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The map label for this gene is mepA [H]

Identifier: 29346106

GI number: 29346106

Start: 866986

End: 868356

Strand: Reverse

Name: mepA [H]

Synonym: BT_0696

Alternate gene names: 29346106

Gene position: 868356-866986 (Counterclockwise)

Preceding gene: 29346110

Following gene: 29346102

Centisome position: 13.87

GC content: 45.22

Gene sequence:

>1371_bases
ATGAGCAAAAACGATCCGCACATATTAGGAAAAGAAAGCATCGGTAAACTACTGTTGCAATACTCCATTCCCGCTATCAT
CGGGATGACAATCACGTCTATCTATAATATCATCGACAGCATCTTCATCGGTCACGGTGTGGGTGCGATGGCTATTGCCG
GACTGGCGGTGAGCTTTCCTCTGATGAATCTGGTCGTTGCTTTCTGTACACTCGTTTCGGCGGGTGGTTCTACCATCGCT
TCTATTCGCCTGGGACAGAAAGATATGAAAGGGGCTACGGAGATTCTGTCACATACGCTGATGCTCTGTATCACAAATTC
TTTCTTTTTCGGTATCCTGTCTTTTATCTTTCTTGATGATATACTGACTTTCTTTGGTGCCAGTCCCGACACACTGCCTT
ATGCACGGAGTTTTATGCAGGTGATTTTATTGGGAACTCCCATCACATACACGATGATCGGTCTGAATAATGTGATGCGT
GCCACCGGATATCCGAAGAAAGCGATGCTTACTTCTATGGTAACGGTAGTAGCAAATATCATCCTCGCTCCTATCTTTAT
CTTTCACTTTGAATGGGGAATGCGGGGAGCGGCTACAGCAACGGTTATCTCACAGCTGATCGGAATGGTATGGGTGGTGA
GCCACTTCTGCAAGAAAGACAGTACGGTGCATTTTGAGGGAAAGGTCTGGAAAATGAAAGGAAGGATTGTAGAGAGTATT
TTCGCTATCGGCATGTCTCCTTTCCTGATGAATGTCTGTGCTTGTGCCATCGTTATCGTGATTAATAATAGTTTGCAGGA
ACATGGAGGCGACATGGCTATCGGTGCTTACGGAATCATCAACCGGTTGCTGACGCTTTATGTCATGATCGTATTGGGAC
TGACGATGGGCATGCAGCCGATTGTAGGCTACAACTTCGGAGCACAGAAGATAGACCGGGTGAAACAGACGCTAAAGCTG
GGAATTATTTCCGGTGTAGTGATTACAAGCAGTGGCTTTCTGATTTGCGAGTTTTTCCCTCATGCAGTATCGGCAGTCTT
CACGGATAGTGATGAGTTAATCGGACTTGCGGTGGACGGTCTTCGGTTGACTGTACTTATGTTCCCGTTTGTAGGAGCAC
AGATTGTAATCGGTAACTTCTTCCAAAGTATAGGCAAAGTAAAAATAAGTATTTTCCTTTCGTTGACGCGGCAGTTGCTT
TATTTGCTGCCTTGCCTGTTGTTATTCCCGCATTGGTGGGGACTGAAGGGAATATGGATCAGTCTGCCGGTATCGGACTC
TTTAGCATTTATTACGGCAGTTATCAGTCTGATGATTTATATAAAGAAAGTATCGAAAGAACATCCGATAGCGGATAAAG
TGGCGGAATAA

Upstream 100 bases:

>100_bases
CAAAGTTCCGAATAATCATCGAATCAGGCAAATAATTCGTACCTTTGCCCCACTTAAAAAAACGTAACATTCGTTTTCAT
CCAACAATCCATACGAGCGC

Downstream 100 bases:

>100_bases
AGCAAAAAGGACGCTATGCTAAAAGATATATCAGTATGAAAAATATTTAGGCACGAATACACGGATTAAGATTACTTCTG
CAATGAATGCATCTCATAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSKNDPHILGKESIGKLLLQYSIPAIIGMTITSIYNIIDSIFIGHGVGAMAIAGLAVSFPLMNLVVAFCTLVSAGGSTIA
SIRLGQKDMKGATEILSHTLMLCITNSFFFGILSFIFLDDILTFFGASPDTLPYARSFMQVILLGTPITYTMIGLNNVMR
ATGYPKKAMLTSMVTVVANIILAPIFIFHFEWGMRGAATATVISQLIGMVWVVSHFCKKDSTVHFEGKVWKMKGRIVESI
FAIGMSPFLMNVCACAIVIVINNSLQEHGGDMAIGAYGIINRLLTLYVMIVLGLTMGMQPIVGYNFGAQKIDRVKQTLKL
GIISGVVITSSGFLICEFFPHAVSAVFTDSDELIGLAVDGLRLTVLMFPFVGAQIVIGNFFQSIGKVKISIFLSLTRQLL
YLLPCLLLFPHWWGLKGIWISLPVSDSLAFITAVISLMIYIKKVSKEHPIADKVAE

