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The map label for this gene is cah [H]

Identifier: 28379228

GI number: 28379228

Start: 2434792

End: 2435427

Strand: Direct

Name: cah [H]

Synonym: lp_2736

Alternate gene names: 28379228

Gene position: 2434792-2435427 (Clockwise)

Preceding gene: 28379211

Following gene: 28379229

Centisome position: 73.6

GC content: 48.11

Gene sequence:

>636_bases
ATGACATTTGATTATGCACACCAAACTGATTGGCCCATGACTAGTGGTCAACATCAGTCACCAATCGATATTCAAACACA
ACACGTTCAGTCTTCACAGCTATCCGCCATCAACTGGCGAGGCTTGTACCAAGCCAAAACGATTACGGGCGAAGCGACGA
CTTTGAAGGCTAGTGGAATTGGTGCCGCTTATTTGAACGACCGCGACTTTGCCTTTCAACAGATTCACTTTCATACGCCG
GCAGAACACTTAATCGATGGGCAAGCCGCACCAATCGAATGGCATCTCGTTCATCAAAGTGCTACCGGCCAGCTCGCCGT
CGTCGCCGTTTTTGGACGGATTGGCAAGCCTAATTCTAGTTTACAAGGCTTACTTGACCAGTTCACAGCCCAAACGAGCC
ATGAACTGACAACACCGGTCAACTTAACTGAGCTCCTCCCAGATACCGGGACGGTCTATCACTACTTGGGCTCATTGACG
ACGCCGCCACTAAGTGAAACCGTTGAATGGTATGTCTGTGCCGATACTGTCATGATTGGTGAACAACAATTAGCTGCTTA
TCAGCAATTATTTGCCGCTAATAACCGCAAGATTCAACCGTTAAACGATCGGCCAATCATTGCCGAACGTTTCTAA

Upstream 100 bases:

>100_bases
CTGACAAACAGCATCACAACCTTGGACCGATTAGCCATAAATTTCCATACTGGCACTAAATAAAAAATATTCACTGAATA
ATATAACGGAGGATCTTTCG

Downstream 100 bases:

>100_bases
ATAATTTTAATGGGGTGAGCTGATGCCTAAGAAAGTAATCTGGGGCTTGATTGCAAGTGGCCTATTTCTTTTATTGATCG
TCGGTCTCGGACTGACAACA

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGIGAAYLNDRDFAFQQIHFHTP
AEHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSSLQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLT
TPPLSETVEWYVCADTVMIGEQQLAAYQQLFAANNRKIQPLNDRPIIAERF

Sequences:

>Translated_211_residues
MTFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGIGAAYLNDRDFAFQQIHFHTP
AEHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSSLQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLT
TPPLSETVEWYVCADTVMIGEQQLAAYQQLFAANNRKIQPLNDRPIIAERF
>Mature_210_residues
TFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGIGAAYLNDRDFAFQQIHFHTPA
EHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSSLQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLTT
PPLSETVEWYVCADTVMIGEQQLAAYQQLFAANNRKIQPLNDRPIIAERF

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4502521, Length=237, Percent_Identity=32.0675105485232, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI38348436, Length=245, Percent_Identity=29.3877551020408, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI258679498, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI192447434, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI192447432, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI192447430, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4502517, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4885101, Length=247, Percent_Identity=29.5546558704453, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI62240989, Length=171, Percent_Identity=32.1637426900585, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4557395, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI6005723, Length=172, Percent_Identity=29.6511627906977, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI194097398, Length=212, Percent_Identity=29.2452830188679, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI169636420, Length=246, Percent_Identity=29.6747967479675, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI6912284, Length=240, Percent_Identity=29.5833333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4885099, Length=249, Percent_Identity=26.1044176706827, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI70167127, Length=237, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568715, Length=226, Percent_Identity=30.5309734513274, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17569163, Length=231, Percent_Identity=30.7359307359307, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569165, Length=227, Percent_Identity=30.8370044052863, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737413, Length=226, Percent_Identity=28.7610619469027, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358169, Length=239, Percent_Identity=30.5439330543933, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645604, Length=229, Percent_Identity=23.1441048034935, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 23399; Mature: 23268

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCEEEEEEECCCCEEEEECCC
GAAYLNDRDFAFQQIHFHTPAEHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSS
EEEEECCCCCEEEEEEECCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCHH
LQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLTTPPLSETVEWYVCADTVMIG
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCHHHCEEEEEEECEEEEC
EQQLAAYQQLFAANNRKIQPLNDRPIIAERF
HHHHHHHHHHHHCCCCEECCCCCCCEEECCC
>Mature Secondary Structure 
TFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGI
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCEEEEEEECCCCEEEEECCC
GAAYLNDRDFAFQQIHFHTPAEHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSS
EEEEECCCCCEEEEEEECCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCHH
LQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLTTPPLSETVEWYVCADTVMIG
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCHHHCEEEEEEECEEEEC
EQQLAAYQQLFAANNRKIQPLNDRPIIAERF
HHHHHHHHHHHHCCCCEECCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]