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The map label for this gene is nuoL [H]

Identifier: 29141061

GI number: 29141061

Start: 620185

End: 622026

Strand: Direct

Name: nuoL [H]

Synonym: t0546

Alternate gene names: 29141061

Gene position: 620185-622026 (Clockwise)

Preceding gene: 29141060

Following gene: 29141062

Centisome position: 12.94

GC content: 57.93

Gene sequence:

>1842_bases
ATGAACATGCTTGCCTTAACCATTATTCTGCCATTGATTGGCTTTGTACTGCTGGCGTTCTCTCGCGGACGCTGGTCGGA
AAATCTCTCCGCGACCATTGGCGTGGGCTCCGTTGGTCTGGCGGCGTTGGTGACAGCGTTTGTCGGGATGGATTTCTTCG
CCAACGGCAAACAGGCGTTCAGCCAGCCGCTGTGGACGTGGATGTCGGTCGGTAACTTCAACATCGGTTTTAACCTGGTG
CTGGACGGCCTGTCGCTGACCATGCTCTCTGTGGTCACCGGCGTCGGCTTCCTGATCCACATGTTCGCTTCCTGGTACAT
GCGTGGAGAAGAGGGCTACTCCCGCTTCTTCGCTTATACCAACCTGTTTATCGCCAGCATGGTTGTTCTGGTGCTGTCCG
ATAACCTGCTGTTGATGTACCTCGGCTGGGAAGGCGTGGGCCTGTGCTCTTATCTGTTGATCGGCTTCTATTACAGCGAT
CCGAAGAATGGCGCGGCGGCAATGAAAGCCTTCGTGGTGACCCGTGTCGGTGACGTATTCCTCGCCTTCGCGCTGTTCAT
CCTCTACAACGAACTGGGCACGCTGAACTTCCGCGAAATGGTCGAGCTGGCGCCAGCGCACTTTGCTGACGGCAACAACA
TGCTGATGTGGGCGACGCTGATGCTGCTGGGCGGCGCGGTCGGTAAATCTGCGCAGCTACCGTTGCAGACCTGGCTTGCC
GACGCGATGGCCGGTCCGACGCCGGTCTCCGCGCTGATCCACGCCGCCACCATGGTTACCGCCGGTGTCTACCTGATCGC
ACGCACGCATGGCCTGTTCCTGATGACCCCGGAAATTCTGCATCTGGTGGGCATTATCGGGGCGATTACGCTGGTCATGG
CGGGTTTCGCCGCGCTGGTGCAGACCGACATCAAACGCGTGCTGGCCTATTCCACCATGAGCCAGATTGGCTACATGTTC
CTGGCGCTTGGCGTGCAGGCGTGGGATGCGGCGATTTTCCACCTGATGACGCACGCCTTCTTTAAAGCGCTGCTGTTCCT
GGCATCCGGCTCGGTAATTTTGGCCTGCCATCACGAACAGAACATCTTTAAGATGGGCGGTCTGCGTAAGTCCATTCCAC
TGGTGTATGCCTGCTTCCTGGTGGGGGGCGCGGCGCTGTCGGCGCTGCCGCTGGTCACTGCGGGCTTCTTCAGTAAGGAT
GAGATCCTGGCTGGCGCGATGGCGAACGGTCATATCAATCTGATGGTGGCGGGTCTGGTTGGCGCGTTCATGACCTCCCT
GTACACCTTCCGGATGATTTTCATCGTATTCCACGGTAAAGAACAAATTCATGCTCATGCAGGGAAGGGGATTACCCACC
ATCTGCCGCTGATTGTCCTGATGATTCTGTCTACCTTTGTTGGCGCGCTGATTGTGCCGCCTCTGCAGGGGGTGCTGCCG
CAGACAACTGAACTGGCGCATGGTCGTGTGTTGACCCTGGAAATTACCTCTGGCGTAGTGGCGATTGCCGGCATCCTGAT
TGCCGCATGGCTGTGGCTGGGTAAACGTACGCTGGTGACGTCGATCGCCAACAGCGCGCCGGGCCATCTGCTGGGGACCT
GGTGGTATAACGCCTGGGGCTTTGACTGGCTGTACGACAAAGTATTCGTCAAGCCATTCCTCGGTATCGCCTGGCTGCTG
AAGCGCGACCCGCTTAATGCGTTGATGAACATTCCGGCTATCCTTTCCCGTTTTGCAGGCAAAGGCCTGGTACTGAGCGA
GAACGGTTATTTGCGCTGGTATGTGGCATCCATGAGCATCGGCGCGGTTGTGGTGCTGGCGCTGCTGATGGTACTGCGTT
GA

Upstream 100 bases:

>100_bases
GCCTTGCGGCTGCGGAAGCGAGTATTGGACTTGCGCTGTTGCTGCAACTCCATCGCCGTCGCCAGAACCTGAACATCGAT
TCAGTAAGTGAGATGCGTGG

Downstream 100 bases:

>100_bases
GTTTGTTGGCTGGATGAACGACTGCCGGATGGCGCAGTGCTTATCCGGCCTACAAACCCAAAAATAATTTTTAGAATTCG
TTGAAAATCTGTTCCTGAAG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MNMLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLP
QTTELAHGRVLTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGHLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR

Sequences:

>Translated_613_residues
MNMLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLP
QTTELAHGRVLTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGHLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR
>Mature_613_residues
MNMLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLP
QTTELAHGRVLTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGHLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=381, Percent_Identity=39.1076115485564, Blast_Score=252, Evalue=9e-67,
Organism=Escherichia coli, GI1788614, Length=601, Percent_Identity=94.675540765391, Blast_Score=1155, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=420, Percent_Identity=34.0476190476191, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788827, Length=471, Percent_Identity=28.0254777070064, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788831, Length=362, Percent_Identity=28.7292817679558, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788613, Length=481, Percent_Identity=25.7796257796258, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI2367154, Length=289, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=399, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66425; Mature: 66425

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHH
SQPLWTWMSVGNFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPKNGAAAMKAFVVTRVGDVF
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLA
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALV
HHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEILAGAMANGHINLMVAGLV
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
GAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLP
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTTELAHGRVLTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGHLLGTWWYNAWG
CCHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHCCCC
FDWLYDKVFVKPFLGIAWLLKRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHH
GAVVVLALLMVLR
HHHHHHHHHHHHC
>Mature Secondary Structure
MNMLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHH
SQPLWTWMSVGNFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPKNGAAAMKAFVVTRVGDVF
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLA
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALV
HHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEILAGAMANGHINLMVAGLV
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
GAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLP
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTTELAHGRVLTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGHLLGTWWYNAWG
CCHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHCCCC
FDWLYDKVFVKPFLGIAWLLKRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHH
GAVVVLALLMVLR
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]