Sequences:

>Translated_456_residues
MSKNDPHILGKESIGKLLLQYSIPAIIGMTITSIYNIIDSIFIGHGVGAMAIAGLAVSFPLMNLVVAFCTLVSAGGSTIA
SIRLGQKDMKGATEILSHTLMLCITNSFFFGILSFIFLDDILTFFGASPDTLPYARSFMQVILLGTPITYTMIGLNNVMR
ATGYPKKAMLTSMVTVVANIILAPIFIFHFEWGMRGAATATVISQLIGMVWVVSHFCKKDSTVHFEGKVWKMKGRIVESI
FAIGMSPFLMNVCACAIVIVINNSLQEHGGDMAIGAYGIINRLLTLYVMIVLGLTMGMQPIVGYNFGAQKIDRVKQTLKL
GIISGVVITSSGFLICEFFPHAVSAVFTDSDELIGLAVDGLRLTVLMFPFVGAQIVIGNFFQSIGKVKISIFLSLTRQLL
YLLPCLLLFPHWWGLKGIWISLPVSDSLAFITAVISLMIYIKKVSKEHPIADKVAE
>Mature_455_residues
SKNDPHILGKESIGKLLLQYSIPAIIGMTITSIYNIIDSIFIGHGVGAMAIAGLAVSFPLMNLVVAFCTLVSAGGSTIAS
IRLGQKDMKGATEILSHTLMLCITNSFFFGILSFIFLDDILTFFGASPDTLPYARSFMQVILLGTPITYTMIGLNNVMRA
TGYPKKAMLTSMVTVVANIILAPIFIFHFEWGMRGAATATVISQLIGMVWVVSHFCKKDSTVHFEGKVWKMKGRIVESIF
AIGMSPFLMNVCACAIVIVINNSLQEHGGDMAIGAYGIINRLLTLYVMIVLGLTMGMQPIVGYNFGAQKIDRVKQTLKLG
IISGVVITSSGFLICEFFPHAVSAVFTDSDELIGLAVDGLRLTVLMFPFVGAQIVIGNFFQSIGKVKISIFLSLTRQLLY
LLPCLLLFPHWWGLKGIWISLPVSDSLAFITAVISLMIYIKKVSKEHPIADKVAE

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49659; Mature: 49528

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNDPHILGKESIGKLLLQYSIPAIIGMTITSIYNIIDSIFIGHGVGAMAIAGLAVSFP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LMNLVVAFCTLVSAGGSTIASIRLGQKDMKGATEILSHTLMLCITNSFFFGILSFIFLDD
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILTFFGASPDTLPYARSFMQVILLGTPITYTMIGLNNVMRATGYPKKAMLTSMVTVVANI
HHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ILAPIFIFHFEWGMRGAATATVISQLIGMVWVVSHFCKKDSTVHFEGKVWKMKGRIVESI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEHHHHHHHHH
FAIGMSPFLMNVCACAIVIVINNSLQEHGGDMAIGAYGIINRLLTLYVMIVLGLTMGMQP
HHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
IVGYNFGAQKIDRVKQTLKLGIISGVVITSSGFLICEFFPHAVSAVFTDSDELIGLAVDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEEEEECH
LRLTVLMFPFVGAQIVIGNFFQSIGKVKISIFLSLTRQLLYLLPCLLLFPHWWGLKGIWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
SLPVSDSLAFITAVISLMIYIKKVSKEHPIADKVAE
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure 
SKNDPHILGKESIGKLLLQYSIPAIIGMTITSIYNIIDSIFIGHGVGAMAIAGLAVSFP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LMNLVVAFCTLVSAGGSTIASIRLGQKDMKGATEILSHTLMLCITNSFFFGILSFIFLDD
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILTFFGASPDTLPYARSFMQVILLGTPITYTMIGLNNVMRATGYPKKAMLTSMVTVVANI
HHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ILAPIFIFHFEWGMRGAATATVISQLIGMVWVVSHFCKKDSTVHFEGKVWKMKGRIVESI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEHHHHHHHHH
FAIGMSPFLMNVCACAIVIVINNSLQEHGGDMAIGAYGIINRLLTLYVMIVLGLTMGMQP
HHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
IVGYNFGAQKIDRVKQTLKLGIISGVVITSSGFLICEFFPHAVSAVFTDSDELIGLAVDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEEEEECH
LRLTVLMFPFVGAQIVIGNFFQSIGKVKISIFLSLTRQLLYLLPCLLLFPHWWGLKGIWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
SLPVSDSLAFITAVISLMIYIKKVSKEHPIADKVAE
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA