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The map label for this gene is macA [H]

Identifier: 29346877

GI number: 29346877

Start: 1807208

End: 1808455

Strand: Reverse

Name: macA [H]

Synonym: BT_1467

Alternate gene names: 29346877

Gene position: 1808455-1807208 (Counterclockwise)

Preceding gene: 29346878

Following gene: 29346876

Centisome position: 28.89

GC content: 47.84

Gene sequence:

>1248_bases
ATGGATACACCTGTTGAACGCAAACCCGGCATAAATCGCAAACACCTTTATACGATCGGTGGTGTGGCGCTGGGAATCGC
TGTCATTTTATATTTTATTTTTAGAGATACGGCTTCCTCCATGACAGTTGAGAAAGACCGTCTCACGATTGCTACCGTCA
AGCAAGCGGAGTTCAATGATTATATCCGTGTGATCGGGCAAGTGATGCCCAGCCGGATTATCTATATGGATGCCATAGAA
GGCGGTCGTGTGGAAGAACGTTTGAAAGAAGAAGGAGCTATGGTGAAAGCGGGCGATGTGATTCTGCGTCTCAGCAACCC
GTTGCTGAATATCGGAATCATGCAGAGTGAGGCAGACCTTGCCTATCAGGAAAATGAATTGCGCAATACCCGCATCAGTA
TGGAGCAGGAGCGTCTGCAACTGAAACAGGAACGCATAGGCTTGAATAAAGAACTTACATTGAAAAAACGCCGTTATGAA
CAATACAGACGTTTGGTGGAGGAGCAACTGATTGCCCGCGAGGATTTTCGTCAGGCAGAGGAGGAGTATGAAGCTGCCAA
AGAACAACTGGCGGTCATTGACGAACGTATCCGTCAGGATAATATTTTCCGTGAAAGCCAGATCAGCAGTCTGGACGAGA
ACATACGCAACATGAAACGCAGTCTTACGTTGGTCCGTGAGCGCTTGGAAAACCTGAAGATTAAAGCTCCGATTGACGGA
CAGGTAGGAAACTTGAATGCGCAGGTCGGACAGTCCATTTCCGCAGGAGAACATATCGGCCAGATTATTACTCCGGACCT
CAAAGTACAGGCACAGATAGACGAGCATTATGTGGAGCGTGTACTTCCCGGACTTCCTGCCGACTTTACCCGTGACGGAG
GAACCTATAAACTGGAAGTAACCAAACCTTATCCGGAAGTGAAAGAAGGGCAGTTCCGTACTGACCTGGCTTTCATTTCG
GAGCGGCCGGAGAATATACGTGCCGGACAAACTTATCATATCAACCTTCAGTTAGGAGACCCGGCACAAGCGATCCTTGT
TCCCCGTGGCGGATTCTTTCAAATTACCGGAGGGCGGTGGATGTATATTGTCGATGAAAGTGGTAAATTTGCCACGCGGC
GTCCTGTGAAGATCGGGCGCCAGAATCCACAGTATTATGAGGTGACGGAAGGTTTGTCTTCGGGTGAGAAAGTAATCATA
TCCGGTTATGAGTTGTTCGGAGACAATGAGAAACTAATACTAAAATAA

Upstream 100 bases:

>100_bases
GAAACTGGAGAAATACTATCGGGAGGGGACTTTCCTGTAAAACGGAGTCTGTGCCATCGGAACAATCATTTAATAACAAC
CCTATTTTGAATATACCTTT

Downstream 100 bases:

>100_bases
ATAAAAAGAATCACCATGATTAAAACAGAAAAACTGTCTATGCTTTTCACTACGGAAGAGGTGCAGACGAAAGCATTGAA
CGAAGTCACCTTACACGTAG

Product: ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDTPVERKPGINRKHLYTIGGVALGIAVILYFIFRDTASSMTVEKDRLTIATVKQAEFNDYIRVIGQVMPSRIIYMDAIE
GGRVEERLKEEGAMVKAGDVILRLSNPLLNIGIMQSEADLAYQENELRNTRISMEQERLQLKQERIGLNKELTLKKRRYE
QYRRLVEEQLIAREDFRQAEEEYEAAKEQLAVIDERIRQDNIFRESQISSLDENIRNMKRSLTLVRERLENLKIKAPIDG
QVGNLNAQVGQSISAGEHIGQIITPDLKVQAQIDEHYVERVLPGLPADFTRDGGTYKLEVTKPYPEVKEGQFRTDLAFIS
ERPENIRAGQTYHINLQLGDPAQAILVPRGGFFQITGGRWMYIVDESGKFATRRPVKIGRQNPQYYEVTEGLSSGEKVII
SGYELFGDNEKLILK

