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The map label for this gene is mntH2 [H]

Identifier: 28379425

GI number: 28379425

Start: 2662015

End: 2663607

Strand: Direct

Name: mntH2 [H]

Synonym: lp_2992

Alternate gene names: 28379425

Gene position: 2662015-2663607 (Clockwise)

Preceding gene: 28379408

Following gene: 28379426

Centisome position: 80.47

GC content: 45.2

Gene sequence:

>1593_bases
TTGAGCGAAAAGACGAACACCCCAAACCGGAAGCATAAATTGATTGAATATGCTAACGGCCCCTCACTAGAGGAAATTAA
CGGTACCATCGAGGTTCCCAAGAATCTGAACTTCTGGAAAACCCTCTTTGCGTATTCAGGTCCTGGTGCCTTAGTTGCGG
TAGGTTACATGGATCCCGGTAACTGGTCAACTTCCATCACCGGTGGTCAAAACTACCAATACATGCTAATGTCTGTCATC
TTGATATCAAGTTTGATTGCGATGCTACTACAATACATGGCGGCTAAACTTGGTATCGTGAGTCAGATGGATCTGGCCCA
AGCGATTCGGGCGCGGACGAGTAAATCACTCGGAATCGTCTTGTGGATTTTAACCGAATTAGCCATCATGGCGACCGACA
TTGCCGAAGTTATCGGTGCTGCGATTGCCCTCTATTTATTATTCAACATTCCGTTAGTCATTGCGGTGTTTATTACCGTG
CTTGACGTTTTAGTTTTGCTATTATTGACCAAAATCGGTTTTCGGAAAATCGAAGCCATCGTGGTTTGTTTGATTTTAGT
TATCTTATTCGTATTCGTTTATCAAGTCGCACTGTCCAACCCTGATTGGGGCGGTGTGATCAAGGGCCTAGTCCCAACCG
CTGACACTTTCTCGACAAGTCGTTCAGTAAACGGTATGACGCCACTTTCTGGTGCTTTAGGGATTATCGGTGCCACCGTC
ATGCCACACAATTTGTACTTACATTCAGCCATCTCACAAACGCGGAAGATTGACCACAACGATGAGGAAGATGTCGCGCG
GACCGTTAAATTCGCTGCTTGGGATTCCAATATCCAACTTTCATTCGCTTTCGTGGTTAATTCACTATTATTGATTATGG
GCGTTGCCGTCTTTAAGAGTGGCGCTGTTAAAGATCCTTCATTCTTCGGTCTTTATGAAGCATTATCCAATACATCAATG
TTAAGCAATGGTATTTTAATCAGTGTTGCTAAATCTGGGGCGCTCTCAGCCCTCTTCGCCATCGCGTTACTGGCTTCTGG
GCAAAACTCCACAATTACCGGTACGTTAACTGGGCAAGTCATCATGGAAGGGTTCGTCCACATGCGGATGCCACTCTGGT
TACGGCGGTTAGTGACCCGGTTGATCTCCGTTATTCCCGTCCTCATTTGCGTGCTATTAACTAGTGGTAAGAGTGCAATC
GACGAGCATACTGCATTGAATAATCTGATGAATAACTCACAAGTCTTTCTGGCTTTCGCCCTTCCATTCTCCATGTTGCC
ACTATTAATGATGACTGACAGCGCGGCAGAAATGGGCAAACGATTCAAAAACTCACTTTGGATCAAAGGTTTAGGTTGGT
TATCCGTCATCGGTTTGACTTTCTTAAACTTACTCGGTCTACCAGATTCAATCTTAGGCTTCTTTGGCGATAATCCTTCA
GCTGGCGAACAGACTTTTTCTAAAATTCTAGCCTACCTTTTGATTGCCGCTATCTTAGCCCTACTTGTCTGGACCGTCTT
CGACCTACAACGCGGTAACAAACGTTACGTTGAACAGCAACTTGCTGCAGCAGCAAAGGAGGCCAACAAATAA

Upstream 100 bases:

