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The map label for this gene is lon [H]

Identifier: 29346247

GI number: 29346247

Start: 1032027

End: 1033907

Strand: Reverse

Name: lon [H]

Synonym: BT_0837

Alternate gene names: 29346247

Gene position: 1033907-1032027 (Counterclockwise)

Preceding gene: 29346250

Following gene: 29346246

Centisome position: 16.52

GC content: 43.7

Gene sequence:

>1881_bases
ATGAAAGAAAGATACTTATTGGAAGAAGAAGTTGGTGAGAACGGCTTCTCACTGATTACCGACTATGATGGCAATGACGA
ACATGTGTTTGATGTGAATATAAAATCCGGTGATATTCTTCCGGTTCTCCCCCTTCGTAATATGGTGTTGTTTCCCGGAG
TATTTTTACCTATTACAGTAGGCAGAAAGGCTTCATTAAAGCTGGTTCGCGAAGCTGAAAAGAAACACAAAGATATTGCA
GTGATTTGCCAGAGATCGGCACACACGGAAGACCCCAAACTGGAAGATTTGCACAATGTCGGCACTGTCGGACGAATTGT
ACGGGTACTGGAAATGCCTGACCAGACAACAACAGTCATCCTTCAGGGAATGAAACGTCTGCGTCTGAAAGATATTGTAG
ATACACACCCTTATCTGAAGGGCGAGGTCGAACTTTTGGAAGAAGATGTCCCAAACAAAGACGATAAAGAGTTTCAAGCC
CTGGTTGAAACATGCAAGGACTTGACGATGCGTTATATCAAATCATCAGAAATGCATCAGGACTCGTCATTTGCTATAAA
AAACATCAGTAATCCGATGTTCCTCATTAATTTCATTTGTGCCAACCTGCCATTCAAGAAAGATGAGAAGATGGATTTAT
TAAGTATCAACTCATTAAGAGAGCGTACTTATCATCTATTGGAAATCTTGAATCGCGAAGTACAGCTGGCAGAAATCAAG
GCATCCATCCAAATGCGTGCCCGTGAGGATATCGATCAGCAACAGCGTGAATACTTCCTCCAACAACAGATCAAAACGAT
CCAGGATGAACTGGGTGGCAGCGGTCAGGAGCAGGAAATTGAAGAAATGCGCCTGAAAGCAGTTAAAATGCACTGGAATG
CAGAAGTAAGAGATACTTTCCTGAAGGAACTGGCGAAACTGGAACGTACACATCCGCAATCACCGGACTTCAGCGTACAA
CTCAACTATCTGCAAACAATGCTCAACCTGCCTTGGGGTGTTTATACAACAGACAATCTGAATTTGAAAAATGCAGAAAA
GACGTTGAATAAAGACCACTACGGACTGGAAAAAGTAAAAGAACGTATTCTGGAACACCTTGCCGTATTAAAACTGAAAG
GCGATATGAAATCACCTATTATCTGTTTGTACGGCCCTCCGGGAGTTGGTAAAACATCCCTCGGAAAATCCATCGCATCG
GCACTGAAACGAAAATATGTCCGTATGTCTTTGGGTGGTGTGCACGATGAAGCAGAAATTCGCGGTCACCGCAAAACTTA
TATTGGCGCTATGCCCGGACGAATCATCAAGAGTCTGATTAAGGCAGGAGCCTCTAATCCTGTATTTATACTGGATGAGA
TCGACAAAGTCAGTGCCGACCGTCAAGGCGATCCGTCATCAGCTTTGCTGGAAGTACTTGATCCGGAACAGAATACCTCT
TTCCATGATAACTTCCTGGATGTAGATTATGACCTTTCCAAAGTACTGTTCATTGCAACCGCCAATAATCTGAATACGAT
CCCCGGCCCGTTGCTCGACCGTATGGAGCTGATTGAAGTCAGCGGATACATCACGGAAGAAAAAGTTGAAATTGCCCGTA
AGCACCTGTTGCCGAAAGAACTGGAAGCAAACGGACTTAAAAAGACGGATATCAAGATTCCGAAAGATACTTTGGAAGCG
ATTATCGAATCATATACCCGTGAAAGCGGCGTCCGTGAACTGGAAAAGAAAATCGGCAAGATTCTCCGCAAATCTGCCCG
TCAATATGCAACAGACGGTTATTTCGCCAAATCAGAAATTAAACCGACTGATTTGTATGAATTCCTGGGAGCACCGGAGT
ATACTCGTGACAATATCAGGGAAATGACTATGCAGGCGTAG

Upstream 100 bases:

>100_bases
TTTTTATTCCACACTGTGCTTTATTATTAAAGAGAATCAATTAACTTTGCAAACGATTTATGCATATTATGTATGACATA
AACTAAATTAAAACGAAAAG

Downstream 100 bases:

>100_bases
TCACCGGACTGGCATGGACTGCCGTCGGCGGTGAAATACTCTTTGTAGAAACGAGTCTGAGCCGTGGTAAAGGTGCGCGT
CTTACACTAACAGGTAATTT

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MKERYLLEEEVGENGFSLITDYDGNDEHVFDVNIKSGDILPVLPLRNMVLFPGVFLPITVGRKASLKLVREAEKKHKDIA
VICQRSAHTEDPKLEDLHNVGTVGRIVRVLEMPDQTTTVILQGMKRLRLKDIVDTHPYLKGEVELLEEDVPNKDDKEFQA
LVETCKDLTMRYIKSSEMHQDSSFAIKNISNPMFLINFICANLPFKKDEKMDLLSINSLRERTYHLLEILNREVQLAEIK
ASIQMRAREDIDQQQREYFLQQQIKTIQDELGGSGQEQEIEEMRLKAVKMHWNAEVRDTFLKELAKLERTHPQSPDFSVQ
LNYLQTMLNLPWGVYTTDNLNLKNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSIAS
ALKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAGASNPVFILDEIDKVSADRQGDPSSALLEVLDPEQNTS
FHDNFLDVDYDLSKVLFIATANNLNTIPGPLLDRMELIEVSGYITEEKVEIARKHLLPKELEANGLKKTDIKIPKDTLEA
IIESYTRESGVRELEKKIGKILRKSARQYATDGYFAKSEIKPTDLYEFLGAPEYTRDNIREMTMQA

Sequences:

>Translated_626_residues
MKERYLLEEEVGENGFSLITDYDGNDEHVFDVNIKSGDILPVLPLRNMVLFPGVFLPITVGRKASLKLVREAEKKHKDIA
VICQRSAHTEDPKLEDLHNVGTVGRIVRVLEMPDQTTTVILQGMKRLRLKDIVDTHPYLKGEVELLEEDVPNKDDKEFQA
LVETCKDLTMRYIKSSEMHQDSSFAIKNISNPMFLINFICANLPFKKDEKMDLLSINSLRERTYHLLEILNREVQLAEIK
ASIQMRAREDIDQQQREYFLQQQIKTIQDELGGSGQEQEIEEMRLKAVKMHWNAEVRDTFLKELAKLERTHPQSPDFSVQ
LNYLQTMLNLPWGVYTTDNLNLKNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSIAS
ALKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAGASNPVFILDEIDKVSADRQGDPSSALLEVLDPEQNTS
FHDNFLDVDYDLSKVLFIATANNLNTIPGPLLDRMELIEVSGYITEEKVEIARKHLLPKELEANGLKKTDIKIPKDTLEA
IIESYTRESGVRELEKKIGKILRKSARQYATDGYFAKSEIKPTDLYEFLGAPEYTRDNIREMTMQA
>Mature_626_residues
MKERYLLEEEVGENGFSLITDYDGNDEHVFDVNIKSGDILPVLPLRNMVLFPGVFLPITVGRKASLKLVREAEKKHKDIA
VICQRSAHTEDPKLEDLHNVGTVGRIVRVLEMPDQTTTVILQGMKRLRLKDIVDTHPYLKGEVELLEEDVPNKDDKEFQA
LVETCKDLTMRYIKSSEMHQDSSFAIKNISNPMFLINFICANLPFKKDEKMDLLSINSLRERTYHLLEILNREVQLAEIK
ASIQMRAREDIDQQQREYFLQQQIKTIQDELGGSGQEQEIEEMRLKAVKMHWNAEVRDTFLKELAKLERTHPQSPDFSVQ
LNYLQTMLNLPWGVYTTDNLNLKNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSIAS
ALKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAGASNPVFILDEIDKVSADRQGDPSSALLEVLDPEQNTS
FHDNFLDVDYDLSKVLFIATANNLNTIPGPLLDRMELIEVSGYITEEKVEIARKHLLPKELEANGLKKTDIKIPKDTLEA
IIESYTRESGVRELEKKIGKILRKSARQYATDGYFAKSEIKPTDLYEFLGAPEYTRDNIREMTMQA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=647, Percent_Identity=36.4760432766615, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI31377667, Length=593, Percent_Identity=37.0994940978078, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1786643, Length=579, Percent_Identity=43.1778929188256, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17505831, Length=478, Percent_Identity=40.1673640167364, Blast_Score=339, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17556486, Length=314, Percent_Identity=44.2675159235669, Blast_Score=308, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6319449, Length=407, Percent_Identity=45.7002457002457, Blast_Score=355, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24666867, Length=505, Percent_Identity=41.980198019802, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221513036, Length=505, Percent_Identity=41.980198019802, Blast_Score=361, Evalue=1e-99,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 71448; Mature: 71448

