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The map label for this gene is xasA [C]

Identifier: 29141020

GI number: 29141020

Start: 578518

End: 579939

Strand: Direct

Name: xasA [C]

Synonym: t0505

Alternate gene names: 29141020

Gene position: 578518-579939 (Clockwise)

Preceding gene: 29141019

Following gene: 29141021

Centisome position: 12.07

GC content: 50.42

Gene sequence:

>1422_bases
ATGAGTAACACGAATTCTGGCTTACTTGGCATCAAAGACATTGTCTTTATGAATGTCATCGCTATTCTGAGTTTGCGGCA
AATCCCTAACGTGGCGCCTTACGGGGCATCGGCCATGTTGCTATGGGTGATAGCCGCATTCTGCTTGTTTTTTCCTTTAG
CGATGGTATGCGGCGAGCTGTCAACCGGCTGGCCGAAAGATGGCGGGATATTTGTCTGGATTAAAGAGGCATTTGGTAAA
CGTATTGCATGGATTGTCGTGGTTTGTTTTCTCTTTTCCTGCGTACTGTTTTTCCCATTAATGCTGCAATTCGGCTTTAC
CGCGTTGGGCTATATGATCGGCGGCGGCCTGGCGGAAAATAAAGCGTTTATCGGTATTGGTTCCGCGGTAATTTTCTGGC
TATTAACGCTGATGAATATCCGCGGGATGGAATGGACAAAAATTATTAATAGCATCAGCGCCTGGTGCGGCGTATTTATT
CCCTCCGCCATCCTCATTTTGCTGGCGGTGGTATGGCTATGTACCGGACACCAGATGCAGACGGACTACACTACAGCGAA
AAACTGGATTCCGGATCTCGGACACTGGGATACGATCGTTTTCTTATCCAGCATGATGTTTGCGTTTGCCGGACTGGAGG
TCGCCCCGATGATTGCCGGGCGTACCCGTAATCCACAGCGTGATTTTCCGCGAGCGATGGCCGTCTCTGCCGCCGTTATC
GTTGGGATCTATATGGTCGGCACCTGGGCGCTAAATACGCTTTTACCCGCCGGGAAAACCGACATCGTGGCAGGCGTCAT
GCAGGCTATGCATGCTGCTGCGGACACGCTGCATATGCCGTGGTTAATTCCTGTTATGGCCATCTGTATGTTTTTTGGCG
CTCTCGGGCAGATTAACTCCTGGCTGGTGGGGCCGATTTATATGCTCCAGGAAGCCTCGCGTGAAGATAATCTGCTGGGG
GACCGAATCGGCAAATTACATCCGGTGTGGAAAACGCCCGCCTTTGCCTTGACTATACAGGCGATTATTGTCACGGTCCT
GTGTTTTTCGACTTTTATTTCGCCAAGCGTTGCGGCGGCTTACTGGATGTTAACGGCGCTAACGACCATCACCTATTTTA
TTCCTTATCTGGTGATGTTCCCGGCGTTCTGGCGTTTACGTAAGACTCAGCCAGATACGCCAAGAAGTTTTAAAATTCCG
GGCAAGGTTTTACCGGCTATTTTACCCGCGCTGGGCTTTCTTTCTATCGCCTTTGCCGTTGCGCTGTTATTTATTCCGCC
TTCTCAAATTGATATGGGCGGATATTTCCAGTACGCCGGGAAAATTATTGGCGGAGCCGTGCTGGCGGTTGTCGTCGCGG
AGTACATTTACCATCGGGCGCAGAAACGTAATGCCCGTTTAAGCATGGCGGGAGGAAAATAA

Upstream 100 bases:

>100_bases
CATTTATTAATACTGTTTTGGGCTTCAGTTTCATGCTGAAGCCCGTCGTCAGATGATAAGAAGAGGGCAGTGATGCCTGA
ATGCATAACAGGAGATGGCC

Downstream 100 bases:

>100_bases
AATGTATATGCCAGTTCTGGAAATAAATCTACGCAAGCTGGAAGAAAACGCACGCACGGAAAAAGCTCTGCTGGCAAGCA
GCGGTATTGACGTGATGGCT

Product: amino acid transporter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSNTNSGLLGIKDIVFMNVIAILSLRQIPNVAPYGASAMLLWVIAAFCLFFPLAMVCGELSTGWPKDGGIFVWIKEAFGK
RIAWIVVVCFLFSCVLFFPLMLQFGFTALGYMIGGGLAENKAFIGIGSAVIFWLLTLMNIRGMEWTKIINSISAWCGVFI
PSAILILLAVVWLCTGHQMQTDYTTAKNWIPDLGHWDTIVFLSSMMFAFAGLEVAPMIAGRTRNPQRDFPRAMAVSAAVI
VGIYMVGTWALNTLLPAGKTDIVAGVMQAMHAAADTLHMPWLIPVMAICMFFGALGQINSWLVGPIYMLQEASREDNLLG
DRIGKLHPVWKTPAFALTIQAIIVTVLCFSTFISPSVAAAYWMLTALTTITYFIPYLVMFPAFWRLRKTQPDTPRSFKIP
GKVLPAILPALGFLSIAFAVALLFIPPSQIDMGGYFQYAGKIIGGAVLAVVVAEYIYHRAQKRNARLSMAGGK

Sequences:

>Translated_473_residues
MSNTNSGLLGIKDIVFMNVIAILSLRQIPNVAPYGASAMLLWVIAAFCLFFPLAMVCGELSTGWPKDGGIFVWIKEAFGK
RIAWIVVVCFLFSCVLFFPLMLQFGFTALGYMIGGGLAENKAFIGIGSAVIFWLLTLMNIRGMEWTKIINSISAWCGVFI
PSAILILLAVVWLCTGHQMQTDYTTAKNWIPDLGHWDTIVFLSSMMFAFAGLEVAPMIAGRTRNPQRDFPRAMAVSAAVI
VGIYMVGTWALNTLLPAGKTDIVAGVMQAMHAAADTLHMPWLIPVMAICMFFGALGQINSWLVGPIYMLQEASREDNLLG
DRIGKLHPVWKTPAFALTIQAIIVTVLCFSTFISPSVAAAYWMLTALTTITYFIPYLVMFPAFWRLRKTQPDTPRSFKIP
GKVLPAILPALGFLSIAFAVALLFIPPSQIDMGGYFQYAGKIIGGAVLAVVVAEYIYHRAQKRNARLSMAGGK
>Mature_472_residues
SNTNSGLLGIKDIVFMNVIAILSLRQIPNVAPYGASAMLLWVIAAFCLFFPLAMVCGELSTGWPKDGGIFVWIKEAFGKR
IAWIVVVCFLFSCVLFFPLMLQFGFTALGYMIGGGLAENKAFIGIGSAVIFWLLTLMNIRGMEWTKIINSISAWCGVFIP
SAILILLAVVWLCTGHQMQTDYTTAKNWIPDLGHWDTIVFLSSMMFAFAGLEVAPMIAGRTRNPQRDFPRAMAVSAAVIV
GIYMVGTWALNTLLPAGKTDIVAGVMQAMHAAADTLHMPWLIPVMAICMFFGALGQINSWLVGPIYMLQEASREDNLLGD
RIGKLHPVWKTPAFALTIQAIIVTVLCFSTFISPSVAAAYWMLTALTTITYFIPYLVMFPAFWRLRKTQPDTPRSFKIPG
KVLPAILPALGFLSIAFAVALLFIPPSQIDMGGYFQYAGKIIGGAVLAVVVAEYIYHRAQKRNARLSMAGGK

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=391, Percent_Identity=25.0639386189258, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=391, Percent_Identity=25.0639386189258, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787768, Length=420, Percent_Identity=25.4761904761905, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI2367353, Length=355, Percent_Identity=23.943661971831, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51855; Mature: 51724

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure 
SNTNSGLLGIKDIVFMNVIAILSLRQIPNVAPYGASAMLLWVIAAFCLFFPLAMVCGEL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC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HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]