>100_bases
ATTTTGTAGGCATACCTAAAAAAGTATTTCCATTTACTTTTATTTATTGTACAATGACAACGGCTCAAAGATTTAGAGAT
ATAGAAAGGTGGTCTTTTAA

Downstream 100 bases:

>100_bases
TGGCGACTAAATTCAACCGGATTCTCGTTGGTGTTGATGATTCTGCCGATGCTTTACTTGCTTTTGACTATGCAATCCAT
CAAGCGAAGCAAGATGGTGC

Product: manganese transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSEKTNTPNRKHKLIEYANGPSLEEINGTIEVPKNLNFWKTLFAYSGPGALVAVGYMDPGNWSTSITGGQNYQYMLMSVI
LISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFNIPLVIAVFITV
LDVLVLLLLTKIGFRKIEAIVVCLILVILFVFVYQVALSNPDWGGVIKGLVPTADTFSTSRSVNGMTPLSGALGIIGATV
MPHNLYLHSAISQTRKIDHNDEEDVARTVKFAAWDSNIQLSFAFVVNSLLLIMGVAVFKSGAVKDPSFFGLYEALSNTSM
LSNGILISVAKSGALSALFAIALLASGQNSTITGTLTGQVIMEGFVHMRMPLWLRRLVTRLISVIPVLICVLLTSGKSAI
DEHTALNNLMNNSQVFLAFALPFSMLPLLMMTDSAAEMGKRFKNSLWIKGLGWLSVIGLTFLNLLGLPDSILGFFGDNPS
AGEQTFSKILAYLLIAAILALLVWTVFDLQRGNKRYVEQQLAAAAKEANK

Sequences:

>Translated_530_residues
MSEKTNTPNRKHKLIEYANGPSLEEINGTIEVPKNLNFWKTLFAYSGPGALVAVGYMDPGNWSTSITGGQNYQYMLMSVI
LISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFNIPLVIAVFITV
LDVLVLLLLTKIGFRKIEAIVVCLILVILFVFVYQVALSNPDWGGVIKGLVPTADTFSTSRSVNGMTPLSGALGIIGATV
MPHNLYLHSAISQTRKIDHNDEEDVARTVKFAAWDSNIQLSFAFVVNSLLLIMGVAVFKSGAVKDPSFFGLYEALSNTSM
LSNGILISVAKSGALSALFAIALLASGQNSTITGTLTGQVIMEGFVHMRMPLWLRRLVTRLISVIPVLICVLLTSGKSAI
DEHTALNNLMNNSQVFLAFALPFSMLPLLMMTDSAAEMGKRFKNSLWIKGLGWLSVIGLTFLNLLGLPDSILGFFGDNPS
AGEQTFSKILAYLLIAAILALLVWTVFDLQRGNKRYVEQQLAAAAKEANK
>Mature_529_residues
SEKTNTPNRKHKLIEYANGPSLEEINGTIEVPKNLNFWKTLFAYSGPGALVAVGYMDPGNWSTSITGGQNYQYMLMSVIL
ISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFNIPLVIAVFITVL
DVLVLLLLTKIGFRKIEAIVVCLILVILFVFVYQVALSNPDWGGVIKGLVPTADTFSTSRSVNGMTPLSGALGIIGATVM
PHNLYLHSAISQTRKIDHNDEEDVARTVKFAAWDSNIQLSFAFVVNSLLLIMGVAVFKSGAVKDPSFFGLYEALSNTSML
SNGILISVAKSGALSALFAIALLASGQNSTITGTLTGQVIMEGFVHMRMPLWLRRLVTRLISVIPVLICVLLTSGKSAID
EHTALNNLMNNSQVFLAFALPFSMLPLLMMTDSAAEMGKRFKNSLWIKGLGWLSVIGLTFLNLLGLPDSILGFFGDNPSA
GEQTFSKILAYLLIAAILALLVWTVFDLQRGNKRYVEQQLAAAAKEANK

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI295293167, Length=455, Percent_Identity=32.7472527472527, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI109255241, Length=422, Percent_Identity=31.9905213270142, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI295293175, Length=440, Percent_Identity=33.1818181818182, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI295293173, Length=440, Percent_Identity=33.1818181818182, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI10835169, Length=440, Percent_Identity=33.1818181818182, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI295293178, Length=440, Percent_Identity=33.1818181818182, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI295293171, Length=455, Percent_Identity=32.967032967033, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI295293169, Length=455, Percent_Identity=32.967032967033, Blast_Score=210, Evalue=3e-54,
Organism=Escherichia coli, GI1788736, Length=441, Percent_Identity=31.9727891156463, Blast_Score=198, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71999499, Length=450, Percent_Identity=33.1111111111111, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI193210616, Length=462, Percent_Identity=33.3333333333333, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17569473, Length=397, Percent_Identity=35.0125944584383, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI71993856, Length=259, Percent_Identity=37.0656370656371, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324450, Length=430, Percent_Identity=32.7906976744186, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323062, Length=400, Percent_Identity=39, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321841, Length=425, Percent_Identity=35.7647058823529, Blast_Score=206, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24648607, Length=446, Percent_Identity=32.0627802690583, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281362176, Length=446, Percent_Identity=32.0627802690583, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24648609, Length=446, Percent_Identity=32.0627802690583, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45553443, Length=440, Percent_Identity=32.5, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 57461; Mature: 57330

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTNTPNRKHKLIEYANGPSLEEINGTIEVPKNLNFWKTLFAYSGPGALVAVGYMDPG
CCCCCCCCCHHHHHHHHCCCCCHHHCCCCEECCCCCHHHHHHHHCCCCCCEEEEEECCCC
NWSTSITGGQNYQYMLMSVILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LWILTELAIMATDIAEVIGAAIALYLLFNIPLVIAVFITVLDVLVLLLLTKIGFRKIEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVCLILVILFVFVYQVALSNPDWGGVIKGLVPTADTFSTSRSVNGMTPLSGALGIIGATV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHH
MPHNLYLHSAISQTRKIDHNDEEDVARTVKFAAWDSNIQLSFAFVVNSLLLIMGVAVFKS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHCC
GAVKDPSFFGLYEALSNTSMLSNGILISVAKSGALSALFAIALLASGQNSTITGTLTGQV
CCCCCCHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHH
IMEGFVHMRMPLWLRRLVTRLISVIPVLICVLLTSGKSAIDEHTALNNLMNNSQVFLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEH
LPFSMLPLLMMTDSAAEMGKRFKNSLWIKGLGWLSVIGLTFLNLLGLPDSILGFFGDNPS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
AGEQTFSKILAYLLIAAILALLVWTVFDLQRGNKRYVEQQLAAAAKEANK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEKTNTPNRKHKLIEYANGPSLEEINGTIEVPKNLNFWKTLFAYSGPGALVAVGYMDPG
CCCCCCCCHHHHHHHHCCCCCHHHCCCCEECCCCCHHHHHHHHCCCCCCEEEEEECCCC
NWSTSITGGQNYQYMLMSVILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LWILTELAIMATDIAEVIGAAIALYLLFNIPLVIAVFITVLDVLVLLLLTKIGFRKIEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVCLILVILFVFVYQVALSNPDWGGVIKGLVPTADTFSTSRSVNGMTPLSGALGIIGATV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHH
MPHNLYLHSAISQTRKIDHNDEEDVARTVKFAAWDSNIQLSFAFVVNSLLLIMGVAVFKS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHCC
GAVKDPSFFGLYEALSNTSMLSNGILISVAKSGALSALFAIALLASGQNSTITGTLTGQV
CCCCCCHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHH
IMEGFVHMRMPLWLRRLVTRLISVIPVLICVLLTSGKSAIDEHTALNNLMNNSQVFLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEH
LPFSMLPLLMMTDSAAEMGKRFKNSLWIKGLGWLSVIGLTFLNLLGLPDSILGFFGDNPS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
AGEQTFSKILAYLLIAAILALLVWTVFDLQRGNKRYVEQQLAAAAKEANK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA