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The map label for this gene is nhaK [H]

Identifier: 28379133

GI number: 28379133

Start: 2326331

End: 2328334

Strand: Direct

Name: nhaK [H]

Synonym: lp_2608

Alternate gene names: 28379133

Gene position: 2326331-2328334 (Clockwise)

Preceding gene: 28379130

Following gene: 28379134

Centisome position: 70.32

GC content: 46.26

Gene sequence:

>2004_bases
TTGCAAACCGTTTTCTTAGTCTTATTACTCGTTGCGGCTGTCGTCGTTGCTAACGCCGTCTACGCACGTTTCAATCAAAT
TCCAGTCGCCTTTTTACAAATTGGGGCTGGGTTAATCTTGTCTCTGATTCCATTGTATCGAAATTTTGAATTGGAACCTG
AAATTTTCCTATTCGTCATTATTTCGATTTTAATGTTTAACGATGGCCAAAACACCAACATTCGCAAGCTCAGTCACCAG
TTTGGCACGACCCTTTCGCTTTCGGTAGTGTTAGCCATCGTGACCATCCTAATTGTTGGTACGGTCACTCACTTACTGAT
TCCCGAGTTTTCGCTGGCACTTGCTTTTGCCCTTGGCGCTATTATTACGCCAACCGATGCCGTCGCGGTCTCATCGATTA
CGACTAAAGTTGCGATTCCAGGTGAGGTCATGACGACCCTTGAAAATGAATCACTGTTCAATGACGCTTCCGGAATCGTG
GCCTTTAACTTAGCGATTGCTGCGATCGTCACTGGTAAGTTTTCGGTCTGGCACGGAGTCACTAACTTTTTATATGTTTT
TGCCGGTGGAATCTTCGTCGGCCTAATCATCGGTTATATCATTGTTGCTGTCAGGATCATGCTGATTCGCATGCGGGTCG
ATACACCTTCTGTGATCGTCCCCTACACATTACTGACACCGTTTGTCGTCTATTTCTTAGCTGAATCATTAGGCGTTTCC
GGTATCTTGGCTGTTGTTGCCACCGGTCTCATTCATGGTGTCCAGTCCGATCAATTACGGTTGACCACTTCCCGGCTACA
AATCGTGATGACAACGACTTGGTCAATCGTGGCTAGTATTTTGAACGGTATCGTCTTTGTGTTATTAGGTGTGTCGTTGC
CAAGTGTCATCAACCACTTACAGCAACGTGATACTAGTTCAGTCGCGGTATTAGTCGGTCTGGGAATCTTGCTCTACCTA
ATCATGACGTTCGCCCGTTTTCTCTGGACGCGCTTCGACTTAGCCCGTATTCGCGCGTGGGATAATCATGAAAAGACCCG
TAATGCATTCGTGATGGGTCTGAGCGGCGTTCACGGCACGATTACGCTGGCGATGGCCTTTTCATTACCACTAACACTCA
ACGGCAGTGCTTTTCCTTATCGCAACGATATTATTTTCGTTGCCGCAGTGGTCATTCTAACTAGTCTGATGGTGCCAACA
CTTTTGTTACCGTTGACGTTGCCAAAACAAGTTGTTAAGGTCACTGAAGATGAATTGGCAACCGCCAAAGCTGACATGGT
AACTCACGCTATTGATCTCATGCAAGCACGCCATGGTAATAATGCTGGCACTAGTAAAGTGATTGCGATTCTGTCCGGCC
AACGAGTACTAGATGGTCGTCCTAAGCGCTCGCAACTGGCGAGCTTGTTCGACGCCACTTTCAAAGTGGAACAAACCACT
ATTGATGAAATGGTTGCCAACAATGAAATCACGCCCCAGGCCGCTGAAAAGTACATGCGCGTCGCTAGTCAGACGCGTCT
GCAGAATCAACAAACTTTCTTCGAACGTTTGAAATTATTTTTCCGGTTTACACTCAGCAAATGGTCGCTCAGCAAAAAAG
CTCGTGCCCGACGTAAAATGTTCCGACAATACCGGCCCCATGGTGGTCAGAGTCGAGCTGAGCTCATGACTCGTAATCGG
CAAATGTGGCAACAAATGCGACAGATCGAACAAAAGCCGTATGAGGCCGTGTTAGCCTATTTAGCCGATACGATTACTGC
TGACAATCAGCAAGCTATCGGGATCGTTCGCCGCGCCTATGATGAACGTCATCGCCGCCTATCTGGTGAACGGGATTTCC
AGGAAACTCAAAATGAGCTTCTAATTGAAGCATTCCAGTTGGAATATAACTTCATTCAGACCCAATTAGCCAATAAAACA
TTCAGCTCAGAACTTGGTAACCAACTCTATGAACAAATTTCAACTGATCAGTTAGTTTACTTGCAATCGATCAATACCGA
CTAA

Upstream 100 bases:

>100_bases
CATTAGGTCCAGCCCCAAATTAATCATTGCAGATAATACTTTTATTCATATGATTGCGTTAAAATTAAACTACTTTACAA
AATCTAGGAGGAAATTTGGT

Downstream 100 bases:

>100_bases
ATTCGTTTAGTAATGTCAATAACGTGACCAACTGTCCACACCACTATTTGGGCATCGGGTCCGTTACACTAACGTTGTAC
CATTGGTCGAACTGCCAACT

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVIISILMFNDGQNTNIRKLSHQ
FGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGAIITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIV
AFNLAIAAIVTGKFSVWHGVTNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVS
GILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHLQQRDTSSVAVLVGLGILLYL
IMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGTITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPT
LLLPLTLPKQVVKVTEDELATAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTT
IDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKMFRQYRPHGGQSRAELMTRNR
QMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAYDERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKT
FSSELGNQLYEQISTDQLVYLQSINTD

Sequences:

>Translated_667_residues
MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVIISILMFNDGQNTNIRKLSHQ
FGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGAIITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIV
AFNLAIAAIVTGKFSVWHGVTNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVS
GILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHLQQRDTSSVAVLVGLGILLYL
IMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGTITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPT
LLLPLTLPKQVVKVTEDELATAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTT
IDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKMFRQYRPHGGQSRAELMTRNR
QMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAYDERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKT
FSSELGNQLYEQISTDQLVYLQSINTD
>Mature_667_residues
MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVIISILMFNDGQNTNIRKLSHQ
FGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGAIITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIV
AFNLAIAAIVTGKFSVWHGVTNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVS
GILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHLQQRDTSSVAVLVGLGILLYL
IMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGTITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPT
LLLPLTLPKQVVKVTEDELATAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTT
IDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKMFRQYRPHGGQSRAELMTRNR
QMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAYDERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKT
FSSELGNQLYEQISTDQLVYLQSINTD

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=399, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI15529998, Length=415, Percent_Identity=21.9277108433735, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI148727259, Length=384, Percent_Identity=20.5729166666667, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=541, Percent_Identity=31.2384473197782, Blast_Score=198, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147678, Length=356, Percent_Identity=23.5955056179775, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980847, Length=388, Percent_Identity=22.4226804123711, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=260, Percent_Identity=22.3076923076923, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=260, Percent_Identity=22.3076923076923, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360447, Length=365, Percent_Identity=24.9315068493151, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 74243; Mature: 74243

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVI
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ISILMFNDGQNTNIRKLSHQFGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGA
HHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIVAFNLAIAAIVTGKFSVWHGV
HCCCCHHHHHHHHHHEEECCHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
TNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCHH
GILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHL
HHHHHHHHHHHHCCCCCCEEEEHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQRDTSSVAVLVGLGILLYLIMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEECCCCHH
ITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPTLLLPLTLPKQVVKVTEDELA
HHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
IDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKM
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRQYRPHGGQSRAELMTRNRQMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKTFSSELGNQLYEQISTDQLVY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LQSINTD
EECCCCC
>Mature Secondary Structure
MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVI
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ISILMFNDGQNTNIRKLSHQFGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGA
HHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIVAFNLAIAAIVTGKFSVWHGV
HCCCCHHHHHHHHHHEEECCHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
TNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCHH
GILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHL
HHHHHHHHHHHHCCCCCCEEEEHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQRDTSSVAVLVGLGILLYLIMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEECCCCHH
ITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPTLLLPLTLPKQVVKVTEDELA
HHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
IDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKM
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRQYRPHGGQSRAELMTRNRQMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKTFSSELGNQLYEQISTDQLVY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LQSINTD
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA