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The map label for this gene is ypnP [H]

Identifier: 29346797

GI number: 29346797

Start: 1714158

End: 1715522

Strand: Reverse

Name: ypnP [H]

Synonym: BT_1387

Alternate gene names: 29346797

Gene position: 1715522-1714158 (Counterclockwise)

Preceding gene: 29346798

Following gene: 29346796

Centisome position: 27.4

GC content: 46.37

Gene sequence:

>1365_bases
ATGAAGGAGTTAAATTTGACACAAGGGAGTGTTCCGAAAGTATTACTGCAATATGCGGTTCCTTTTCTGATTGCCAATGT
GCTTCAGGCACTTTATGGCGGGGCCGACCTTTTTGTGGTGGGACAATACGATGATTCTGCAAGTGTGGCGGCTGTAGCCA
TCGGCAGTCAGGTGATGCAGACAATTACGGGGATTATTCTTGGCATTACGACAGGAACAACCGTTTTGATTGCCATCGCT
ACCGGAGCAAAGGATGACAAGAAAGTAGCTTTCACCATCGGTTCGTCTGTATGGTTGTTTTCAATAATCGGGGTGCTGCT
TACTTTGGTCATGGTGGTTTTTCATGGTCGGATAGCAGAGTTAATGCATACGCCGATAGAGGCGATGGCGGATACGAAAA
GTTACATCCTTGTATGTTCGGCCGGGATATTGTTTATAGTAGGATATAACGTCGTATGCGGTATTTTGCGCGGGTTGGGA
GACTCCAAGACGCCGCTTTATTTTGTAGCGCTGGCGTGTGTGATTAATATTGTACTCGATTTTATACTGGTAGGATATTT
CCATTTGGGAGCCACAGGAGCGGCAGTTGCCACCATAACGGCGCAGGGAGTCAGCTTCATGATCTCTCTTTGGTTCTTAT
ATCGGCACGGATTTCATTTTGAGTTTACCCGGAAAGATATCCGGCTGAACCGGAACCTGGCCAAGAAAGTCATGACATTG
GGAGCGCCTATTGCGTTGCAGGATGCGCTGATCAATATCTCGTTTCTGATCATCACCGTTATAGTCAATCAGATGGGAGT
GATCGCATCGGCTTCTTTGGGTGTCGTAGAGAAAATTATAGTGTTTGCCATGCTGCCTCCGATGGCAATCTCATCGGCAG
TAGCGACGATGACGGCACAGAACTACGGAGCCGGACTTATACAACGGATGAACCGCTGTCTGGCTTCGGGGATAGGAATT
GCATTTGTTTTCGGTGTATCGGTTTGTGTGTATTCACAATTCCTGCCGGAAACGCTTACCGCGTTCTTTACCAAAGATGC
GGCGGTGGTATCAATGGCGGCGGAGTATCTGCGGGGATATAGTATCGACTGTATCGTTGTAAGTTTTGTGTTCTGTATAA
ACTCTTACTTCAGCGGACAGGGAAATTCATTGTTCCCGATGATTCACAGTCTGATAGCGACTTTCCTGTTCCGGATTCCG
TTGTCGTACTGGTTTAGTCAGATAGACAGTTCTTCCTTGTTTATCATGGGCTTTGCACCACCTCTTTCAACAGTGGTTTC
ATTGTTGATCTGTATCTGGTATTTAAGATATACCCGGAAGAAAGTTTATTTGAAAGGCACCATGATGCCTGCTATGTCGA
ATTAG

Upstream 100 bases:

>100_bases
TTATAGTGCTGGATAAGATGAATGGTGTGAATCATTCAGCTTGTCCGGCACTTTTTTATTTTGTAACAAGTAAGATAAGA
GGAGTAAGTATTGAAAAACT

Downstream 100 bases:

>100_bases
GTGTTTTAAGTGGATATATTAACTAAAATCAATTTGTATGGAAGCTTATTTGAAGAAACTCTGTTTTGAGTATCAGGTTG
AAGAAAAGGAAGTGAAAGAG

Product: putative Na+-driven multidrug efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKELNLTQGSVPKVLLQYAVPFLIANVLQALYGGADLFVVGQYDDSASVAAVAIGSQVMQTITGIILGITTGTTVLIAIA
TGAKDDKKVAFTIGSSVWLFSIIGVLLTLVMVVFHGRIAELMHTPIEAMADTKSYILVCSAGILFIVGYNVVCGILRGLG
DSKTPLYFVALACVINIVLDFILVGYFHLGATGAAVATITAQGVSFMISLWFLYRHGFHFEFTRKDIRLNRNLAKKVMTL
GAPIALQDALINISFLIITVIVNQMGVIASASLGVVEKIIVFAMLPPMAISSAVATMTAQNYGAGLIQRMNRCLASGIGI
AFVFGVSVCVYSQFLPETLTAFFTKDAAVVSMAAEYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRIP
LSYWFSQIDSSSLFIMGFAPPLSTVVSLLICIWYLRYTRKKVYLKGTMMPAMSN

