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The map label for this gene is murR [H]

Identifier: 28379130

GI number: 28379130

Start: 2322894

End: 2323757

Strand: Direct

Name: murR [H]

Synonym: lp_2603

Alternate gene names: 28379130

Gene position: 2322894-2323757 (Clockwise)

Preceding gene: 28379127

Following gene: 28379133

Centisome position: 70.21

GC content: 40.16

Gene sequence:

>864_bases
ATGCAACTTATTGAACAATTAAGCCATCGTTCTGACTTTACCACTACCGAAACACGCATTGCAACTTATATTTTGAGTCA
CCAAGATGCAATGCCTAATATCTTAATTAAAGAATTGGCTGCTAAAACTTATACTTCGCATTCTGCCATAATTCGGTTAG
CGCAAAAGCTAGGGTTTCATGGGTTTCGTGATTTTCAGCGAGCACTAACAACTGAAATTGTCATTAACACCCAGGCCACA
ACAAACGTTGATGCTAACTTTCCATTCACTGATAAAGACGCAGTCACTGAAATCATCAAAAAAATGGCAGATCTAAAAAC
CAATGCCATTGCCAATGCTCAACATCAATTGAGACCTGAAGTGCTAACAAAGTCTGCTTATTTGCTAAACAAGGCACGAC
ATATTATGCTCTTTTCCCAAGGTGACTCTCAGCTACGGGCTCGCAGTTTTCAAAATAAGCTCGTTAAAATTAACCGATTT
GCCCAAATTGCCGAAATGTATGCAGATGAGGCCTGGAATATTGCCAGCCTGACACCACAAGATTGTGCCATGTTCATTTC
ATACGCTGGTAACACTGATGTTCATCAGCGATTTGCCAAATACTGTCAAGCACATCATATTCCTGTCATCGTCTTAACTG
GAAATGTCGATTCACCGCTACAACAATTCGCCACCTATCAATTAGTCATCACACAAAACGAACGGAATAACGCCAAACTA
GGAACGTTTGCCTCACAAGTCTCATTTGACTACGTCTTGGACACACTCTTTGCAATCATGTATGCAAATAACTTCCAAAC
AAACTTAGCCCACTTGAAAACAACTCAACTGTTGATTCAAGATGGGACACTACAGACAAAATAG

Upstream 100 bases:

>100_bases
CTGTGAAACCGGTACCAGGTCAATCAAACATCCCGGTGATTGTTAAGAATTTCGCACAATCCCATCATTTATCGTACAAT
GTTAATATTGGAGGGATTGT

Downstream 100 bases:

>100_bases
CGTGACGAATTGTGATTCTACAATTGAATAGCCGCTTTTAAAAAGGCCGCCTTCTTAATTTTATGAGAAGTCGGCCTTTT
CAATCACATTAATACGAATC

Product: transcription regulator

Products: NA

Alternate protein names: MurPQ operon repressor [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFHGFRDFQRALTTEIVINTQAT
TNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPEVLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRF
AQIAEMYADEAWNIASLTPQDCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKL
GTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK

Sequences:

>Translated_287_residues
MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFHGFRDFQRALTTEIVINTQAT
TNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPEVLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRF
AQIAEMYADEAWNIASLTPQDCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKL
GTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK
>Mature_287_residues
MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFHGFRDFQRALTTEIVINTQAT
TNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPEVLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRF
AQIAEMYADEAWNIASLTPQDCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKL
GTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK

Specific function: Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of murQ, is the specific inducer tha

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788767, Length=252, Percent_Identity=28.1746031746032, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082130, Length=268, Percent_Identity=25.3731343283582, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022821
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32492; Mature: 32492

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFH
CCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
GFRDFQRALTTEIVINTQATTNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPE
CHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCHH
VLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRFAQIAEMYADEAWNIASLTPQ
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKL
HHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCEEEEEEEECCCCCCCH
GTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure
MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFH
CCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
GFRDFQRALTTEIVINTQATTNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPE
CHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCHH
VLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRFAQIAEMYADEAWNIASLTPQ
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKL
HHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCEEEEEEEECCCCCCCH
GTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA