Click here to switch to the map view.

The map label for this gene is accC1 [H]

Identifier: 29346859

GI number: 29346859

Start: 1784196

End: 1785707

Strand: Reverse

Name: accC1 [H]

Synonym: BT_1449

Alternate gene names: 29346859

Gene position: 1785707-1784196 (Counterclockwise)

Preceding gene: 29346860

Following gene: 29346858

Centisome position: 28.52

GC content: 50.2

Gene sequence:

>1512_bases
ATGATAAAGAAAATATTAGTTGCTAATCGTGGAGAGATAGCTATGCGCATCTTCCGTACTTGTCGGGTGATGGATATTTC
GACGGTGGCTGTTTACACGCATGTAGACAGGGGGGCTTTGCATGTTCGCTATGCGGAGGAGGCTTATTGCATCTCCAATT
CGCCGGAGGATACTTCTTATTTGAAGCCGGAGTTGATACTGGCCATTGCCAAAAAGACCGGAGCCGCCATTCATCCGGGA
TATGGGTTCTTGTCGGAGAACGCTGACTTTGCCCGTCGTTGCGAAGAAGAAGGAGTGATCTTTATCGGGCCCGGTGCCGA
TATTATTGCTAAGATGGGGATCAAGACTGAGGCACGCAAAATCATGCGTGAAGCGGGGCTGCCCATCGTTCCCGGAACGG
AAACTCCCGTACAGGGGATCGAAGAAGTGAAGAAGGTTGCTAAGGAAGTAGGTTATCCTATTATGTTGAAAGCGCTTGCC
GGAGGAGGCGGAAAGGGGATGCGTCTGGTCCGTTCCGAAGAAGAAGCGGAAACGGCTCTTCGTTTGTCTCAGTCCGAGGC
GGGTACTTCTTTTGGTAATGATGCGGTCTATATAGAGAAATATATCGAGAATCCGCACCATATCGAGGTGCAGATTATGG
GAGATAAATATGGCAATGTGGTTCATCTGGGCGAGCGTGAATGTTCCATTCAGCGACGTAATCAGAAGGTAATCGAGGAG
TCTCCGTCACCGTTTGTGAAAGACGAAACCCGTAAGAAGATGCTGAAAGTAGCCGTAGAGGCTTGCAAGCGGATCGGTTA
TTACAGTGCCGGCACGCTGGAGTTCATGATGGATAAAGACCAGAACTTCTATTTCCTTGAAATGAATACCCGTTTGCAGG
TAGAACATCCGGTGACGGAGGAATGTACCGGCGTCGATCTGGTGCGTGACATGATCACGGTGGCTGCGGGCAATCCGTTG
CCGTATAAGCAGGAAGATATAAAATTCAGCGGAGCTGCCATCGAATGCCGTATCTACGCCGAAGATCCGGAGAATAACTT
TATGCCTTCTCCCGGAGTGATAACTGTTCGTGAAGCTCCCGAAGGCCGTAACCTCCGTCTGGACAGTGCCGCCTATGCCG
GATTCGAAGTTTCACTGCATTATGATCCGATGATTGCCAAGCTCTGCTGCTGGGGGCGTACCCGTGAATCCGCCATCTCC
AACATGGCACGTGCCTTGCGTGAGTATAAGATTCTGGGCATCAAGACGACGATTCCTTTCCATCAGCGTGTGTTGAAGAA
TGCCGCTTTCCTCGAAGGAAAATATGATACGACTTTTATCGATACCCGTTTTGACAAGGAGGACTTGAAGCGTCGTCAGA
ATACTGATCCGACTGTTGCCGTGATCGCTGCCGCCGTAAGGCATTACGAGAGGGAGAAAGAAGCTGCATCCCGTGCCACC
ACGCTCCCTGTAGTGGGCGAATCTCTCTGGAAGTATTATGGCAAGTTGCAGATGACTGCCAATAATTATTGA

Upstream 100 bases:

>100_bases
CGTCAGTCCAATCCGCCTAAGAAACACTCGAACATTCCACTTTAATAAATGGAAAATGGAAAGTTGAAAATGGAGAGTGA
TAAATTAAAAGAAACAGATT

Downstream 100 bases:

>100_bases
ATAAGTGGAGAGTTGAGAGTTGAAAATTGAAAGTTAAGTTGGTCATTCATTAAAATTAGAAAGATATGGGTACATCGTTA
GCGACTTATTATGCCAAGCT

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MIKKILVANRGEIAMRIFRTCRVMDISTVAVYTHVDRGALHVRYAEEAYCISNSPEDTSYLKPELILAIAKKTGAAIHPG
YGFLSENADFARRCEEEGVIFIGPGADIIAKMGIKTEARKIMREAGLPIVPGTETPVQGIEEVKKVAKEVGYPIMLKALA
GGGGKGMRLVRSEEEAETALRLSQSEAGTSFGNDAVYIEKYIENPHHIEVQIMGDKYGNVVHLGERECSIQRRNQKVIEE
SPSPFVKDETRKKMLKVAVEACKRIGYYSAGTLEFMMDKDQNFYFLEMNTRLQVEHPVTEECTGVDLVRDMITVAAGNPL
PYKQEDIKFSGAAIECRIYAEDPENNFMPSPGVITVREAPEGRNLRLDSAAYAGFEVSLHYDPMIAKLCCWGRTRESAIS
NMARALREYKILGIKTTIPFHQRVLKNAAFLEGKYDTTFIDTRFDKEDLKRRQNTDPTVAVIAAAVRHYEREKEAASRAT
TLPVVGESLWKYYGKLQMTANNY

Sequences:

>Translated_503_residues
MIKKILVANRGEIAMRIFRTCRVMDISTVAVYTHVDRGALHVRYAEEAYCISNSPEDTSYLKPELILAIAKKTGAAIHPG
YGFLSENADFARRCEEEGVIFIGPGADIIAKMGIKTEARKIMREAGLPIVPGTETPVQGIEEVKKVAKEVGYPIMLKALA
GGGGKGMRLVRSEEEAETALRLSQSEAGTSFGNDAVYIEKYIENPHHIEVQIMGDKYGNVVHLGERECSIQRRNQKVIEE
SPSPFVKDETRKKMLKVAVEACKRIGYYSAGTLEFMMDKDQNFYFLEMNTRLQVEHPVTEECTGVDLVRDMITVAAGNPL
PYKQEDIKFSGAAIECRIYAEDPENNFMPSPGVITVREAPEGRNLRLDSAAYAGFEVSLHYDPMIAKLCCWGRTRESAIS
NMARALREYKILGIKTTIPFHQRVLKNAAFLEGKYDTTFIDTRFDKEDLKRRQNTDPTVAVIAAAVRHYEREKEAASRAT
TLPVVGESLWKYYGKLQMTANNY
>Mature_503_residues
MIKKILVANRGEIAMRIFRTCRVMDISTVAVYTHVDRGALHVRYAEEAYCISNSPEDTSYLKPELILAIAKKTGAAIHPG
YGFLSENADFARRCEEEGVIFIGPGADIIAKMGIKTEARKIMREAGLPIVPGTETPVQGIEEVKKVAKEVGYPIMLKALA
GGGGKGMRLVRSEEEAETALRLSQSEAGTSFGNDAVYIEKYIENPHHIEVQIMGDKYGNVVHLGERECSIQRRNQKVIEE
SPSPFVKDETRKKMLKVAVEACKRIGYYSAGTLEFMMDKDQNFYFLEMNTRLQVEHPVTEECTGVDLVRDMITVAAGNPL
PYKQEDIKFSGAAIECRIYAEDPENNFMPSPGVITVREAPEGRNLRLDSAAYAGFEVSLHYDPMIAKLCCWGRTRESAIS
NMARALREYKILGIKTTIPFHQRVLKNAAFLEGKYDTTFIDTRFDKEDLKRRQNTDPTVAVIAAAVRHYEREKEAASRAT
TLPVVGESLWKYYGKLQMTANNY

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=453, Percent_Identity=48.7858719646799, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI189095269, Length=502, Percent_Identity=45.8167330677291, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI65506442, Length=502, Percent_Identity=45.8167330677291, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI295821183, Length=502, Percent_Identity=45.8167330677291, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI106049528, Length=459, Percent_Identity=47.4945533769063, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=459, Percent_Identity=47.4945533769063, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=459, Percent_Identity=47.4945533769063, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.2992125984252, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.2992125984252, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.2992125984252, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.2992125984252, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.2992125984252, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.8447937131631, Blast_Score=230, Evalue=3e-60,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=47.9820627802691, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=49.2063492063492, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=48.4090909090909, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=459, Percent_Identity=45.9694989106754, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI133931226, Length=550, Percent_Identity=30.1818181818182, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=537, Percent_Identity=27.9329608938547, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=537, Percent_Identity=27.9329608938547, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=43.018018018018, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=45.9641255605381, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.9798657718121, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324343, Length=555, Percent_Identity=30.2702702702703, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=513, Percent_Identity=29.8245614035088, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=46.5324384787472, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=49.7757847533632, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=46.2102689486553, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=31.1507936507937, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=31.1507936507937, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=31.1507936507937, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=31.1507936507937, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 56394; Mature: 56394

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKILVANRGEIAMRIFRTCRVMDISTVAVYTHVDRGALHVRYAEEAYCISNSPEDTSY
CCCEEEECCCCHHHHHHHHHHHEEEEEEEEEEEECCCCEEEEEECCCEEEECCCCCCCHH
LKPELILAIAKKTGAAIHPGYGFLSENADFARRCEEEGVIFIGPGADIIAKMGIKTEARK
CCHHHEEEEHHHCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCCHHHHH
IMREAGLPIVPGTETPVQGIEEVKKVAKEVGYPIMLKALAGGGGKGMRLVRSEEEAETAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHHH
RLSQSEAGTSFGNDAVYIEKYIENPHHIEVQIMGDKYGNVVHLGERECSIQRRNQKVIEE
HHHHHHCCCCCCCCEEEEEHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHC
SPSPFVKDETRKKMLKVAVEACKRIGYYSAGTLEFMMDKDQNFYFLEMNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCCC
ECTGVDLVRDMITVAAGNPLPYKQEDIKFSGAAIECRIYAEDPENNFMPSPGVITVREAP
CCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEEEEECCCCCCCCCCCEEEEEECC
EGRNLRLDSAAYAGFEVSLHYDPMIAKLCCWGRTRESAISNMARALREYKILGIKTTIPF
CCCCEEECCCEECCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEECCHH
HQRVLKNAAFLEGKYDTTFIDTRFDKEDLKRRQNTDPTVAVIAAAVRHYEREKEAASRAT
HHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TLPVVGESLWKYYGKLQMTANNY
CCHHHHHHHHHHHCEEEEEECCC
>Mature Secondary Structure
MIKKILVANRGEIAMRIFRTCRVMDISTVAVYTHVDRGALHVRYAEEAYCISNSPEDTSY
CCCEEEECCCCHHHHHHHHHHHEEEEEEEEEEEECCCCEEEEEECCCEEEECCCCCCCHH
LKPELILAIAKKTGAAIHPGYGFLSENADFARRCEEEGVIFIGPGADIIAKMGIKTEARK
CCHHHEEEEHHHCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCCHHHHH
IMREAGLPIVPGTETPVQGIEEVKKVAKEVGYPIMLKALAGGGGKGMRLVRSEEEAETAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHHH
RLSQSEAGTSFGNDAVYIEKYIENPHHIEVQIMGDKYGNVVHLGERECSIQRRNQKVIEE
HHHHHHCCCCCCCCEEEEEHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHC
SPSPFVKDETRKKMLKVAVEACKRIGYYSAGTLEFMMDKDQNFYFLEMNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCCC
ECTGVDLVRDMITVAAGNPLPYKQEDIKFSGAAIECRIYAEDPENNFMPSPGVITVREAP
CCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEEEEECCCCCCCCCCCEEEEEECC
EGRNLRLDSAAYAGFEVSLHYDPMIAKLCCWGRTRESAISNMARALREYKILGIKTTIPF
CCCCEEECCCEECCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEECCHH
HQRVLKNAAFLEGKYDTTFIDTRFDKEDLKRRQNTDPTVAVIAAAVRHYEREKEAASRAT
HHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TLPVVGESLWKYYGKLQMTANNY
CCHHHHHHHHHHHCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]