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The map label for this gene is aslA [H]

Identifier: 29347034

GI number: 29347034

Start: 1999530

End: 2001077

Strand: Reverse

Name: aslA [H]

Synonym: BT_1624

Alternate gene names: 29347034

Gene position: 2001077-1999530 (Counterclockwise)

Preceding gene: 29347035

Following gene: 29347033

Centisome position: 31.96

GC content: 49.74

Gene sequence:

>1548_bases
ATGAGAAAAGAATTTTATGGTATATTACCTTTAGCGTTAACTTCCTGTCTGGCTTCTCAGACCACTGCTCAGGAGAAACA
AACCCAGCGTCCGAATGTTGTTTTTATCTATGCGGATGATATCGGTTACGGCGATTTGAGTTGTAACGGAGCCAAGACTA
TTCATACTCCTAATGTGGAACGTCTTGCCAAAATGGGAGTACGTTTTACCAATGCGCACAGTGCAGCTGCTACCAGTACG
CCTTCCCGCTATGCGATGCTGACCGGTGAATATGCATGGCGCAAAGCCGGAACAGGTATTGCTGCCGGAGACGCTGCGGC
TATTATCCGTCCGGAACGCTATACAATGGCGAACCTGTTCAAGGATGCCGGATACAACACCGGAGTCGTAGGCAAATGGC
ATCTGGGACTGGGCGACAAGGGCGGAGAACAAGACTGGAACAAGCCTTTGCAGCCGGGAACGAATGATATCGGCTTCGAA
TATTCCTTTATCATGGCAGCTACGGGCGACCGTGTTCCTTGTGTATTTGTAGAGAATGATCAGGTGATCAACCTTGATCC
GAATGATCCGATTCAGGTAAGTTACAAAGCGAACTTTCCGGGAGAACCTACCGGGAAGGACAATCCGGAGTTGCTGAAAA
TGCATCCTTCTCACGGACACGACCAGAGTATCGTGAACGGTATTTCCCGTATCGGATATATGAAGGGCGGAAAGTCGGCT
CTCTGGCAGGATGAGAAGATTGCGGAGACGCTGACAGGAAAAGCTGTTTCCTTTATTGAAGGACACAAGTCTGCTCCTTT
CTTCCTGTATTTTGCCACGCAGGATGCGCATGTTCCCCGTGTTCCGTCTCCACAGTTCGCAGGAAAGAGCGGCATGGGAC
CTCGCGGCGATTGTCTGCTCGAATTTGACTGGTCGGTAGGCGAGATTCTGAATGCACTCGAACGACTGGGATTGGATAAG
AATACACTGGTGATTCTTTCCAGTGATAACGGTCCGGTAGTGGACGACGGATATAAGGATCAGGCAGTGGAATTGCTAGG
CGATCATACTCCGGGCGGCATTTATCGCGGAGGAAAGTACAGTTCGTTCGAAGCGGGTACACGTATTCCTTGTATCTGGA
GCTGGCAGGGTGTGATCCGTCCGGGAACAGTTTCGGATGCATTGCTCTGTCAGATAGACTGGTTTGCTACTTTTGCCGAA
ATGCTGAATGTCCGCTTGCCGGAAGGTGCGGCACCGGATAGTGAACCGATGCTGAAAGCGTGGACAGGCAAGCAAAAGAA
GGGACGCGAATGGCTGGTACTTCAGAATGCACAGAATAACCTGTCGGTGACAGACGGAAGATGGAAATATCTTCGTCCGG
GAAATGGACCGGCATATCTGAAAGCAGTGAATATCGAGTTGGGAAACAGTAAGGAACCGCAGCTTTACGATCTGAAGAAA
GATCCGAAAGAAAAGAATAATGTGGCGGGTCAGAATCCGGAACTGGTAAAGAAGATGGCAGCACAGTTGGAGAAAATTGT
AGATGGACGCTACGGTCTGCCACTATAA

Upstream 100 bases:

>100_bases
CCGTAGCTCCTTGACGAAGCTTTGAATTTTAACTTAATAAGTACATCACTTTGAGAATAGATACTTATTCATTCTAACCT
AATAATTATCAAAAGACAAA

Downstream 100 bases:

>100_bases
AAGAAATGCTTAGAGAGTAGCAGTGGGACTGGCGGTCTTGATTTCTAGTAAATCGGACGCCAGTCTTTTTTTTAAACCAA
ACGTAGGTTTTCACTGTTAT

Product: putative secreted sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MRKEFYGILPLALTSCLASQTTAQEKQTQRPNVVFIYADDIGYGDLSCNGAKTIHTPNVERLAKMGVRFTNAHSAAATST
PSRYAMLTGEYAWRKAGTGIAAGDAAAIIRPERYTMANLFKDAGYNTGVVGKWHLGLGDKGGEQDWNKPLQPGTNDIGFE
YSFIMAATGDRVPCVFVENDQVINLDPNDPIQVSYKANFPGEPTGKDNPELLKMHPSHGHDQSIVNGISRIGYMKGGKSA
LWQDEKIAETLTGKAVSFIEGHKSAPFFLYFATQDAHVPRVPSPQFAGKSGMGPRGDCLLEFDWSVGEILNALERLGLDK
NTLVILSSDNGPVVDDGYKDQAVELLGDHTPGGIYRGGKYSSFEAGTRIPCIWSWQGVIRPGTVSDALLCQIDWFATFAE
MLNVRLPEGAAPDSEPMLKAWTGKQKKGREWLVLQNAQNNLSVTDGRWKYLRPGNGPAYLKAVNIELGNSKEPQLYDLKK
DPKEKNNVAGQNPELVKKMAAQLEKIVDGRYGLPL

Sequences:

>Translated_515_residues
MRKEFYGILPLALTSCLASQTTAQEKQTQRPNVVFIYADDIGYGDLSCNGAKTIHTPNVERLAKMGVRFTNAHSAAATST
PSRYAMLTGEYAWRKAGTGIAAGDAAAIIRPERYTMANLFKDAGYNTGVVGKWHLGLGDKGGEQDWNKPLQPGTNDIGFE
YSFIMAATGDRVPCVFVENDQVINLDPNDPIQVSYKANFPGEPTGKDNPELLKMHPSHGHDQSIVNGISRIGYMKGGKSA
LWQDEKIAETLTGKAVSFIEGHKSAPFFLYFATQDAHVPRVPSPQFAGKSGMGPRGDCLLEFDWSVGEILNALERLGLDK
NTLVILSSDNGPVVDDGYKDQAVELLGDHTPGGIYRGGKYSSFEAGTRIPCIWSWQGVIRPGTVSDALLCQIDWFATFAE
MLNVRLPEGAAPDSEPMLKAWTGKQKKGREWLVLQNAQNNLSVTDGRWKYLRPGNGPAYLKAVNIELGNSKEPQLYDLKK
DPKEKNNVAGQNPELVKKMAAQLEKIVDGRYGLPL
>Mature_515_residues
MRKEFYGILPLALTSCLASQTTAQEKQTQRPNVVFIYADDIGYGDLSCNGAKTIHTPNVERLAKMGVRFTNAHSAAATST
PSRYAMLTGEYAWRKAGTGIAAGDAAAIIRPERYTMANLFKDAGYNTGVVGKWHLGLGDKGGEQDWNKPLQPGTNDIGFE
YSFIMAATGDRVPCVFVENDQVINLDPNDPIQVSYKANFPGEPTGKDNPELLKMHPSHGHDQSIVNGISRIGYMKGGKSA
LWQDEKIAETLTGKAVSFIEGHKSAPFFLYFATQDAHVPRVPSPQFAGKSGMGPRGDCLLEFDWSVGEILNALERLGLDK
NTLVILSSDNGPVVDDGYKDQAVELLGDHTPGGIYRGGKYSSFEAGTRIPCIWSWQGVIRPGTVSDALLCQIDWFATFAE
MLNVRLPEGAAPDSEPMLKAWTGKQKKGREWLVLQNAQNNLSVTDGRWKYLRPGNGPAYLKAVNIELGNSKEPQLYDLKK
DPKEKNNVAGQNPELVKKMAAQLEKIVDGRYGLPL

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI53831991, Length=509, Percent_Identity=29.8624754420432, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI146229331, Length=485, Percent_Identity=30.1030927835052, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI146229329, Length=485, Percent_Identity=30.1030927835052, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI6005990, Length=485, Percent_Identity=30.1030927835052, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI146229324, Length=485, Percent_Identity=30.1030927835052, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI71852584, Length=531, Percent_Identity=27.683615819209, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI58743319, Length=520, Percent_Identity=26.3461538461538, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI157266309, Length=559, Percent_Identity=26.1180679785331, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI31742482, Length=576, Percent_Identity=26.2152777777778, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI45430057, Length=531, Percent_Identity=28.2485875706215, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4503899, Length=487, Percent_Identity=27.5154004106776, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI71852586, Length=316, Percent_Identity=29.746835443038, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI146229327, Length=403, Percent_Identity=28.0397022332506, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI109389362, Length=531, Percent_Identity=23.728813559322, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI38569407, Length=409, Percent_Identity=24.6943765281174, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI59797060, Length=117, Percent_Identity=37.6068376068376, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38569405, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790233, Length=411, Percent_Identity=27.4939172749392, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87081924, Length=296, Percent_Identity=23.9864864864865, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790112, Length=116, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=505, Percent_Identity=24.7524752475248, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=492, Percent_Identity=23.9837398373984, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=147, Percent_Identity=34.6938775510204, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24666175, Length=587, Percent_Identity=25.8943781942078, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281363223, Length=406, Percent_Identity=24.8768472906404, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281366397, Length=117, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281366395, Length=117, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666163, Length=117, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666109, Length=143, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 56356; Mature: 56356

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKEFYGILPLALTSCLASQTTAQEKQTQRPNVVFIYADDIGYGDLSCNGAKTIHTPNVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEECCCCHH
RLAKMGVRFTNAHSAAATSTPSRYAMLTGEYAWRKAGTGIAAGDAAAIIRPERYTMANLF
HHHHHCCEEECCCCCCCCCCCCEEEEEECCHHHHHCCCCEECCCCEEEECCCHHHHHHHH
KDAGYNTGVVGKWHLGLGDKGGEQDWNKPLQPGTNDIGFEYSFIMAATGDRVPCVFVEND
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCC
QVINLDPNDPIQVSYKANFPGEPTGKDNPELLKMHPSHGHDQSIVNGISRIGYMKGGKSA
EEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
LWQDEKIAETLTGKAVSFIEGHKSAPFFLYFATQDAHVPRVPSPQFAGKSGMGPRGDCLL
CCCCHHHHHHHHCCCEEEHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE
EFDWSVGEILNALERLGLDKNTLVILSSDNGPVVDDGYKDQAVELLGDHTPGGIYRGGKY
EECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
SSFEAGTRIPCIWSWQGVIRPGTVSDALLCQIDWFATFAEMLNVRLPEGAAPDSEPMLKA
CCCCCCCCCCEEEECCCEECCCCCCCEEEEEEHHHHHHHHHHCEECCCCCCCCCCCHHHH
WTGKQKKGREWLVLQNAQNNLSVTDGRWKYLRPGNGPAYLKAVNIELGNSKEPQLYDLKK
HCCCCCCCCEEEEEECCCCCCEEECCCEEEECCCCCCEEEEEEEEEECCCCCCCEECCCC
DPKEKNNVAGQNPELVKKMAAQLEKIVDGRYGLPL
CCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRKEFYGILPLALTSCLASQTTAQEKQTQRPNVVFIYADDIGYGDLSCNGAKTIHTPNVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEECCCCHH
RLAKMGVRFTNAHSAAATSTPSRYAMLTGEYAWRKAGTGIAAGDAAAIIRPERYTMANLF
HHHHHCCEEECCCCCCCCCCCCEEEEEECCHHHHHCCCCEECCCCEEEECCCHHHHHHHH
KDAGYNTGVVGKWHLGLGDKGGEQDWNKPLQPGTNDIGFEYSFIMAATGDRVPCVFVEND
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCC
QVINLDPNDPIQVSYKANFPGEPTGKDNPELLKMHPSHGHDQSIVNGISRIGYMKGGKSA
EEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
LWQDEKIAETLTGKAVSFIEGHKSAPFFLYFATQDAHVPRVPSPQFAGKSGMGPRGDCLL
CCCCHHHHHHHHCCCEEEHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE
EFDWSVGEILNALERLGLDKNTLVILSSDNGPVVDDGYKDQAVELLGDHTPGGIYRGGKY
EECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
SSFEAGTRIPCIWSWQGVIRPGTVSDALLCQIDWFATFAEMLNVRLPEGAAPDSEPMLKA
CCCCCCCCCCEEEECCCEECCCCCCCEEEEEEHHHHHHHHHHCEECCCCCCCCCCCHHHH
WTGKQKKGREWLVLQNAQNNLSVTDGRWKYLRPGNGPAYLKAVNIELGNSKEPQLYDLKK
HCCCCCCCCEEEEEECCCCCCEEECCCEEEECCCCCCEEEEEEEEEECCCCCCCEECCCC
DPKEKNNVAGQNPELVKKMAAQLEKIVDGRYGLPL
CCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]