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The map label for this gene is ygcA [C]

Identifier: 29346053

GI number: 29346053

Start: 791691

End: 793055

Strand: Reverse

Name: ygcA [C]

Synonym: BT_0643

Alternate gene names: 29346053

Gene position: 793055-791691 (Counterclockwise)

Preceding gene: 29346057

Following gene: 29346052

Centisome position: 12.67

GC content: 45.05

Gene sequence:

>1365_bases
GTGGCTGCCGAAGGAAAAGCCATCGCAAAAGTAAACGACCTGGTGATTTTTGTTCCTTATGTAGTGCCAGGTGATGTTGT
AGACCTGCAGATCAAGCGCAAAAAGAACAAATACGCCGAAGCCGAAGCTGTGAAATTCCACGAGCTGTCGCCCGTACGTG
CCGTTCCTTTCTGCCAACACTACGGCGTATGCGGCGGTTGTAAATGGCAGGTACTCCCCTATTCGGAACAAATCAGGTAT
AAGCAGAAACAAGTAGAAGACAATCTGAGACGCATCGGAAAGATCGAACTTCCGGAAATTTCACCGATTCTGGGTTCTGC
CAAAACAGAGTTCTACCGGAATAAACTGGAGTTCACTTTTTCGAACAAACGCTGGCTCACGAACGATGAAGTTCGGCAGG
ATGTGAAGTATGATCAGATGAATGCTGTAGGTTTTCATATTCCCGGAGCTTTCGACAAAGTGCTGGCTATTGAAAAATGC
TGGTTACAGGACGACATCTCCAATCGTATTCGTAATGCTGTACGCGATTATGCTTACGAGCATGATTACTCCTTCATCAA
TCTGCGTACTCAGGAAGGTATGTTACGGAATCTGATTATCCGCACTTCATCAACAGGAGAGCTGATGGTCATTGTCATCT
GCAAGATTACAGAAGACCATGAAATGGAACTATTCAAGCAACTGCTGCAGTTCATTGCCGATTCATTCCCCGAAATCACT
TCTCTCCTATACATTATTAATAATAAGTGCAACGATACGATCAATGATCTGGATGTACATGTATTCAAGGGAAAAGACCA
TATGTTTGAAGAAATGGAAGGACTGCGTTTCAAAGTCGGTCCGAAATCATTCTATCAGACCAATTCCGAACAGGCATACA
ATTTATATAAGATAGCCCGCGAATTTGCCGGGCTGACCGGAAAGGAACTGGTATACGACCTATATACCGGAACGGGAACC
ATTGCCAATTTTGTATCCCGCCAGGCTCGTCAGGTGATTGGTATCGAGTATGTACCGGAAGCTATCGAAGACGCAAAGGT
AAATGCCGAGATTAATGAGATTAAGAATGCCTTGTTCTATGCCGGAGATATGAAAGATATGCTGACTCAGGAATTTATCA
ATCAGCATGGACGTCCGGATGTGATTATCACCGACCCTCCACGTGCAGGTATGCATCAGGATGTGGTTGATGTTATTCTG
TTTGCCGAACCGAAGCGGATTGTGTATGTAAGCTGCAACCCGGCTACGCAGGCACGCGACTTACAACTGCTTGACGGCAA
ATATAAAGTGAAAGCTGTGCAACCTGTAGATATGTTCCCGCATACGCATCATGTGGAAAATGTAGTGTTGCTGGAGCTTC
GATAA

Upstream 100 bases:

>100_bases
AAAAAAATACCTACTTTTGCATCATAATTATTAGATTGGTGTAAAAGTGGCAAGAAAGAGAAAAGAACTTCCCCTGCTGG
AGAAGGTAACAATAACGGAT

Downstream 100 bases:

>100_bases
TACGTTAGTTGAATTGTTCGCAAAAGAAAAAAGAAATGGAAAAAAGACCGAGAAGAACTCCTGCAGAAAAAGCACGTGCC
CAATATACGAACTATGCAGT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAAEGKAIAKVNDLVIFVPYVVPGDVVDLQIKRKKNKYAEAEAVKFHELSPVRAVPFCQHYGVCGGCKWQVLPYSEQIRY
KQKQVEDNLRRIGKIELPEISPILGSAKTEFYRNKLEFTFSNKRWLTNDEVRQDVKYDQMNAVGFHIPGAFDKVLAIEKC
WLQDDISNRIRNAVRDYAYEHDYSFINLRTQEGMLRNLIIRTSSTGELMVIVICKITEDHEMELFKQLLQFIADSFPEIT
SLLYIINNKCNDTINDLDVHVFKGKDHMFEEMEGLRFKVGPKSFYQTNSEQAYNLYKIAREFAGLTGKELVYDLYTGTGT
IANFVSRQARQVIGIEYVPEAIEDAKVNAEINEIKNALFYAGDMKDMLTQEFINQHGRPDVIITDPPRAGMHQDVVDVIL
FAEPKRIVYVSCNPATQARDLQLLDGKYKVKAVQPVDMFPHTHHVENVVLLELR

Sequences:

>Translated_454_residues
MAAEGKAIAKVNDLVIFVPYVVPGDVVDLQIKRKKNKYAEAEAVKFHELSPVRAVPFCQHYGVCGGCKWQVLPYSEQIRY
KQKQVEDNLRRIGKIELPEISPILGSAKTEFYRNKLEFTFSNKRWLTNDEVRQDVKYDQMNAVGFHIPGAFDKVLAIEKC
WLQDDISNRIRNAVRDYAYEHDYSFINLRTQEGMLRNLIIRTSSTGELMVIVICKITEDHEMELFKQLLQFIADSFPEIT
SLLYIINNKCNDTINDLDVHVFKGKDHMFEEMEGLRFKVGPKSFYQTNSEQAYNLYKIAREFAGLTGKELVYDLYTGTGT
IANFVSRQARQVIGIEYVPEAIEDAKVNAEINEIKNALFYAGDMKDMLTQEFINQHGRPDVIITDPPRAGMHQDVVDVIL
FAEPKRIVYVSCNPATQARDLQLLDGKYKVKAVQPVDMFPHTHHVENVVLLELR
>Mature_453_residues
AAEGKAIAKVNDLVIFVPYVVPGDVVDLQIKRKKNKYAEAEAVKFHELSPVRAVPFCQHYGVCGGCKWQVLPYSEQIRYK
QKQVEDNLRRIGKIELPEISPILGSAKTEFYRNKLEFTFSNKRWLTNDEVRQDVKYDQMNAVGFHIPGAFDKVLAIEKCW
LQDDISNRIRNAVRDYAYEHDYSFINLRTQEGMLRNLIIRTSSTGELMVIVICKITEDHEMELFKQLLQFIADSFPEITS
LLYIINNKCNDTINDLDVHVFKGKDHMFEEMEGLRFKVGPKSFYQTNSEQAYNLYKIAREFAGLTGKELVYDLYTGTGTI
ANFVSRQARQVIGIEYVPEAIEDAKVNAEINEIKNALFYAGDMKDMLTQEFINQHGRPDVIITDPPRAGMHQDVVDVILF
AEPKRIVYVSCNPATQARDLQLLDGKYKVKAVQPVDMFPHTHHVENVVLLELR

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=426, Percent_Identity=29.1079812206573, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI51173878, Length=426, Percent_Identity=29.1079812206573, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI269784680, Length=385, Percent_Identity=25.974025974026, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI269784676, Length=385, Percent_Identity=25.974025974026, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI20149688, Length=385, Percent_Identity=25.974025974026, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI269784678, Length=317, Percent_Identity=26.4984227129338, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789148, Length=454, Percent_Identity=25.9911894273128, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787083, Length=409, Percent_Identity=24.9388753056235, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790403, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997438, Length=166, Percent_Identity=34.3373493975904, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666579, Length=440, Percent_Identity=31.3636363636364, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y643_BACTN (Q8AA22)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_809556.1
- ProteinModelPortal:   Q8AA22
- SMR:   Q8AA22
- GeneID:   1072362
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_0643
- NMPDR:   fig|226186.1.peg.643
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- PhylomeDB:   Q8AA22
- ProtClustDB:   CLSK822292
- BioCyc:   BTHE226186:BT_0643-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 52202; Mature: 52070

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 412-412 BINDING 286-286 BINDING 315-315 BINDING 336-336 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAEGKAIAKVNDLVIFVPYVVPGDVVDLQIKRKKNKYAEAEAVKFHELSPVRAVPFCQH
CCCCCCCCEEECCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHEEECCCCCCCCCCHHH
YGVCGGCKWQVLPYSEQIRYKQKQVEDNLRRIGKIELPEISPILGSAKTEFYRNKLEFTF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCEEEEE
SNKRWLTNDEVRQDVKYDQMNAVGFHIPGAFDKVLAIEKCWLQDDISNRIRNAVRDYAYE
CCCCCCCCHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDYSFINLRTQEGMLRNLIIRTSSTGELMVIVICKITEDHEMELFKQLLQFIADSFPEIT
CCCEEEEEECHHCHHHHEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHH
SLLYIINNKCNDTINDLDVHVFKGKDHMFEEMEGLRFKVGPKSFYQTNSEQAYNLYKIAR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCCEEEECCHHHHCCCCHHHHHHHHHHH
EFAGLTGKELVYDLYTGTGTIANFVSRQARQVIGIEYVPEAIEDAKVNAEINEIKNALFY
HHCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHCHHHCCHHHHCCCCCCHHHHHHHHHEE
AGDMKDMLTQEFINQHGRPDVIITDPPRAGMHQDVVDVILFAEPKRIVYVSCNPATQARD
CCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCC
LQLLDGKYKVKAVQPVDMFPHTHHVENVVLLELR
EEEECCCEEEEEECCHHCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
AAEGKAIAKVNDLVIFVPYVVPGDVVDLQIKRKKNKYAEAEAVKFHELSPVRAVPFCQH
CCCCCCCEEECCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHEEECCCCCCCCCCHHH
YGVCGGCKWQVLPYSEQIRYKQKQVEDNLRRIGKIELPEISPILGSAKTEFYRNKLEFTF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCEEEEE
SNKRWLTNDEVRQDVKYDQMNAVGFHIPGAFDKVLAIEKCWLQDDISNRIRNAVRDYAYE
CCCCCCCCHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDYSFINLRTQEGMLRNLIIRTSSTGELMVIVICKITEDHEMELFKQLLQFIADSFPEIT
CCCEEEEEECHHCHHHHEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHH
SLLYIINNKCNDTINDLDVHVFKGKDHMFEEMEGLRFKVGPKSFYQTNSEQAYNLYKIAR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCCEEEECCHHHHCCCCHHHHHHHHHHH
EFAGLTGKELVYDLYTGTGTIANFVSRQARQVIGIEYVPEAIEDAKVNAEINEIKNALFY
HHCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHCHHHCCHHHHCCCCCCHHHHHHHHHEE
AGDMKDMLTQEFINQHGRPDVIITDPPRAGMHQDVVDVILFAEPKRIVYVSCNPATQARD
CCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCC
LQLLDGKYKVKAVQPVDMFPHTHHVENVVLLELR
EEEECCCEEEEEECCHHCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928