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The map label for this gene is uxaA [H]

Identifier: 29345896

GI number: 29345896

Start: 601684

End: 603174

Strand: Reverse

Name: uxaA [H]

Synonym: BT_0486

Alternate gene names: 29345896

Gene position: 603174-601684 (Counterclockwise)

Preceding gene: 29345897

Following gene: 29345864

Centisome position: 9.63

GC content: 46.55

Gene sequence:

>1491_bases
ATGGAAACAAAGTATTTAAGAATTAATCCTGCCGACAACGTTGCCGTTGCCATTGTTAACCTCCCGGCAGGAGAGCATCT
ATCCGTAGATGGAATAGAGATTACACTAAACGAAGACATTCCTGCTGGACATAAGTTTGCATTAAAAGATTTTGCAGAAG
GCGAGAACGTAATCAAGTACGGCTACCCTATCGGTCATGCCCGTATGGCAAAAAAACAGGGAGACTGGATGAATGAAACG
AATATCAAGACTAATCTCGCCGGACTGTTGGAGTATACCTACCATCCGACTCAGGTTACTCTGGATATCCCTCATAAAAA
CCTCACTTTTAAAGGCTACCGCCGTAAAAATGGTGATGTCGGCGTAAGAAATGAAATCTGGATTATCCCGACTGTAGGTT
GCGTTAACGGTATCATCGGACAACTGGCCGAAGGCCTGCGCCGTGAAACGGAAGGAAAAGGGGTAGATGCCATCGTGGCT
TTCCCGCACAACTACGGTTGCTCACAGCTTGGAGACGATCACGAAAACACGAAAAAGATTCTTCGCGATATGGTACTTCA
CCCGAATGCAGGCGCAGTACTGATAGTAGGCTTGGGCTGCGAAAACAACCAGCCGGACGTATTCCGTGAATTCTTAGGAG
ACTATGACCAGGACCGTGTGAAATTCATGGTAACCCAGAAAGTTGGTGACGAATACGAAGAAGGAATGGATATTCTGCGC
GATTTATATGCCAAAGCATCCAAAGATGAACGTACGGAAGTACCTTTGTCAGAACTTCGTGTCGGACTGAAATGTGGTGG
TTCCGACGGTTTCTCAGGTATCACTGCCAATCCGTTGCTGGGCATGTTCTCAGACTTCCTGATTGCACAAGGCGGTACAA
GCGTGCTGACTGAAGTTCCGGAAATGTTTGGTGCGGAAACAATTCTGATGAACCGTTGCGAGAACAAAGACCTGTTCGAA
CAGACCGTACACTTGATCAATGACTTCAAAGAATATTTCCTGTCCCATGGCGAGCCTGTGGGTGAAAATCCATCTCCGGG
AAATAAAGCCGGCGGCATCTCCACTCTGGAAGAAAAAGCACTGGGATGTACACAGAAATGTGGTAAAAGCTATGTATCCG
GCGTGATGCCTTACGGAGAACGTCTGCAAAAGAAAGGACTGAACCTGCTTTCCGCCCCGGGCAATGACCTAGTAGCTGCT
ACTACCCTTGCCGCAAGCGGATGCCATATGGTACTCTTTACCACCGGACGTGGTACTCCTTTCGGCACTTTCGTTCCGAC
GATGAAGATTTCCACCAATTCTACTTTGGCTAAAAACAAACCGGGATGGATTGATTTCAATGCCGGAGTCATCGTTGAGA
ACGAACCGATGGAAAAGACTTGCGAACGCTTTATCGAGTATGTGATTAAAGTAGCAAGCGGTGAGTTCGTTAATAACGAG
AAGAAAGGTTATCGTGAAATTGCCATCTTTAAAACAGGAGTTACATTATAA

Upstream 100 bases:

>100_bases
GACGTGACTTGCATCAACTATATGCCGATTGACTTGTTGACTGTAGAAACAATAGACTATTACCATAGCAAATAACAACA
AAATCCAACTAAACAAGTAC

Downstream 100 bases:

>100_bases
GCGTTTCACCATCAAAGGAAATATTACAGTTATGGGGAGGGTGAATTCTAAGTCCTCTCCAAACAATATCTATAAAATCT
TACCCAAGTTTACGAACATT

Product: altronate hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
METKYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKYGYPIGHARMAKKQGDWMNET
NIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDVGVRNEIWIIPTVGCVNGIIGQLAEGLRRETEGKGVDAIVA
FPHNYGCSQLGDDHENTKKILRDMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILR
DLYAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVPEMFGAETILMNRCENKDLFE
QTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKALGCTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAA
TTLAASGCHMVLFTTGRGTPFGTFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNE
KKGYREIAIFKTGVTL

Sequences:

>Translated_496_residues
METKYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKYGYPIGHARMAKKQGDWMNET
NIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDVGVRNEIWIIPTVGCVNGIIGQLAEGLRRETEGKGVDAIVA
FPHNYGCSQLGDDHENTKKILRDMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILR
DLYAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVPEMFGAETILMNRCENKDLFE
QTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKALGCTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAA
TTLAASGCHMVLFTTGRGTPFGTFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNE
KKGYREIAIFKTGVTL
>Mature_496_residues
METKYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKYGYPIGHARMAKKQGDWMNET
NIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDVGVRNEIWIIPTVGCVNGIIGQLAEGLRRETEGKGVDAIVA
FPHNYGCSQLGDDHENTKKILRDMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILR
DLYAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVPEMFGAETILMNRCENKDLFE
QTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKALGCTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAA
TTLAASGCHMVLFTTGRGTPFGTFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNE
KKGYREIAIFKTGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=494, Percent_Identity=56.2753036437247, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1789516, Length=507, Percent_Identity=34.3195266272189, Blast_Score=255, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 54356; Mature: 54356

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKY
CCCCEEEECCCCCEEEEEEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHCCCCCEEEE
GYPIGHARMAKKQGDWMNETNIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDV
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCEEEEEECCCCCCEEECCCCCCCCC
GVRNEIWIIPTVGCVNGIIGQLAEGLRRETEGKGVDAIVAFPHNYGCSQLGDDHENTKKI
CCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCHHHHHHH
LRDMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILR
HHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHHHHHH
DLYAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVP
HHHHHCCCCCCCCCCHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
EMFGAETILMNRCENKDLFEQTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKA
HHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
LGCTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAATTLAASGCHMVLFTTGRGTP
CCHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCEEEEHHHHCCCCEEEEEECCCCCC
FGTFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNE
CCCCCCEEEECCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
KKGYREIAIFKTGVTL
CCCCEEEEEEECCCCC
>Mature Secondary Structure
METKYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKY
CCCCEEEECCCCCEEEEEEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHCCCCCEEEE
GYPIGHARMAKKQGDWMNETNIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDV
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCEEEEEECCCCCCEEECCCCCCCCC
GVRNEIWIIPTVGCVNGIIGQLAEGLRRETEGKGVDAIVAFPHNYGCSQLGDDHENTKKI
CCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCHHHHHHH
LRDMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILR
HHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHHHHHH
DLYAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVP
HHHHHCCCCCCCCCCHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
EMFGAETILMNRCENKDLFEQTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKA
HHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
LGCTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAATTLAASGCHMVLFTTGRGTP
CCHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCEEEEHHHHCCCCEEEEEECCCCCC
FGTFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNE
CCCCCCEEEECCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
KKGYREIAIFKTGVTL
CCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3038546 [H]