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERYLLEEEVGENGFSLITDYDGNDEHVFDVNIKSGDILPVLPLRNMVLFPGVFLPITV
CCCCCCCHHHHCCCCCEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHCCCEEEEEEC
GRKASLKLVREAEKKHKDIAVICQRSAHTEDPKLEDLHNVGTVGRIVRVLEMPDQTTTVI
CCHHHHHHHHHHHHHCCCEEEHEECCCCCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHH
LQGMKRLRLKDIVDTHPYLKGEVELLEEDVPNKDDKEFQALVETCKDLTMRYIKSSEMHQ
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DSSFAIKNISNPMFLINFICANLPFKKDEKMDLLSINSLRERTYHLLEILNREVQLAEIK
CCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASIQMRAREDIDQQQREYFLQQQIKTIQDELGGSGQEQEIEEMRLKAVKMHWNAEVRDTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
LKELAKLERTHPQSPDFSVQLNYLQTMLNLPWGVYTTDNLNLKNAEKTLNKDHYGLEKVK
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
ERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSIASALKRKYVRMSLGGVHDEAEI
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RGHRKTYIGAMPGRIIKSLIKAGASNPVFILDEIDKVSADRQGDPSSALLEVLDPEQNTS
CCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCC
FHDNFLDVDYDLSKVLFIATANNLNTIPGPLLDRMELIEVSGYITEEKVEIARKHLLPKE
CCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
LEANGLKKTDIKIPKDTLEAIIESYTRESGVRELEKKIGKILRKSARQYATDGYFAKSEI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
KPTDLYEFLGAPEYTRDNIREMTMQA
CHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKERYLLEEEVGENGFSLITDYDGNDEHVFDVNIKSGDILPVLPLRNMVLFPGVFLPITV
CCCCCCCHHHHCCCCCEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHCCCEEEEEEC
GRKASLKLVREAEKKHKDIAVICQRSAHTEDPKLEDLHNVGTVGRIVRVLEMPDQTTTVI
CCHHHHHHHHHHHHHCCCEEEHEECCCCCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHH
LQGMKRLRLKDIVDTHPYLKGEVELLEEDVPNKDDKEFQALVETCKDLTMRYIKSSEMHQ
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DSSFAIKNISNPMFLINFICANLPFKKDEKMDLLSINSLRERTYHLLEILNREVQLAEIK
CCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASIQMRAREDIDQQQREYFLQQQIKTIQDELGGSGQEQEIEEMRLKAVKMHWNAEVRDTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
LKELAKLERTHPQSPDFSVQLNYLQTMLNLPWGVYTTDNLNLKNAEKTLNKDHYGLEKVK
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
ERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSIASALKRKYVRMSLGGVHDEAEI
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RGHRKTYIGAMPGRIIKSLIKAGASNPVFILDEIDKVSADRQGDPSSALLEVLDPEQNTS
CCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCC
FHDNFLDVDYDLSKVLFIATANNLNTIPGPLLDRMELIEVSGYITEEKVEIARKHLLPKE
CCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
LEANGLKKTDIKIPKDTLEAIIESYTRESGVRELEKKIGKILRKSARQYATDGYFAKSEI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
KPTDLYEFLGAPEYTRDNIREMTMQA
CHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA