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The map label for this gene is fixC

Identifier: 29140620

GI number: 29140620

Start: 90269

End: 91555

Strand: Direct

Name: fixC

Synonym: t0078

Alternate gene names: 29140620

Gene position: 90269-91555 (Clockwise)

Preceding gene: 29140619

Following gene: 29140621

Centisome position: 1.88

GC content: 55.48

Gene sequence:

>1287_bases
ATGTCCGAAGATATCTTTGATGCCATCATCGTGGGTGCAGGTCTGGCCGGTTCGGTTGCGGCGCTGGTGCTTGCTCGCGA
AGGTGCACAGGTGCTGGTTATCGAGCGCGGCAATTCTGCTGGCGCGAAGAATGTCACCGGTGGGCGTTTGTATGCACATA
GCCTGGAACGCATCATTCCCGGCTTTGCGGATCAGGCCCCCATTGAACGCATGATCACCCACGAAAAACTCGCCTTTATG
ACCGACAACGGGGCGATGACTATCGACTACTGCAATGGTGAAGATGCTTCAGCGTCGCAGGTTTCTTATTCCGTTTTGCG
TAGTAAATTTGACGCCTGGCTGATGGAGCAGGCCGAAGAGGCGGGGGCGCAACTGATCACTGGTATTCGCGTGGATAACG
TTGTTCAGCGTGATGGCAAAGTCGTGGGCGTGGAAGCCGATGGCGATATTCTGGAAGCCAAAGTCGTAATCCTCGCTGAC
GGGGTGAATTCTCTGCTGGCTGAAAAGCTGGGCATGGCCAAGCGTGTTGAGGCATCGCATGTTGCCGTCGGTGTGAAGGA
ACTGATCGAATTGCCGAAGTCGGTCATTGAAGATCGTTTCCAGCTACAGGGCAACGAAGGTGCCGCCTGTCTGTTTGCCG
GGGCGCCAACCGATGGTCTGATGGGCGGTGGCTTCCTGTATACGAATGAAACAACCCTTTCCCTAGGGCTGGTCTGCGGT
CTTCATCATCTGAAAGACGCGAAAAAATCGGTCCCGCAAATGCTGGAAGATTTCAAACAGCATCCGGCCGTTGCGCCGCT
GATCGCCGGTGGCAAGCTGGTGGAATATGCCGCACACGTTGTACCCGAGGCGGGAATGAATATGCAGCCTGAACTGGTGG
GCGATGGTGTACTGATTGCCGGAGACGCTGCCGGCATGTGTATGAACCTCGGCTTTACCATCCGGGGTATGGATCTCGCC
ATATCCGCAGGCGAAGCGGCGGCGAAGACGGTGCTTTCGGCGATGAAGCGCGACGATTTTAGCAAGCAGTCGTTGGGTGA
ATACCGTCAGCATCTGGACGAAGGTCCGATGCGCGATATGCGCATGTATCAGAAACTGCCAGCTTTTCTTGATAATCCCC
GCATGTTTACCGCCTATCCCGAAATGGCGGTCAGTATCGCGCGCGACCTGTTCACCGTGGATGGCTCCGCGCCGGTGCCC
ATGCGTAAAAAAATCCTGCGCCATGCGAAGAAAGTGGGCTTCATCAACCTGATGAAAGATGGCCTGAAAGGAGTGACCGT
ATTATGA

Upstream 100 bases:

>100_bases
GGCGATGCGCTGAAGATCCTGCCTGCGCTGACGGCTGCCTTAGCGCGATAAACCATTTCGGGCAGGATACGAAGGTATCC
TGCCGCTGACAGGAGTACGT

Downstream 100 bases:

>100_bases
CATCTCCCGTCAATGTGGACGTCAAATTGGGCGTCAATAAGTTCAATGTGGATGAAGATAGCCCGCACATCATTCTCAAA
ACCGATCCTGATAAACAGGC

Product: oxidoreductase FixC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFM
TDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILAD
GVNSLLAEKLGMAKRVEASHVAVGVKELIELPKSVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
ISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVSIARDLFTVDGSAPVP
MRKKILRHAKKVGFINLMKDGLKGVTVL

Sequences:

>Translated_428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFM
TDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILAD
GVNSLLAEKLGMAKRVEASHVAVGVKELIELPKSVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
ISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVSIARDLFTVDGSAPVP
MRKKILRHAKKVGFINLMKDGLKGVTVL
>Mature_427_residues
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFMT
DNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADG
VNSLLAEKLGMAKRVEASHVAVGVKELIELPKSVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCGL
HHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAI
SAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVSIARDLFTVDGSAPVPM
RKKILRHAKKVGFINLMKDGLKGVTVL

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family

Homologues:

Organism=Homo sapiens, GI119703746, Length=382, Percent_Identity=26.9633507853403, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1786227, Length=428, Percent_Identity=89.018691588785, Blast_Score=772, Evalue=0.0,
Organism=Escherichia coli, GI1787991, Length=429, Percent_Identity=60.6060606060606, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082155, Length=431, Percent_Identity=41.5313225058005, Blast_Score=325, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI25144720, Length=444, Percent_Identity=25.9009009009009, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324932, Length=376, Percent_Identity=26.3297872340426, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652256, Length=365, Percent_Identity=29.041095890411, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FIXC_SALTI (Q8Z9K9)

Other databases:

- EMBL:   AL627265
- EMBL:   AE014613
- RefSeq:   NP_454687.1
- RefSeq:   NP_803962.1
- ProteinModelPortal:   Q8Z9K9
- GeneID:   1067635
- GeneID:   1246589
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0078
- KEGG:   sty:STY0087
- HOGENOM:   HBG295204
- OMA:   VNIARDL
- ProtClustDB:   PRK10157
- BioCyc:   SENT209261:T0078-MONOMER
- BioCyc:   SENT220341:STY0087-MONOMER
- GO:   GO:0006810
- InterPro:   IPR006076
- InterPro:   IPR003042
- PRINTS:   PR00420

Pfam domain/function: PF01266 DAO

EC number: 1.5.5.-

Molecular weight: Translated: 45687; Mature: 45556

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIP
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADQAPIERMITHEKLAFMTDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADGVNSLLAEKLGMAKRVEASH
HHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHHHHHHH
VAVGVKELIELPKSVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHH
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GDAAGMCMNLGFTIRGMDLAISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
RMYQKLPAFLDNPRMFTAYPEMAVSIARDLFTVDGSAPVPMRKKILRHAKKVGFINLMKD
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHH
GLKGVTVL
CCCCCCCC
>Mature Secondary Structure 
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIP
CHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADQAPIERMITHEKLAFMTDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADGVNSLLAEKLGMAKRVEASH
HHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHHHHHHH
VAVGVKELIELPKSVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHH
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GDAAGMCMNLGFTIRGMDLAISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
RMYQKLPAFLDNPRMFTAYPEMAVSIARDLFTVDGSAPVPMRKKILRHAKKVGFINLMKD
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHH
GLKGVTVL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504