Sequences:

>Translated_415_residues
MDTPVERKPGINRKHLYTIGGVALGIAVILYFIFRDTASSMTVEKDRLTIATVKQAEFNDYIRVIGQVMPSRIIYMDAIE
GGRVEERLKEEGAMVKAGDVILRLSNPLLNIGIMQSEADLAYQENELRNTRISMEQERLQLKQERIGLNKELTLKKRRYE
QYRRLVEEQLIAREDFRQAEEEYEAAKEQLAVIDERIRQDNIFRESQISSLDENIRNMKRSLTLVRERLENLKIKAPIDG
QVGNLNAQVGQSISAGEHIGQIITPDLKVQAQIDEHYVERVLPGLPADFTRDGGTYKLEVTKPYPEVKEGQFRTDLAFIS
ERPENIRAGQTYHINLQLGDPAQAILVPRGGFFQITGGRWMYIVDESGKFATRRPVKIGRQNPQYYEVTEGLSSGEKVII
SGYELFGDNEKLILK
>Mature_415_residues
MDTPVERKPGINRKHLYTIGGVALGIAVILYFIFRDTASSMTVEKDRLTIATVKQAEFNDYIRVIGQVMPSRIIYMDAIE
GGRVEERLKEEGAMVKAGDVILRLSNPLLNIGIMQSEADLAYQENELRNTRISMEQERLQLKQERIGLNKELTLKKRRYE
QYRRLVEEQLIAREDFRQAEEEYEAAKEQLAVIDERIRQDNIFRESQISSLDENIRNMKRSLTLVRERLENLKIKAPIDG
QVGNLNAQVGQSISAGEHIGQIITPDLKVQAQIDEHYVERVLPGLPADFTRDGGTYKLEVTKPYPEVKEGQFRTDLAFIS
ERPENIRAGQTYHINLQLGDPAQAILVPRGGFFQITGGRWMYIVDESGKFATRRPVKIGRQNPQYYEVTEGLSSGEKVII
SGYELFGDNEKLILK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=289, Percent_Identity=23.8754325259516, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 47445; Mature: 47445

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPVERKPGINRKHLYTIGGVALGIAVILYFIFRDTASSMTVEKDRLTIATVKQAEFND
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECHHHHHH
YIRVIGQVMPSRIIYMDAIEGGRVEERLKEEGAMVKAGDVILRLSNPLLNIGIMQSEADL
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEECCEEEEECCCEEEEEEEECCCCH
AYQENELRNTRISMEQERLQLKQERIGLNKELTLKKRRYEQYRRLVEEQLIAREDFRQAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYEAAKEQLAVIDERIRQDNIFRESQISSLDENIRNMKRSLTLVRERLENLKIKAPIDG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
QVGNLNAQVGQSISAGEHIGQIITPDLKVQAQIDEHYVERVLPGLPADFTRDGGTYKLEV
CCCCCCHHHCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
TKPYPEVKEGQFRTDLAFISERPENIRAGQTYHINLQLGDPAQAILVPRGGFFQITGGRW
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEECCEE
MYIVDESGKFATRRPVKIGRQNPQYYEVTEGLSSGEKVIISGYELFGDNEKLILK
EEEEECCCCCCCCCCHHCCCCCCCEEEHHCCCCCCCEEEEEEEEEECCCCEEEEC
>Mature Secondary Structure
MDTPVERKPGINRKHLYTIGGVALGIAVILYFIFRDTASSMTVEKDRLTIATVKQAEFND
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECHHHHHH
YIRVIGQVMPSRIIYMDAIEGGRVEERLKEEGAMVKAGDVILRLSNPLLNIGIMQSEADL
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEECCEEEEECCCEEEEEEEECCCCH
AYQENELRNTRISMEQERLQLKQERIGLNKELTLKKRRYEQYRRLVEEQLIAREDFRQAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYEAAKEQLAVIDERIRQDNIFRESQISSLDENIRNMKRSLTLVRERLENLKIKAPIDG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
QVGNLNAQVGQSISAGEHIGQIITPDLKVQAQIDEHYVERVLPGLPADFTRDGGTYKLEV
CCCCCCHHHCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
TKPYPEVKEGQFRTDLAFISERPENIRAGQTYHINLQLGDPAQAILVPRGGFFQITGGRW
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEECCEE
MYIVDESGKFATRRPVKIGRQNPQYYEVTEGLSSGEKVIISGYELFGDNEKLILK
EEEEECCCCCCCCCCHHCCCCCCCEEEHHCCCCCCCEEEEEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]