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The map label for this gene is pccB [H]

Identifier: 29346860

GI number: 29346860

Start: 1785763

End: 1787307

Strand: Reverse

Name: pccB [H]

Synonym: BT_1450

Alternate gene names: 29346860

Gene position: 1787307-1785763 (Counterclockwise)

Preceding gene: 29346864

Following gene: 29346859

Centisome position: 28.55

GC content: 49.71

Gene sequence:

>1545_bases
ATGAAAGAGCTTATCAAGAATCTGGAAGAACTGAACAGGAAAGCAGAAAAAGGTGGCGGGGATGCCCGTATTGAGAAACA
GCACTCTGTGGGCAAGCTGACCGCCCGTGAACGCATTGACTTACTTCTGGAAAAAGGGTCGTTTATCGAACTTGATAAAC
TGGTAACCCACCGGTGTACTGACTTTGGTATGGAAAAACAGAAATTCTCCGGTGACGGGGTAGTGACTGGTTACGGAATG
ATTGGCAAACGGCTGGTCTATGTTTTTGCACAGGACTTCACCGTATTCGGAGGGGCTCTTTCGGAGACACACGCCAAGAA
GATTTGCAAAGTGATGGACATGGCGATGCAGATGGGAGCGCCTATTATCGGACTCAATGATTCCGGTGGTGCGCGCATTC
AGGAAGGTGTCCGTTCTTTGGCAGGATATGCGGAGATTTTCCTTCGCAATTCCATGGCTTCGGGAGTCATTCCGCAGATC
AGTGCTATCATGGGTCCGTGTGCCGGTGGTGCCGTTTATTCTCCTGCACTGACCGATTTTATTCTGATGGTCAAGAACTC
CGGCTATATGTTTATCACCGGACCGGACGTAGTCAAGAGTGTGACACAGGAAGAAGTAAGCAAGGAAGATCTGGGTGGAG
TGGGCATCCACATGACAAAGTCCGGCGTGGCGCATCTATCGGCCGAAAATGATATTGAATGTATCAATTATATCCGCGAA
CTTATTTCTTATCTGCCGGGCAACAATATGGAAGAGCCTCCTTTCGTTGTCACCAACGACTCGCCGACCCGCCTGACACC
CGAACTGTCCGACTTGGTGCCTACCAATCCGAATCAGCCCTATAATATAAAGGAGATGATAGAAGCGGTGGCCGACGATA
ATAACTTCTTTGAACTTCAGGCAGAATTTGCCGCGAACATCGTTACCGGATATATCCGTCTGAACGGAAAGACGATAGGG
GTGGTAGCCAATCAGCCGCTGGTGCTGGCAGGAACACTGGACATCAATGCCTCTATAAAGGCTGCCCGTTTCGTTCGCTT
CTGCGATGCTTTCAATATACCTTTGCTGACTCTGGTCGATGTTCCGGGATTCCTTCCGGGAGTAGATCAGGAATATGGCG
GAATCATCCGTAATGGTGCGAAACTGCTTTACGCTTACTGCGAAGCTACCGTGCCGAAAGTGACCGTTATCACCCGTAAG
GCTTACGGAGGCGCTTATGATGTGATGAGTTCCAAGCATATCCGTGGCGATGTCAATCTGGCTTTCCCCACTGCCGAAAT
CGCTGTGATGGGACCGGACGGGGCCGTAAATATCCTATTCAAGAAAGAGATCGAAAAGTCACAGACTCCCGAAGAAAGGC
GAAAGGAACTTCAGAGCGATTATCGTGAAAAGTTTGCCAATCCTTACCGCGCAGCGGAACTGGGCTATGTGGATGAAGTG
ATCGATCCGGCCGTTACCCGTTTGCGCCTGATACGCAGTTTCGAAATGCTGGCCAATAAACGTCAGTCCAATCCGCCTAA
GAAACACTCGAACATTCCACTTTAA

Upstream 100 bases:

>100_bases
TGATACGTTTACTATATAAAAATACCTTTGTGTAATCAATATGACAACTAATTAATTTATTACTGACTATTTTTACACAT
AACATTAATACAAACAGCCT

Downstream 100 bases:

>100_bases
TAAATGGAAAATGGAAAGTTGAAAATGGAGAGTGATAAATTAAAAGAAACAGATTATGATAAAGAAAATATTAGTTGCTA
ATCGTGGAGAGATAGCTATG

Product: propionyl-CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKELIKNLEELNRKAEKGGGDARIEKQHSVGKLTARERIDLLLEKGSFIELDKLVTHRCTDFGMEKQKFSGDGVVTGYGM
IGKRLVYVFAQDFTVFGGALSETHAKKICKVMDMAMQMGAPIIGLNDSGGARIQEGVRSLAGYAEIFLRNSMASGVIPQI
SAIMGPCAGGAVYSPALTDFILMVKNSGYMFITGPDVVKSVTQEEVSKEDLGGVGIHMTKSGVAHLSAENDIECINYIRE
LISYLPGNNMEEPPFVVTNDSPTRLTPELSDLVPTNPNQPYNIKEMIEAVADDNNFFELQAEFAANIVTGYIRLNGKTIG
VVANQPLVLAGTLDINASIKAARFVRFCDAFNIPLLTLVDVPGFLPGVDQEYGGIIRNGAKLLYAYCEATVPKVTVITRK
AYGGAYDVMSSKHIRGDVNLAFPTAEIAVMGPDGAVNILFKKEIEKSQTPEERRKELQSDYREKFANPYRAAELGYVDEV
IDPAVTRLRLIRSFEMLANKRQSNPPKKHSNIPL

Sequences:

>Translated_514_residues
MKELIKNLEELNRKAEKGGGDARIEKQHSVGKLTARERIDLLLEKGSFIELDKLVTHRCTDFGMEKQKFSGDGVVTGYGM
IGKRLVYVFAQDFTVFGGALSETHAKKICKVMDMAMQMGAPIIGLNDSGGARIQEGVRSLAGYAEIFLRNSMASGVIPQI
SAIMGPCAGGAVYSPALTDFILMVKNSGYMFITGPDVVKSVTQEEVSKEDLGGVGIHMTKSGVAHLSAENDIECINYIRE
LISYLPGNNMEEPPFVVTNDSPTRLTPELSDLVPTNPNQPYNIKEMIEAVADDNNFFELQAEFAANIVTGYIRLNGKTIG
VVANQPLVLAGTLDINASIKAARFVRFCDAFNIPLLTLVDVPGFLPGVDQEYGGIIRNGAKLLYAYCEATVPKVTVITRK
AYGGAYDVMSSKHIRGDVNLAFPTAEIAVMGPDGAVNILFKKEIEKSQTPEERRKELQSDYREKFANPYRAAELGYVDEV
IDPAVTRLRLIRSFEMLANKRQSNPPKKHSNIPL
>Mature_514_residues
MKELIKNLEELNRKAEKGGGDARIEKQHSVGKLTARERIDLLLEKGSFIELDKLVTHRCTDFGMEKQKFSGDGVVTGYGM
IGKRLVYVFAQDFTVFGGALSETHAKKICKVMDMAMQMGAPIIGLNDSGGARIQEGVRSLAGYAEIFLRNSMASGVIPQI
SAIMGPCAGGAVYSPALTDFILMVKNSGYMFITGPDVVKSVTQEEVSKEDLGGVGIHMTKSGVAHLSAENDIECINYIRE
LISYLPGNNMEEPPFVVTNDSPTRLTPELSDLVPTNPNQPYNIKEMIEAVADDNNFFELQAEFAANIVTGYIRLNGKTIG
VVANQPLVLAGTLDINASIKAARFVRFCDAFNIPLLTLVDVPGFLPGVDQEYGGIIRNGAKLLYAYCEATVPKVTVITRK
AYGGAYDVMSSKHIRGDVNLAFPTAEIAVMGPDGAVNILFKKEIEKSQTPEERRKELQSDYREKFANPYRAAELGYVDEV
IDPAVTRLRLIRSFEMLANKRQSNPPKKHSNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=61.4481409001957, Blast_Score=650, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=59.1337099811676, Blast_Score=638, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=33.7209302325581, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=395, Percent_Identity=26.3291139240506, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=58.974358974359, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=58.974358974359, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=513, Percent_Identity=33.3333333333333, Blast_Score=265, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI71997163, Length=393, Percent_Identity=25.1908396946565, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133931226, Length=308, Percent_Identity=24.6753246753247, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323863, Length=351, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324343, Length=376, Percent_Identity=24.7340425531915, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586065, Length=529, Percent_Identity=32.8922495274102, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24586458, Length=341, Percent_Identity=24.9266862170088, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076407, Length=341, Percent_Identity=24.9266862170088, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586460, Length=341, Percent_Identity=24.9266862170088, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076409, Length=341, Percent_Identity=24.9266862170088, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56329; Mature: 56329

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELIKNLEELNRKAEKGGGDARIEKQHSVGKLTARERIDLLLEKGSFIELDKLVTHRCT
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
DFGMEKQKFSGDGVVTGYGMIGKRLVYVFAQDFTVFGGALSETHAKKICKVMDMAMQMGA
HCCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
PIIGLNDSGGARIQEGVRSLAGYAEIFLRNSMASGVIPQISAIMGPCAGGAVYSPALTDF
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHE
ILMVKNSGYMFITGPDVVKSVTQEEVSKEDLGGVGIHMTKSGVAHLSAENDIECINYIRE
EEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCHHHHHHHHH
LISYLPGNNMEEPPFVVTNDSPTRLTPELSDLVPTNPNQPYNIKEMIEAVADDNNFFELQ
HHHHCCCCCCCCCCEEEECCCCCEECCCHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
AEFAANIVTGYIRLNGKTIGVVANQPLVLAGTLDINASIKAARFVRFCDAFNIPLLTLVD
HHHHHCEEEEEEEECCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGVDQEYGGIIRNGAKLLYAYCEATVPKVTVITRKAYGGAYDVMSSKHIRGDVNL
CCCCCCCCCCHHCHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCEEE
AFPTAEIAVMGPDGAVNILFKKEIEKSQTPEERRKELQSDYREKFANPYRAAELGYVDEV
EECCEEEEEECCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
IDPAVTRLRLIRSFEMLANKRQSNPPKKHSNIPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKELIKNLEELNRKAEKGGGDARIEKQHSVGKLTARERIDLLLEKGSFIELDKLVTHRCT
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
DFGMEKQKFSGDGVVTGYGMIGKRLVYVFAQDFTVFGGALSETHAKKICKVMDMAMQMGA
HCCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
PIIGLNDSGGARIQEGVRSLAGYAEIFLRNSMASGVIPQISAIMGPCAGGAVYSPALTDF
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHE
ILMVKNSGYMFITGPDVVKSVTQEEVSKEDLGGVGIHMTKSGVAHLSAENDIECINYIRE
EEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCHHHHHHHHH
LISYLPGNNMEEPPFVVTNDSPTRLTPELSDLVPTNPNQPYNIKEMIEAVADDNNFFELQ
HHHHCCCCCCCCCCEEEECCCCCEECCCHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
AEFAANIVTGYIRLNGKTIGVVANQPLVLAGTLDINASIKAARFVRFCDAFNIPLLTLVD
HHHHHCEEEEEEEECCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGVDQEYGGIIRNGAKLLYAYCEATVPKVTVITRKAYGGAYDVMSSKHIRGDVNL
CCCCCCCCCCHHCHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCEEE
AFPTAEIAVMGPDGAVNILFKKEIEKSQTPEERRKELQSDYREKFANPYRAAELGYVDEV
EECCEEEEEECCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
IDPAVTRLRLIRSFEMLANKRQSNPPKKHSNIPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]