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The map label for this gene is gpd [H]

Identifier: 28379186

GI number: 28379186

Start: 2380421

End: 2381905

Strand: Direct

Name: gpd [H]

Synonym: lp_2681

Alternate gene names: 28379186

Gene position: 2380421-2381905 (Clockwise)

Preceding gene: 28379185

Following gene: 28379188

Centisome position: 71.95

GC content: 44.71

Gene sequence:

>1485_bases
ATGAGTAACGAAAAAATTGCCTTATTCACCATCTTTGGCGGTACTGGTGACCTCGCACAGCGTAAACTGTACCCGTCACT
ATTTAAGCTCTATCAAAAGGGCTATCTCAAGGACCACTTTGCCGTTATTGGGACGGCTCGGCGTCCTTGGACTGATGATC
ACTATCATGAAGTTATTAGTGACTCCCTAGCTGATCTGAATGCTGATCAGGAAACGGTGACGCAATTTGCGAGCCATTTT
TATTATCAATCGCATGACGTTACTGATGCTGAACATTACCGAACTTTGAAAAAATTATCAGAAAAGCTGGACGCCCAATA
TGGTTTACAAGGCAACCGGATCTTCTACTTAGCAATGGCACCAAACTTCTTCGGTACGATTGCCCAACACTTACGTTCCG
AAAATATTCTGACAGATAACGGTTTTAACCGCGTCATTATCGAAAAGCCTTTTGGTCATGATTATGAAAGTGCCAAGGAA
CTTAACGACCAATTAACGGCTACTTTTAACGAAAATCAGATTTATCGAATTGACCACTACCTTGGTAAAGAAATGATTCA
AAATATCACGGCCATTCGTTTTGGCAATAATATTTGGGAATCATTATGGAACAACCGTTACATCGACAATGTCCAAATTA
CGTTAAGTGAAAAACTGGGTGTCGAAGAACGGGCCGTTTACTATGATAACAGCGGTGCCTTGCGGGATATGGTCCAAAAT
CACATTTTGCAAATTTTGAGTCTGTTAACAATGGATCAACCAGTTGAATTCACTGAAAATGATATCGACGTGGAAAAGGT
CAAGGCTTTACGGAGCTTACGACCACTTAAACCAGAAGAAGTCGCAACCAACTTTGTCCGTGGTCAATACGGTGCCGGCG
ATGATGCTAAAGCTTACCGCGACGAAGATAAGATTTCATCAGATTCTAACACCGATACTTTCGTCGCTGGTAAAGTCATG
ATCGATAATTATCGGTGGTCCGGAGTGCCGTTTTACATCCGGACTGGGAAACGCTTAGCCGATAAGTTCACGCGAATCGA
CGTGGTGTTCAAACGGCCAGTCGTCAATATCTTCAATCATGAAGACGTCCGAGCTAATGACGACGCAGCAACCAGTCTCG
ATCCAAACATCTTGACAATCAACGTTGAACCGACTGAAGGCTTCGAGCTCCGCATGAATGCTAAAGCAATCGGCCAAGGC
TTCGCAACCACCCCGGTCAAGTTGAATTATTCTCACGATGCTGAAGCCACGGCTGGTAGCCCAGAAGCTTACGAACGTTT
GCTTCACGATGCCTTAAATGGCGACGCAACCAACTTTACCCACTGGCAAGAGGTTGCCGATTCGTGGAAATTCGTTGACG
TCATTCAAAAATACTGGGATGAACATCAACCCGAATTTCCAAACTACCGCCCTGGTACAATGGGACCAGATGCGGCCGAT
GAATTATTACGTCAAGATGGTCACCGCTGGGTCTACCGCAACTAG

Upstream 100 bases:

>100_bases
TCACCACGTATGGTTTAATATTAATACGGTAGTTTAATCTGAATTAATGCTTATGAACAAGTACTTGGTTTAAAATATTC
TTAGTAAAGAAGTGAAATTG

Downstream 100 bases:

>100_bases
CCGTCCTAACGTAGTCACTTAAATGGCTTAATTAAAAGAACCAGTTACCAACACTTGCCCAACAACGTGTTGATAACTGG
TCCTTTTTATATCGCTTTAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVISDSLADLNADQETVTQFASHF
YYQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMAPNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKE
LNDQLTATFNENQIYRIDHYLGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQN
HILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYRDEDKISSDSNTDTFVAGKVM
IDNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNHEDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQG
FATTPVKLNYSHDAEATAGSPEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAAD
ELLRQDGHRWVYRN

Sequences:

>Translated_494_residues
MSNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVISDSLADLNADQETVTQFASHF
YYQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMAPNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKE
LNDQLTATFNENQIYRIDHYLGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQN
HILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYRDEDKISSDSNTDTFVAGKVM
IDNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNHEDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQG
FATTPVKLNYSHDAEATAGSPEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAAD
ELLRQDGHRWVYRN
>Mature_493_residues
SNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVISDSLADLNADQETVTQFASHFY
YQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMAPNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKEL
NDQLTATFNENQIYRIDHYLGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQNH
ILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYRDEDKISSDSNTDTFVAGKVMI
DNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNHEDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQGF
ATTPVKLNYSHDAEATAGSPEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAADE
LLRQDGHRWVYRN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=497, Percent_Identity=32.3943661971831, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI108773793, Length=497, Percent_Identity=32.3943661971831, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI52145310, Length=357, Percent_Identity=30.5322128851541, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1788158, Length=495, Percent_Identity=37.7777777777778, Blast_Score=324, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17538218, Length=498, Percent_Identity=31.9277108433735, Blast_Score=287, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6324088, Length=498, Percent_Identity=36.3453815261044, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24643350, Length=491, Percent_Identity=35.6415478615071, Blast_Score=284, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24643352, Length=491, Percent_Identity=35.6415478615071, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=28.7784679089027, Blast_Score=212, Evalue=6e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56787; Mature: 56656

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVIS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHH
DSLADLNADQETVTQFASHFYYQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMA
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
PNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKELNDQLTATFNENQIYRIDHY
CHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCEEEEHHHH
LGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQN
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEHHHCCCCCEEEEECCCCHHHHHHHH
HILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYR
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHC
DEDKISSDSNTDTFVAGKVMIDNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNH
CHHHCCCCCCCCEEEEEEEEEECEEECCCCEEEECCHHHHHHHHHHHEEECCCHHHHCCC
EDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQGFATTPVKLNYSHDAEATAGS
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCEEEECCCCCCCCCCC
PEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAAD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ELLRQDGHRWVYRN
HHHHHCCCEECCCC
>Mature Secondary Structure 
SNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVIS
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHH
DSLADLNADQETVTQFASHFYYQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMA
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
PNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKELNDQLTATFNENQIYRIDHY
CHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCEEEEHHHH
LGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQN
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEHHHCCCCCEEEEECCCCHHHHHHHH
HILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYR
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHC
DEDKISSDSNTDTFVAGKVMIDNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNH
CHHHCCCCCCCCEEEEEEEEEECEEECCCCEEEECCHHHHHHHHHHHEEECCCHHHHCCC
EDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQGFATTPVKLNYSHDAEATAGS
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCEEEECCCCCCCCCCC
PEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAAD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ELLRQDGHRWVYRN
HHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]