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The map label for this gene is lon [H]

Identifier: 29346246

GI number: 29346246

Start: 1031443

End: 1031916

Strand: Reverse

Name: lon [H]

Synonym: BT_0836

Alternate gene names: 29346246

Gene position: 1031916-1031443 (Counterclockwise)

Preceding gene: 29346247

Following gene: 29346245

Centisome position: 16.48

GC content: 42.41

Gene sequence:

>474_bases
ATGAAAGAATCAGCTATGCTGGCACTCGAATACATCAAAGCACATGCTTCCATCCTCGATCTGAATGAAGACATCTTTGA
CAACTGGAATATACATATCCATGTCCCCGAAGGTGCTATTCCGAAAGATGGACCGTCGGCAGGTATTACTATGGCTACTT
CTTTAGCTTCTGCCCTCACCCAAAGAAAGGTAAAAGCAAACCTTGCCATGACGGGAGAAATCACTCTCCGTGGCAAAGTG
CTTCCTGTCGGTGGTATCAAAGAGAAGATTCTTGCCGCCAAACGTGCCGGAATCAAAGAAATCATCATGAGTGCCGAAAA
TAAAAAGAACATAGATGAAATTCAGGACATATATTTAAAAGGACTGCAATTCCACTATGTAAACGACATTAAAGAAGTAT
TCGCAATCGCCTTGACAAACGAGAAAGTTGCGGATGCCATTGATTTATCTGTAAAGAAACCCAGCCAGGAATGA

Upstream 100 bases:

>100_bases
GGCATGGACTGCCGTCGGCGGTGAAATACTCTTTGTAGAAACGAGTCTGAGCCGTGGTAAAGGTGCGCGTCTTACACTAA
CAGGTAATTTGGGAGATGTA

Downstream 100 bases:

>100_bases
CATTTGAGTTACAATATACAGACACTAAAAGTAATGCCCGTGCAGGTCTGATAACAACAGACCACGGGCAGATACAAACA
CCTATCTTCATGCCTGTGGG

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKESAMLALEYIKAHASILDLNEDIFDNWNIHIHVPEGAIPKDGPSAGITMATSLASALTQRKVKANLAMTGEITLRGKV
LPVGGIKEKILAAKRAGIKEIIMSAENKKNIDEIQDIYLKGLQFHYVNDIKEVFAIALTNEKVADAIDLSVKKPSQE

Sequences:

>Translated_157_residues
MKESAMLALEYIKAHASILDLNEDIFDNWNIHIHVPEGAIPKDGPSAGITMATSLASALTQRKVKANLAMTGEITLRGKV
LPVGGIKEKILAAKRAGIKEIIMSAENKKNIDEIQDIYLKGLQFHYVNDIKEVFAIALTNEKVADAIDLSVKKPSQE
>Mature_157_residues
MKESAMLALEYIKAHASILDLNEDIFDNWNIHIHVPEGAIPKDGPSAGITMATSLASALTQRKVKANLAMTGEITLRGKV
LPVGGIKEKILAAKRAGIKEIIMSAENKKNIDEIQDIYLKGLQFHYVNDIKEVFAIALTNEKVADAIDLSVKKPSQE

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=142, Percent_Identity=49.2957746478873, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI31377667, Length=143, Percent_Identity=46.8531468531469, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786643, Length=141, Percent_Identity=53.9007092198582, Blast_Score=160, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17505831, Length=134, Percent_Identity=45.5223880597015, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17556486, Length=109, Percent_Identity=41.2844036697248, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319449, Length=133, Percent_Identity=45.1127819548872, Blast_Score=115, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24666867, Length=140, Percent_Identity=47.1428571428571, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI221513036, Length=140, Percent_Identity=47.1428571428571, Blast_Score=140, Evalue=4e-34,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 17178; Mature: 17178

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESAMLALEYIKAHASILDLNEDIFDNWNIHIHVPEGAIPKDGPSAGITMATSLASALT
CCCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
QRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIIMSAENKKNIDEIQDIYLK
HHHHHHCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHH
GLQFHYVNDIKEVFAIALTNEKVADAIDLSVKKPSQE
CCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKESAMLALEYIKAHASILDLNEDIFDNWNIHIHVPEGAIPKDGPSAGITMATSLASALT
CCCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
QRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIIMSAENKKNIDEIQDIYLK
HHHHHHCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHH
GLQFHYVNDIKEVFAIALTNEKVADAIDLSVKKPSQE
CCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA