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The map label for this gene is mdtG [H]

Identifier: 28379728

GI number: 28379728

Start: 3007514

End: 3008737

Strand: Direct

Name: mdtG [H]

Synonym: lp_3392

Alternate gene names: 28379728

Gene position: 3007514-3008737 (Clockwise)

Preceding gene: 28379727

Following gene: 28379732

Centisome position: 90.91

GC content: 48.61

Gene sequence:

>1224_bases
GTGAAGGGCGCATTGCCAGGCTGGCGCCGGAATCTCGCTGTTCTCTGGCTAGGAACATTTATCGCCGGAATGGGATTTTC
TGAAGTCATGCCATTCTTATCATTATACGTTGGTCAAATGGGGGATTTCTCCAAAAACGAACTCACGATGTATAGTGGTA
TTACATACGCAGTGACTTTTTTTGTCGTTGCTGTTGTCTCACCATTATGGGGTAAACTCGCTGACCGGCGTGGTCGCAAA
ATCATGCTGCTGCGTTCTTCGCTTGGGATGGCCTTTGTTATCGGTGCGATGGGATTTGTCCATAACATTTGGATACTCAT
TCTACTTCGGTTCTTACAAGGCCTGTGTGCCGGCTACATTCCCAATGCTAGCGCCCTAATCGCCACCGAAACTCCCAAGG
AAAGTAGTGGGACCGCAATCGGTATCCTAACAACTGGCTACGTGTCTGGTAACTTGATCGGCCCGATTCTCGGTGGCGTA
CTCGCCCAAGTTTTCTCTATTCGTTTGACTTTCATTATCACCGGAATTTTGCTACTGATCGTCTTCGTATTGAGTCTGAC
ACTCGTCCACGAAAGCTTTAAACCCAGCGACGCGCCGATTGCTAAACGTGACGGCAGTCTACTCAGCCAATTTAAAAATC
CAACGTTGATTATCACACTGCTCGTCTCCACGATGATTATTCAAATGGGGAATAATTCCATCACGCCCATTATTAGTCTA
TATGTCAAAGAACTGATGCATAACGTCGGCCCAATCACCGTCGTTGCTGGAATCATTGCCGCTCTACCCGGAATTTCGAC
GCTATTATCGGCGCCGCGACTCGGACGGCTCGGTGATCACCGGGGGGCTGACCGTATCCTTGTCTTTGGTTTCGTCTTTG
CCATCCTGATGTACTTTCCACAAGGCTTCGTCTCCAGTGTGTGGACATTAGGGCTATTGCGCTTCATGATTGGGATCTCT
GACGGGGCCCTCTTTCCAACGGTGCAAACATTATTATCCAAAAATACACCCCGCGAGTTAACAGGCACTATTTTCAGTTG
GAATCAATCTTTCCAAGCGGCTGGCAGCATGCTCGGCTCCTTACTTGGTGGCGCCGTCTCCGGCTGGTTCGATTACAACG
GTGTCTTTATCTTCACCGCCTTGTCATTACTGCTTAACTTCATCGGCGTACTGATCTTTATACCAAGTATGCGGCACCCA
TTTGCAAAACACTCGGTTGATTAA

Upstream 100 bases:

>100_bases
CAGTCGCCATTCAATCCTATTTAACTAAGTTAGTTAATTGCACAAAACTTAAATTCGCATTAAAATAATCTTAATAAGTT
AATTAAGGAAGTGACAGATT

Downstream 100 bases:

>100_bases
CCGCGCTATTTATCAAGTTCAAAAGCTATCAGCTTAGTCCCGGAGATCGGATCAGGATGCGGACCGGCTGACAAACACTA
ATCCGACTAGCATATTTTAA

Product: transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTFFVVAVVSPLWGKLADRRGRK
IMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYIPNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGV
LAQVFSIRLTFIITGILLLIVFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISL
YVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFPQGFVSSVWTLGLLRFMIGIS
DGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGSLLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHP
FAKHSVD

Sequences:

>Translated_407_residues
MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTFFVVAVVSPLWGKLADRRGRK
IMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYIPNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGV
LAQVFSIRLTFIITGILLLIVFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISL
YVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFPQGFVSSVWTLGLLRFMIGIS
DGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGSLLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHP
FAKHSVD
>Mature_407_residues
MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTFFVVAVVSPLWGKLADRRGRK
IMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYIPNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGV
LAQVFSIRLTFIITGILLLIVFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISL
YVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFPQGFVSSVWTLGLLRFMIGIS
DGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGSLLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHP
FAKHSVD

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=381, Percent_Identity=46.7191601049869, Blast_Score=348, Evalue=5e-97,
Organism=Escherichia coli, GI87082404, Length=369, Percent_Identity=24.9322493224932, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25146993, Length=381, Percent_Identity=23.6220472440945, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43962; Mature: 43962

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTF
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHHHH
FVVAVVSPLWGKLADRRGRKIMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYI
HHHHHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGVLAQVFSIRLTFIITGILLLI
CCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISL
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
YVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFP
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QGFVSSVWTLGLLRFMIGISDGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHPFAKHSVD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTF
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHHHH
FVVAVVSPLWGKLADRRGRKIMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYI
HHHHHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGVLAQVFSIRLTFIITGILLLI
CCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISL
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
YVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFP
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QGFVSSVWTLGLLRFMIGISDGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHPFAKHSVD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA