNKVWKEYERIQSDIFDHLLAMVPKFDLKVYQYSD

Sequences:

>Translated_391_residues
MLVVDLGKWMNKILIDWGIDAKVADRFDETIIAILMIAIAVGVDYLCQAILVGGMRQYTRRKPHLWNTLLMKRKVFHNLI
HTIPAILVYALLPMAFMRGKELLVISQKACAIYIIFSLLLAINGILLMIMDIYDGKETMKNRPMKGFIQVLQVLLFFIGG
IVIISILVNKSPASLFAGLGASAAILMLVFKDSILGFVAGIQLSANDMVRPGDWITLPSGAANGTVQEITLNTVKIQNFD
NTISTVPPYTLVSSPFQNWRGMKDSGGRRVMKNITLDLTTLQFCTPEMLDRYRKEIPLMADYQPEEGVVPTNSQVYRVYI
ERYLCSLPVVNQDLDLIISQKEATMYGVPIQVYFFSRNKVWKEYERIQSDIFDHLLAMVPKFDLKVYQYSD
>Mature_391_residues
MLVVDLGKWMNKILIDWGIDAKVADRFDETIIAILMIAIAVGVDYLCQAILVGGMRQYTRRKPHLWNTLLMKRKVFHNLI
HTIPAILVYALLPMAFMRGKELLVISQKACAIYIIFSLLLAINGILLMIMDIYDGKETMKNRPMKGFIQVLQVLLFFIGG
IVIISILVNKSPASLFAGLGASAAILMLVFKDSILGFVAGIQLSANDMVRPGDWITLPSGAANGTVQEITLNTVKIQNFD
NTISTVPPYTLVSSPFQNWRGMKDSGGRRVMKNITLDLTTLQFCTPEMLDRYRKEIPLMADYQPEEGVVPTNSQVYRVYI
ERYLCSLPVVNQDLDLIISQKEATMYGVPIQVYFFSRNKVWKEYERIQSDIFDHLLAMVPKFDLKVYQYSD

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=355, Percent_Identity=36.6197183098592, Blast_Score=250, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 44310; Mature: 44310

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVDLGKWMNKILIDWGIDAKVADRFDETIIAILMIAIAVGVDYLCQAILVGGMRQYTR
CEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKPHLWNTLLMKRKVFHNLIHTIPAILVYALLPMAFMRGKELLVISQKACAIYIIFSLLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
AINGILLMIMDIYDGKETMKNRPMKGFIQVLQVLLFFIGGIVIISILVNKSPASLFAGLG
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ASAAILMLVFKDSILGFVAGIQLSANDMVRPGDWITLPSGAANGTVQEITLNTVKIQNFD
HHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEECCCCCCCCCEEEEEEEEEEEECCC
NTISTVPPYTLVSSPFQNWRGMKDSGGRRVMKNITLDLTTLQFCTPEMLDRYRKEIPLMA
CCCCCCCCHHHHCCCHHHCCCCCCCCCHHHHHHHEEEEHHHHHCCHHHHHHHHHHCCCEE
DYQPEEGVVPTNSQVYRVYIERYLCSLPVVNQDLDLIISQKEATMYGVPIQVYFFSRNKV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCEEECCEEEEEEECCCHH
WKEYERIQSDIFDHLLAMVPKFDLKVYQYSD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MLVVDLGKWMNKILIDWGIDAKVADRFDETIIAILMIAIAVGVDYLCQAILVGGMRQYTR
CEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKPHLWNTLLMKRKVFHNLIHTIPAILVYALLPMAFMRGKELLVISQKACAIYIIFSLLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
AINGILLMIMDIYDGKETMKNRPMKGFIQVLQVLLFFIGGIVIISILVNKSPASLFAGLG
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ASAAILMLVFKDSILGFVAGIQLSANDMVRPGDWITLPSGAANGTVQEITLNTVKIQNFD
HHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEECCCCCCCCCEEEEEEEEEEEECCC
NTISTVPPYTLVSSPFQNWRGMKDSGGRRVMKNITLDLTTLQFCTPEMLDRYRKEIPLMA
CCCCCCCCHHHHCCCHHHCCCCCCCCCHHHHHHHEEEEHHHHHCCHHHHHHHHHHCCCEE
DYQPEEGVVPTNSQVYRVYIERYLCSLPVVNQDLDLIISQKEATMYGVPIQVYFFSRNKV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCEEECCEEEEEEECCCHH
WKEYERIQSDIFDHLLAMVPKFDLKVYQYSD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]