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The map label for this gene is panE2 [C]

Identifier: 28379272

GI number: 28379272

Start: 2477881

End: 2478900

Strand: Direct

Name: panE2 [C]

Synonym: lp_2788

Alternate gene names: 28379272

Gene position: 2477881-2478900 (Clockwise)

Preceding gene: 28379269

Following gene: 28379273

Centisome position: 74.9

GC content: 48.53

Gene sequence:

>1020_bases
ATGCATTTTACAGTACTCGGCGCAGGCGCCATGGGATTACGTTACGGTGTGTTATTACAAGAAGCAGGCAATCAAGTTGA
TTTTGTGGATACTTGGCAAGCAAATGTTGATCAAATTCATCGTCAAGGTGGCGTCTACGTGTCGCGCGATCACCAGAATC
GACACTTAGTTCCCGTCAAAGTCTCAACTCCCGAAGATTATCACGATGATCCCGACGTGTGGGTCGTATTTACTAAACAG
ATGCAACTTGCTGATTTTTTGACTCGGACGGCCCACGCTTTTAATGGTCGCCAGTACGTGCTCACTTGCATGAATGGGAT
GGGTCACGTTGAAAAATTATTACACTACTTCAAACCCGAAAAATTATTAGCTGGGACCGCACTAGTCGCTACGGTCTTAA
ACGGCCCTGGTGATGTCGACTTCATTGGAGCTCGCGGCGCCGGCACCATGAATCTCGCCAATTATACGGAACACCCTGAC
GAAATGACCCACCGAATCGTGACAGAATTAGATAAATGCCAATTCCACCCTAATTTAACAACGAACTTCCGCGGCACCTT
GCTGGCTAAAGTCGTCTTCAACTCAGTGGTCAACACCCTCTGTACCCTCTTTGAAATTACGATGGGCGAATTCGCGGCCT
ATCCAGGGGCTGATGAGCTGAGTCGTCAATTGATCGATGAAGCCTATGATGTCTGTGAGCGTGATGGTGTCACCATGTTG
AATACCCGCGCGGAAGAGCTCGCCTCTGTCAACTACGTCAGCAAAGTGGCTAATCCCCTCCACTACCCATCGATGTATCA
AGATATGTCTCATAATCGGCCAACTGAAGTCGACTATATCAATGGCTACCTCGTCAAGCTCGGCCAAAAGTACCATTACC
AAGCAAAAACGCACGCGTTTCTGACCCATCTGGTTCACTTAGCCGAAACCACCCGCCAAACCAGTGCCACAACTGAACAC
ACTACTGAACAAAATGCTCAGAACGCGACCGAACAGGCTAGTCAACAAGCAAGTGCGTAA

Upstream 100 bases:

>100_bases
TACCGGTGGTAACCCGCGCTCGCGTCCGGCAGACGACTTCGTCTGTCGGACGTTTTTATTTTCATTTATTAATAAATCAT
TTTAAAGGATGGTCATACAT

Downstream 100 bases:

>100_bases
CCGATTCCCCTTTTCTCAGCAAAATCATGTACAATGGAGGTTAAGTTGATTTTACTGAGGAGGCGGTTTGCTGTGCAAGT
CAGTCGGGAATTCAAAGGTA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVKVSTPEDYHDDPDVWVVFTKQ
MQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPEKLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPD
EMTHRIVTELDKCQFHPNLTTNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTML
NTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAFLTHLVHLAETTRQTSATTEH
TTEQNAQNATEQASQQASA

Sequences:

>Translated_339_residues
MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVKVSTPEDYHDDPDVWVVFTKQ
MQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPEKLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPD
EMTHRIVTELDKCQFHPNLTTNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTML
NTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAFLTHLVHLAETTRQTSATTEH
TTEQNAQNATEQASQQASA
>Mature_339_residues
MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVKVSTPEDYHDDPDVWVVFTKQ
MQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPEKLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPD
EMTHRIVTELDKCQFHPNLTTNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTML
NTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAFLTHLVHLAETTRQTSATTEH
TTEQNAQNATEQASQQASA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=318, Percent_Identity=26.7295597484277, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 37952; Mature: 37952

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVK
CEEEEEECCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCCEEEEEE
VSTPEDYHDDPDVWVVFTKQMQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPE
ECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHCCH
KLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPDEMTHRIVTELDKCQFHPNLT
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
TNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEE
NTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAF
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHCHHHHHHCCHHHHHHHHHHH
LTHLVHLAETTRQTSATTEHTTEQNAQNATEQASQQASA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVK
CEEEEEECCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCCEEEEEE
VSTPEDYHDDPDVWVVFTKQMQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPE
ECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHCCH
KLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPDEMTHRIVTELDKCQFHPNLT
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
TNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEE
NTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAF
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHCHHHHHHCCHHHHHHHHHHH
LTHLVHLAETTRQTSATTEHTTEQNAQNATEQASQQASA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]