Sequences:

>Translated_454_residues
MKELNLTQGSVPKVLLQYAVPFLIANVLQALYGGADLFVVGQYDDSASVAAVAIGSQVMQTITGIILGITTGTTVLIAIA
TGAKDDKKVAFTIGSSVWLFSIIGVLLTLVMVVFHGRIAELMHTPIEAMADTKSYILVCSAGILFIVGYNVVCGILRGLG
DSKTPLYFVALACVINIVLDFILVGYFHLGATGAAVATITAQGVSFMISLWFLYRHGFHFEFTRKDIRLNRNLAKKVMTL
GAPIALQDALINISFLIITVIVNQMGVIASASLGVVEKIIVFAMLPPMAISSAVATMTAQNYGAGLIQRMNRCLASGIGI
AFVFGVSVCVYSQFLPETLTAFFTKDAAVVSMAAEYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRIP
LSYWFSQIDSSSLFIMGFAPPLSTVVSLLICIWYLRYTRKKVYLKGTMMPAMSN
>Mature_454_residues
MKELNLTQGSVPKVLLQYAVPFLIANVLQALYGGADLFVVGQYDDSASVAAVAIGSQVMQTITGIILGITTGTTVLIAIA
TGAKDDKKVAFTIGSSVWLFSIIGVLLTLVMVVFHGRIAELMHTPIEAMADTKSYILVCSAGILFIVGYNVVCGILRGLG
DSKTPLYFVALACVINIVLDFILVGYFHLGATGAAVATITAQGVSFMISLWFLYRHGFHFEFTRKDIRLNRNLAKKVMTL
GAPIALQDALINISFLIITVIVNQMGVIASASLGVVEKIIVFAMLPPMAISSAVATMTAQNYGAGLIQRMNRCLASGIGI
AFVFGVSVCVYSQFLPETLTAFFTKDAAVVSMAAEYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRIP
LSYWFSQIDSSSLFIMGFAPPLSTVVSLLICIWYLRYTRKKVYLKGTMMPAMSN

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=357, Percent_Identity=23.249299719888, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI226510954, Length=398, Percent_Identity=22.3618090452261, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49083; Mature: 49083

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELNLTQGSVPKVLLQYAVPFLIANVLQALYGGADLFVVGQYDDSASVAAVAIGSQVMQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
TITGIILGITTGTTVLIAIATGAKDDKKVAFTIGSSVWLFSIIGVLLTLVMVVFHGRIAE
HHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LMHTPIEAMADTKSYILVCSAGILFIVGYNVVCGILRGLGDSKTPLYFVALACVINIVLD
HHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FILVGYFHLGATGAAVATITAQGVSFMISLWFLYRHGFHFEFTRKDIRLNRNLAKKVMTL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
GAPIALQDALINISFLIITVIVNQMGVIASASLGVVEKIIVFAMLPPMAISSAVATMTAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NYGAGLIQRMNRCLASGIGIAFVFGVSVCVYSQFLPETLTAFFTKDAAVVSMAAEYLRGY
HCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
SIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRIPLSYWFSQIDSSSLFIMGFAP
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PLSTVVSLLICIWYLRYTRKKVYLKGTMMPAMSN
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCC
>Mature Secondary Structure
MKELNLTQGSVPKVLLQYAVPFLIANVLQALYGGADLFVVGQYDDSASVAAVAIGSQVMQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
TITGIILGITTGTTVLIAIATGAKDDKKVAFTIGSSVWLFSIIGVLLTLVMVVFHGRIAE
HHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LMHTPIEAMADTKSYILVCSAGILFIVGYNVVCGILRGLGDSKTPLYFVALACVINIVLD
HHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FILVGYFHLGATGAAVATITAQGVSFMISLWFLYRHGFHFEFTRKDIRLNRNLAKKVMTL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
GAPIALQDALINISFLIITVIVNQMGVIASASLGVVEKIIVFAMLPPMAISSAVATMTAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NYGAGLIQRMNRCLASGIGIAFVFGVSVCVYSQFLPETLTAFFTKDAAVVSMAAEYLRGY
HCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
SIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRIPLSYWFSQIDSSSLFIMGFAP
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PLSTVVSLLICIWYLRYTRKKVYLKGTMMPAMSN
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]