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The map label for this gene is guaD [H]

Identifier: 29345731

GI number: 29345731

Start: 387935

End: 388405

Strand: Reverse

Name: guaD [H]

Synonym: BT_0321

Alternate gene names: 29345731

Gene position: 388405-387935 (Counterclockwise)

Preceding gene: 29345732

Following gene: 29345730

Centisome position: 6.2

GC content: 44.59

Gene sequence:

>471_bases
ATGACCAAAGAAGAACTAATGAGGAAAGCAATAGAGCTTTCGAAGGAAAATGTTGCTAATGGTGGAGGCCCGTTCGGAGC
TGTCATTGCAACAAAAGAAGGAGAAATTATAGCTACAGGAGTCAACAGAGTAACCTCTTCATGTGATCCCACTGCTCATG
CCGAAGTTAGTGCCATACGTGCCGCAGCCGCGAAACTGGGAACATTCAACCTCAGCGGATACGAAATCTATACTTCATGC
GAACCTTGCCCGATGTGTCTGGGTGCCATCTATTGGGCACGACTGGACAAAATGTATTATGGGAACAACAAGACAGATGC
CAAAAACATCGGTTTTGACGATTCCTTTATTTATGATGAGCTGGCTCTAAAACCTGCCGACAGAAAACTTCCCTCGGAAG
TATTATTGCACAACGAAGCCATTACAGCCTTTGAAGCCTGGATGTCCAAAGAAGACAAAGTAGAATATTAG

Upstream 100 bases:

>100_bases
TCTTAAAATAATTTAATCACTTTATTCTATCGTTAGTTTTCTTTATATTTGCGAAAGGTAGCAATAAAAGCAAAACTAAC
GATATTTATTTTTTATAACT

Downstream 100 bases:

>100_bases
CATCTAATCTCACTTAAACTCACTAATACTTAGTAAAATGAAAAGAAAAAACTTTTTGATTCTTCTAGCCGCAGGATGTT
TGTTCAGTTGTCAGCAACAG

Product: cytidine/deoxycytidylate deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MTKEELMRKAIELSKENVANGGGPFGAVIATKEGEIIATGVNRVTSSCDPTAHAEVSAIRAAAAKLGTFNLSGYEIYTSC
EPCPMCLGAIYWARLDKMYYGNNKTDAKNIGFDDSFIYDELALKPADRKLPSEVLLHNEAITAFEAWMSKEDKVEY

Sequences:

>Translated_156_residues
MTKEELMRKAIELSKENVANGGGPFGAVIATKEGEIIATGVNRVTSSCDPTAHAEVSAIRAAAAKLGTFNLSGYEIYTSC
EPCPMCLGAIYWARLDKMYYGNNKTDAKNIGFDDSFIYDELALKPADRKLPSEVLLHNEAITAFEAWMSKEDKVEY
>Mature_155_residues
TKEELMRKAIELSKENVANGGGPFGAVIATKEGEIIATGVNRVTSSCDPTAHAEVSAIRAAAAKLGTFNLSGYEIYTSCE
PCPMCLGAIYWARLDKMYYGNNKTDAKNIGFDDSFIYDELALKPADRKLPSEVLLHNEAITAFEAWMSKEDKVEY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=108, Percent_Identity=34.2592592592593, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554608, Length=153, Percent_Identity=45.0980392156863, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555996, Length=153, Percent_Identity=44.4444444444444, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17097; Mature: 16965

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEELMRKAIELSKENVANGGGPFGAVIATKEGEIIATGVNRVTSSCDPTAHAEVSAIR
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECHHHHHCCCCCCCHHHHHHHH
AAAAKLGTFNLSGYEIYTSCEPCPMCLGAIYWARLDKMYYGNNKTDAKNIGFDDSFIYDE
HHHHHHCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LALKPADRKLPSEVLLHNEAITAFEAWMSKEDKVEY
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TKEELMRKAIELSKENVANGGGPFGAVIATKEGEIIATGVNRVTSSCDPTAHAEVSAIR
CHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECHHHHHCCCCCCCHHHHHHHH
AAAAKLGTFNLSGYEIYTSCEPCPMCLGAIYWARLDKMYYGNNKTDAKNIGFDDSFIYDE
HHHHHHCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LALKPADRKLPSEVLLHNEAITAFEAWMSKEDKVEY
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]