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The map label for this gene is lysA [H]

Identifier: 29141019

GI number: 29141019

Start: 577030

End: 578427

Strand: Direct

Name: lysA [H]

Synonym: t0504

Alternate gene names: 29141019

Gene position: 577030-578427 (Clockwise)

Preceding gene: 29141017

Following gene: 29141020

Centisome position: 12.04

GC content: 49.93

Gene sequence:

>1398_bases
ATGACTGACTCGATTATGCAGAATTACAACCAGCTACGTGAGCAGGTAATCAACGGCGATCGCCGTTTCCAGCACAAAGA
CGGTCATTTGTGTTTTGAAGGGGTCGATCTGGACGCTCTGGCGCGCCAGTACCCCACGCCGTTCTATGTGTTTTCTGAGC
CGGAGATTATTCGTAACATTCATGAAATCCAGCAGGCATTTGCGGCGCATAAAAATACCAAAACCTTCTTTGCGTCAAAA
ACCTGCTCGGTCATGGGGGTGTTGAAAGCCATTCGTGACGCCGGAATTTGCGCGGAGGCAAACTCACAATATGAGGTTCG
CAAGTGCCTGGAGATAGGCTTTCGCGGCGATCAGATCGTCTTCAACGGCGTGGTGAAAAAGCCTGCCGATCTGGAATATG
CCATCGCCAACGATCTGTATCTTATTAATGTTGATAGCCTGTATGAGCTGGAACATATTGATGCCATCTCTCGCAAGCTG
AAGAAAGTCGCCAATGTTTGCGTCCGCGTAGAGCCGAATGTTCCCTCGGCGACGCATGCGGAACTGGTTACCGCTTTCCA
TGCGAAGTCGGGTCTCGACCTGGAACAGGCGGAAGAAACCTGCCGCCGCATTCTGGCGATGCCTTATGTGCATTTACGCG
GCTTGCATATGCATGTGGGCGATCAGGTGCCGGAGTCAGAGCCTTTCGCAAAAGCGACTAAAGTGCTGGTGGATGAATCC
CGTCGCCTGGAAGAGGTGCTCGGTATTAAATTTGATTTGATCAACGTGGGCGGCGGAATTCCGGTTCCCTATAAATATGA
CGACGAGAATGGCGACCCGTTAAAAGATAATATGTATGCCGGTATTACCGCCCAGGATTTTGCCGATGCGGTCATTCGCG
AAGTGCATAAATGGCGTACCGATGTGGAAATATGTATTGAACCGGGACGTAAAGTGACCGGGTCGGCGGCGGTTTTACTG
ACGGAAGTCTCCTGCGAAAAACGTAAAACAAATTACGATCTTAACGGCAATGTGGAATGCCACGTTGAATGGAAATTTGT
CGATGCTGGTTACAGCGTACTCTCTGATAGCCAGCATTTTGACTGGTTCTTTTATGTCTATAACGCCTCTCGCATGACGG
CAGCGCACGACGCCTGGATAAAATTAGCCGGGCCGCTGTGTGATGGCGGGGATTATTTCCACATGGGAGTGAAAGGCGAA
GAGTTTTTACTGCCGAAGGAGACTCATGTTGGCGATATTGTCGCGTTTCTTGATGCCGGGGCATACACCATTGAAAGTCA
AACCGTTTATAACAACCGTCCGCGCACGGGGGTGGTGATGATCGATAAAAATGGTGAGACGCGTCTGATTCGTCGGGAAG
ACAGTTACGAAGATATGGTCAAGTACGACATTTATTAA

Upstream 100 bases:

>100_bases
ATAAATAATTGATTATTTTGATAAAAAATAGTGGCATGCCTTTTGCTTTATCCCTGTAAAGAATGCGGATTTTTACCATA
AACATTAAGCAGAGGGCGTT

Downstream 100 bases:

>100_bases
TACTGTTTTGGGCTTCAGTTTCATGCTGAAGCCCGTCGTCAGATGATAAGAAGAGGGCAGTGATGCCTGAATGCATAACA
GGAGATGGCCATGAGTAACA

Product: amino acid decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNIHEIQQAFAAHKNTKTFFASK
TCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIVFNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKL
KKVANVCVRVEPNVPSATHAELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDES
RRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRTDVEICIEPGRKVTGSAAVLL
TEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHFDWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGE
EFLLPKETHVGDIVAFLDAGAYTIESQTVYNNRPRTGVVMIDKNGETRLIRREDSYEDMVKYDIY

Sequences:

>Translated_465_residues
MTDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNIHEIQQAFAAHKNTKTFFASK
TCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIVFNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKL
KKVANVCVRVEPNVPSATHAELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDES
RRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRTDVEICIEPGRKVTGSAAVLL
TEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHFDWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGE
EFLLPKETHVGDIVAFLDAGAYTIESQTVYNNRPRTGVVMIDKNGETRLIRREDSYEDMVKYDIY
>Mature_464_residues
TDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNIHEIQQAFAAHKNTKTFFASKT
CSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIVFNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKLK
KVANVCVRVEPNVPSATHAELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDESR
RLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRTDVEICIEPGRKVTGSAAVLLT
EVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHFDWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGEE
FLLPKETHVGDIVAFLDAGAYTIESQTVYNNRPRTGVVMIDKNGETRLIRREDSYEDMVKYDIY

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=434, Percent_Identity=26.7281105990783, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 52612; Mature: 52481

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNI
CCCHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCHHHHHHHCCCCEEEECCCHHHHHH
HEIQQAFAAHKNTKTFFASKTCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIV
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCEEE
FNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKLKKVANVCVRVEPNVPSATHA
EECCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHH
ELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDES
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHH
RRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRT
HHHHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
DVEICIEPGRKVTGSAAVLLTEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHF
CEEEEECCCCCCCCCEEEEEEECCHHHHCCCCCCCCCEEEEEEEEEEECCHHHHCCCCCC
DWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGEEFLLPKETHVGDIVAFLDAG
EEEEEEEECCCCCCHHHCEEEEECCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHCCC
AYTIESQTVYNNRPRTGVVMIDKNGETRLIRREDSYEDMVKYDIY
CEEEECCEEECCCCCEEEEEEECCCCEEEEECCCCHHHHHEECCC
>Mature Secondary Structure 
TDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNI
CCHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCHHHHHHHCCCCEEEECCCHHHHHH
HEIQQAFAAHKNTKTFFASKTCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIV
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCEEE
FNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKLKKVANVCVRVEPNVPSATHA
EECCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHH
ELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDES
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHH
RRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRT
HHHHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
DVEICIEPGRKVTGSAAVLLTEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHF
CEEEEECCCCCCCCCEEEEEEECCHHHHCCCCCCCCCEEEEEEEEEEECCHHHHCCCCCC
DWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGEEFLLPKETHVGDIVAFLDAG
EEEEEEEECCCCCCHHHCEEEEECCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHCCC
AYTIESQTVYNNRPRTGVVMIDKNGETRLIRREDSYEDMVKYDIY
CEEEECCEEECCCCCEEEEEEECCCCEEEEECCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]