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The map label for this gene is lplA [H]

Identifier: 29144845

GI number: 29144845

Start: 4766131

End: 4767147

Strand: Reverse

Name: lplA [H]

Synonym: t4615

Alternate gene names: 29144845

Gene position: 4767147-4766131 (Counterclockwise)

Preceding gene: 29144846

Following gene: 29144839

Centisome position: 99.48

GC content: 57.13

Gene sequence:

>1017_bases
ATGACAACATTACGCCTGCTTATTTCTGACTCTTACGATCCCTGGTTTAACCTGGCGGTCGAGGAGTGCATTTTCCGCCA
GATGCCCGCCACCCAGCGCGTGCTGTTCCTGTGGCGCAACGCGGACACGGTGGTCATTGGACGCGCGCAAAACCCGTGGA
AAGAGTGTAATACGCGGCGTATGGAAGAAGATAACGTCCGTCTGGCCCGCCGTAGCAGTGGCGGCGGCGCGGTATTCCAT
GACCTCGGTAATACCTGCTTTACCTTTATGGCCGGTAAACCGGAATACGATAAAACCATCTCCACCCATATTGTGCTCGC
GGCGCTGAATTCGCTGGGCGTCATGGCCGATGCTTCAGGACGCAACGATCTGGTCGTAAAAACGCCGGACGGCGATCGCA
AAGTCTCCGGTTCAGCCTATCGCGAAACCAAAGATCGCGGCTTCCATCACGGTACGCTGCTGCTGAACGCCGACCTCAGC
CGTCTGGCAAACTATCTGAATCCGGATAAAAAGAAACTTGCGGCGAAAGGAATCACCTCCGTTCGCTCCCGCGTAGCCAA
TCTTACCGAGTTATTACCGGGTATCACCCATGAACAGGTCTGCCAGGCGGTCACGGAAGCCTTTTTCGCCCATTACGGCG
AACGCATCGACGCGGAAGTGATTTCACCGGATAAAACGCCGGATCTGCCGAATTTTACCGAAACCTTTGCGCGCCAGAGC
AGTTGGGAGTGGAATTTCGGCCAGGCACCGGCGTTCAGCCATCTGCTGGACGAGCGTTTCACCTGGGGCGGCGTCGAGCT
GCATTTTGACGTAGAGAAAGGTGTGATTACTCGCGCACAGGCGTTTACCGATAGCCTGAACCCGGCACCGCTGGAAGCGC
TGGCGGGGCGGCTGCAAGGCTGCCAGTATCGGGCGGATAAACTACAGGAAACGTGCGAAGCGCTGATAGCGACGTTTCCG
GAACAGGAGAGTGAGTTGCGGGAACTGGCGAATTGGGTCGCAGGGGCCGTGCGTTAA

Upstream 100 bases:

>100_bases
GTCACCCTTCCTGTTAACGGCCAGCAAGCCTGTTCCGGAAGAGGAAGAGCGTGAGGAAAAAGAGTAAAATGACGGCTTAA
TAAAGGTAAGGAAAACCACC

Downstream 100 bases:

>100_bases
AGAATTGCCGGATGGCGGCTACGCCTTATCCGGCCTACAAATGAGTGCTTTCTGTAGGCCGGATAAGCAACGCGCCATCC
GGCATTACCGCTATTCACCA

Product: lipoate-protein ligase A

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFH
DLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLS
RLANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERIDAEVISPDKTPDLPNFTETFARQS
SWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAGRLQGCQYRADKLQETCEALIATFP
EQESELRELANWVAGAVR

Sequences:

>Translated_338_residues
MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFH
DLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLS
RLANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERIDAEVISPDKTPDLPNFTETFARQS
SWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAGRLQGCQYRADKLQETCEALIATFP
EQESELRELANWVAGAVR
>Mature_337_residues
TTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHD
LGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSR
LANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERIDAEVISPDKTPDLPNFTETFARQSS
WEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAGRLQGCQYRADKLQETCEALIATFPE
QESELRELANWVAGAVR

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=279, Percent_Identity=34.7670250896057, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI21729884, Length=279, Percent_Identity=34.7670250896057, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI21729882, Length=279, Percent_Identity=34.7670250896057, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI21729880, Length=279, Percent_Identity=34.7670250896057, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI21729878, Length=279, Percent_Identity=34.7670250896057, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1790846, Length=338, Percent_Identity=91.4201183431953, Blast_Score=652, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71981909, Length=243, Percent_Identity=32.5102880658436, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322415, Length=286, Percent_Identity=29.7202797202797, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28573464, Length=262, Percent_Identity=31.2977099236641, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37780; Mature: 37649

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRR
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHCCC
MEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASG
CCCCCCEEEEECCCCCCHHHHCCCHHEEHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCC
RNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITS
CCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHH
VRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERIDAEVISPDKTPDLPNFTETFARQS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCC
SWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAGRLQG
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHC
CQYRADKLQETCEALIATFPEQESELRELANWVAGAVR
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRR
CEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHCCC
MEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASG
CCCCCCEEEEECCCCCCHHHHCCCHHEEHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCC
RNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITS
CCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHH
VRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERIDAEVISPDKTPDLPNFTETFARQS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCC
SWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAGRLQG
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHC
CQYRADKLQETCEALIATFPEQESELRELANWVAGAVR
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA